Background: Due to the increase in the strains of antibiotic-resistant bacteria, it is necessary to obtain effective herbal compounds and nanocapsules synthesized from plant extracts to eliminate these strains. Objective: The present research study was conducted to examine the antibacterial effects of Cornus mass extract and its synthesized nano-capsules on the bacterial strains resistant to antibiotics. Methods: Samples including a combination of (urine, sputum, wounds and blood) of 436 hospitalized patients was collected and a number of 50 strains which demonstrated the highest resistance to antibiotics was separated to examine the antibacterial characteristics of the innovative compositions under study. Results: The findings showed that from among the 50 strains under study in 80% of the cases the E. coli bacteria and in 20% of the cases the Acinetobacter were the cause of infections. with the increase in the concentration of the extract, the size and dimension of nano-capsules increased so much so that in a concentration of 2.5 mg of extract, nano-particles as large as 72 nanometers was reported. Also, in fixed concentration of extracts diluted in more aceton, the size and dimension of nano-particles decreased to the extent that in a concentration using 15 mililitre of aceton, nano-particles equal to 66 nano meter was observed. Conclution: The findings relating to the antimicrobial characteristics of the Cornus mass extracts and its synthesized nano-capsules showed that respectively 36% and 56% of the strains under study possess antibacterial characteristics.