Showing 15 results for Akbari
M Azadbakht , J Akbari , S Pasandi ,
year 3, Issue 9 (2-2004)
Abstract
Parotia persica syn. Hamamelis persica (Hamamelidaceae) is indigenous in north province of Iran. Other species, Hamamelis virginiana, is grown in north of America and has a little distribution in the Europe. Plentiful investigation was performed on the Hamamelis virginiana and species but there is no study about Hamamelis persica and this study is the first report regarding the clinical and phytochemical study of the plant. Hamamelis persica leaves were collected in May, August and October of 1999 from Mazandaran. Extraction was accomplished from the leaves through percolation by ethanol 70. Tannins were measured by spectrophotometric method. For the clinical study as antiperspirant, a roll-on preparation was formulated on the extract by using of glycerol, propylene glycol, water, carbapol 934p, antioxidant and preservative. The dry extract was used in amount of 5% in the preparation. The formulation was prepared in suitable viscosity. The product stability was evaluated during 5 months. Then the product and placebo were given to volunteers. The clinical study was performed in a blind study by questionnaire. Results showed that the leaves contain mainly pyrogallol group tannins (6.11%). The product had suitable stability in clinical study. Sweating was reduced in 85 percent of the volunteers that used product as roll-on in armpit.
S Akbari ,
year 6, Issue 21 (Supplement 3 Anti-microbial plants 2007)
Abstract
Background: In recent years, systemic fungal infections due to Candida species have been received major consideration about inducing mortality in nosocomial patient's because of increasing in immunocompromised disorders such as AIDS and hematological disorders as well as long term use of broad spectrum antibiotics and corticosteroids.
Wide range use of antifungal agents specially azole compounds in treatment of sever Candidiasis has resulted in fungal resistance in Candida species, there fore, it is necessary to use antifungal susceptibility tests before selecting a suitable drug for such above mentioned infections which can resulted in the decrease in secondary drug resistance and better manipulation of treatment protocols.
Objective: The present study was done with the aim of evaluating antifungal effects of a aqueous and essential oils prepared from Thymus vulgaris and Origanum vulgare against fluconazole (FLZ) susceptible and Fluconazole resistance Candida albicans strains isolated from different types of Candida using standard drug susceptibility tests.
Methods: Evaluation of FLZ susceptibility of C. albicans strains by disk diffusion method showed 26 (78 %), 4 (12.1 %) and 3 (9.9 %) isolates were susceptible, dose – dependence and resistant, respectively.
Aqueous and essential oils from both Thymums vulgaris and Origanum vulgare showed inhibitory effects on growth of FLZ-susceptible C. albicans isolates, where as, only essential oils from Thymus vulgaris were found to be able to inhibit growth of FLZ-resistant C. albicans isolates.
Resultrs: These resultrs show that there is a direct relationship between FLZ resistance and resistance to both thymus and Origanum in C.albicans.
Thus, it is seems that these two plants could inbibit C. albicans growth by a similar mechanism which occure by FLZ.
Conclusion: In general, the results obtained in this study indicate that both thymus vulgaris and Origanim vulgare have potential values for growth inhibition of C. albicans in vitro.
M Shekofteh , F Akbari ,
year 8, Issue 29 (2-2009)
Abstract
Background: Pharmaceutical theses including medicinal plants subjects are invaluable informative sources. If they are disseminated properly, many research problems can be solved. Unfortunately, theses results are almost ignored. Content analysis is a bibliometrics technique that is applied in many subjects to help us know what the researchers have done before. Another way of information dissemination about the results of theses is through publishing in the scientific research journals. In this article, the medicinal plants theses conducted in the years between 1998 and 2006 have been analyzed and searched in the SID database to determine the number of theses that have been published as articles in scientific journals. Methods: The Technique used in this descriptive research is content analysis. This survey aims at specifying medicinal plants, according to their family, genus and species in the medicinal plants theses and their subject. Besides, the SID database was searched to determine the number of theses that their results have been published as journal articles. Results: The results indicated that medicinal plants theses comprised %20 of total theses. The family of "Labiatae" including 24 genus and 36 species and the genus "Tanacetum" including 13 species showed the great variation. Most of theses were about the specieses "danae racemosa" & "zataria multiflora". The Main subjects of dissertations were "phytochemistry", "pharmacological effects" and "essential oils". Only %7.4 of theses was published as articles in the scientific journals. Conclusion: publishing of the result of theses as scientific articles plays very significant role in pharmaceutical information dissemination. The Pharmacy faculties should be aware of the past researches to orient the students to choose the appropriate theses' subjects. Making data bases could be useful in this regard.
E Tekieh , Sh Rezazadeh , H Manaheji , A Akbari , J Zaringhalam,
year 9, Issue 34 (5-2010)
Abstract
Background: Inflammatory symptoms, hyperalgesia and edema, as a physiologic responses for stimulus can mediate via different mediators such as cytokines. Medicinal plants are an important source of substances which are claimed to induce anti-inflammatory effects. Objective: Regarding to these and on account of the Interlukine-6 roles in hyperalgesia and edema induction, the aim of this study explained to investigation of the pre-treatment effects of Achillea santolina and Stachys athorecalyx extracts on inflammation which induced by CFA in male Wistar rats. Methods: Methanolic and defatted extractions were done on aerial parts of the both plants: Achillea santolina and Stachys athorecalyx. 50, 100 and 200 mg/kg doses of extracts were selected for treatment. Results: Results indicated that pre-treatment with defatted and methanolic extracts of S. athorecalyx significantly decrease CFA-induced hyperalgesia and edema dose-dependently. At same situation only methanolic extract of A. santolina was effective in inflammatory signs reduction. Conclusion: It can concluded that A. santolina and S. athorecalyx extracts can be effective candidate for pre-treatment of inflammation, but the effective substances of them are different and need to be more investiged.
R Najafi Momen , M Torabi Goudarzi , A Bahonar, H Akbari , M Darabi ,
year 10, Issue 38 (5-2011)
Abstract
Background: Foot and Mouth Disease is a highly contagious viral disease that affects cloven - hoofed animals and has severe economic consequences. FMD causes painful sores and blisters on the feet, mouth and teats of animals. Objective: Clinical evaluation of Myrtle oil (Myrtus communis L.) caused by foot and mouth disease (FMD) in cattle. Methods: 76 cows and calves between one and five years of age and weight between 80 to 600 kg with clinical sing of FMD were selected randomly in two groups, receiving myrtle oil and control group. The data recorded during the three stages of clinical examination before treatment, second day and fourth day after treatment was performed. Results: Results indicated that recovery of mouth lesion with myrtle oil was remarkable as compared with control group. This difference was very statistically significant in two stages after treatment (p<0/001). Cases of oral lesions improved in the group treated with the oil in the second and fourth days, respectively, 80.9 and 93.6 percent and the rate control group were 20.6 and 58.6 percent, respectively. The result also indicated that amount of purulent-free secretion in myrtle oil group was 68.1 and 89.4 percent in the 2nd and fourth day respectively. The number was 48.3 and 62.1 percent for control group. Conclusion: The medication of myrtle oil on the wounds of FMD, causes mouth ulcers faster improvement and reduce discharge purulent.
E Torki , Mr Mokhber Dezfouli , A Hadjiakhoondi , Ar Vajhi , Ha Akbarin, Z Nazem Boukaei ,
year 10, Issue 39 (supplement 7 2011)
Abstract
Background: Reduced productivity due to cardiovascular disease in horses known as the third. Today, a number of drugs with different properties for the treatment of cardiovascular disease in horses which used when considering the need for newer drugs and their side effects are felt. Numerous studies on the effects of cardiovascular drugs and their effects have been carried out to examine the effects of echocardiography is used frequently. One of the most important medicinal plants is Crataegus oxycantha that has various properties such as antihypertensive, anti-arrhythmic and vasodilatory effects for it and other Crataegus species are considered.
Methods: In this study of 14 healthy head of race TARVBORD with age range from 9 to 15 years and weighing 340 kg up to 420 kg were used. Horses were divided in to two equal groups and treated. The amount of extract-treated group and control group, normal saline with the same volume of 2 mg/kg for 6 weeks, to bead ministered intravenously. The two-dimensional echocardiography to measure changes in lung arteries and the aorta was used.
Results: The size of PA, PAS and AO after injection treatment group than the control group showed significant increases in both groups were followed.
Conclusion: According to the results of research Crataegus oxycantha in horses has properties of vascular dilation and reduced their blood pressure, which can be in reducing cardiac after load, decreased blood pressure and swelling of lung tissue toxin used sheets.
Z Akbari , A Qaderi , S Kalate-Jari, A Mehrafarin , H Naghdi Badi,
year 11, Issue 42 (5-2012)
Abstract
Background: Trigonelline is known as a valuable metabolite of alkaloids group with the therapeutic affects, especially on diabetes. Objective: In this study the effect of 3 levels of nitrogen compounds (2x, full, and half) of basic MS media including KNO3 and NH4NO3 were evaluated on trigonelline production in suspension culture for normal and hairy roots. Methods: In order to hairy root induction, 2 strains of Agerobacterium rhizogenes (ATCC15834 and K599) via co-cultivation and injection methods were used. After appearing of hairy roots a molecular analysis by PCR and genes primers of rolB and virD was conducted to confirm insertion of T-DNA segments in root genome and that the roots were bacteria-free. Then, the hairy and normal roots for investigations of trigonelline production ability were cultured in suspension MS media and the treatments were arranged in an experimental based on Randomized Complete Block Design with 3 replications. After 28 days, the trigonelline contain of roots were analyzed by HPLC method. Results: The hairy roots were induced in the parts of plant such as crown, stem and leaf by the both strains of bacteria. The highest amount of trigonelline contain was achieved of the hairy roots cultured in MS2x media and the lowest was achieved in MS1/2N media. (13.98 and 8.74 mM/g dry mater respectively). Conclusion: the results indicate a main role of nitrogenous compounds (especially NH4+) and quick growth of hairy roots in enhancing of trigonelline production.
N Hosseini , M Akbari , R Ghafarzadegan , S Changizi Ashtiyani, R Shahmohammadi ,
year 11, Issue 43 (8-2012)
Abstract
Background: In recent years, plants natural products have gained considerable attention as natural preservers for use in different industries. Due to their free radical scavenging activities, phenolic compounds can prevent a wide range of diseases such as cancers and cardiovascular and neurodegenerative diseases. For a long time, different Ferulago species have been in use as medicinal plants worldwide.
Objective: The aim of this research was to investigate total phenolics and the antioxidant and antibacterial activities of essential oil and different extracts from F. angulata growing wild in Iran.
Methods: Antioxidant activity of our samples was examined by DPPH assay and their phenolic content was determined using the Folin – Ciocalteau method. Moreover, their inhibitory effects against five gram-negative and gram-positive bacteria including Shigella boidii, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Enterococcus faecalis were tested by using the disk diffusion method.
Results: Ethyl acetate fraction and methanol extract contained the highest levels of phenolic compounds (229.2 and 202.9 µg/mg galic acid) in this study. Also, essential oil of this plant exhibited low free radical scavenging activity (IC50= 36129.43µg/ml). On the other hand, ethyl acetate and aqueous fractions had the highest antioxidant activity (IC50 values of 20.153 and 28.28 µg/ml, respectively). Finally, studied samples had no significant antibacterial activities against tested organisms.
Conclusion: The essential oil of this plant can be used as a flavoring agent while extracts prepared from it have the potential to be used as natural antioxidants in relevant industries.
Mr Labbafi , I Allahdadi, Gha Akbari , F Najafi , H Khalaj , A Mehrafarin,
year 11, Issue 44 (11-2012)
Abstract
Background: Medical pumpkin is a medicinal plant that has a special place in the pharmaceutical industry, and evaluation of quantitative and qualitative yield is a under different agronomic treatments is necessary.
Objective: Investigating of quality/quantities yield of oil and morphological traits of Cucurbita pepo. affected of planting date and row arrangement.
Methods: This study was done as split plot on complete randomized blocks design with 3 replications at Research field of Aburaihan College, University of Tehran in 2010 and 2011 years. Treatments were included 3 main plots of planting dates (20 Apr, 21 May and 21 June) and 3 subplots of row arrangement (1, 1.5 and 2 meter between two rows). In this study evaluated 1000 seeds weight, seeds number in fruit, seeds weight per fruit, seed yield, seed produce index, oil percentage and oil yield.
Results: The year had not significant effect on any traits expect of oil percentage and seeds number in fruit. The interaction of planting date and row arrangement were significant in all quality and quantity traits. Maximum of seed yield, seed oil percent and oil yield were obtained in 1 meter row spacing21 may treatment and 1.5 meter21 June treatment. Maximum of unsaturated fatty acids percent and minimum of saturated fatty acids percent were obtained in planting date of June with 1.5 and 2 meter row spacing.
Conclusion: According to significant effect of row arrangement and planting date on seed and oil yield of medical pumpkin, quality and quantity growth followed economic yield of this plant could be improved by using appropriate agronomic management.
A Qaderi, Z Akbari, S Kalateh-Jari, F Fatehi, M Tolyat, M Jalali Moghadam, H Naghdi Badi,
year 15, Issue 59 (8-2016)
Abstract
Background: Trigonella foenum-graecum L. commonly known as fenugreek is a rich source of important medicinal metabolite, i.e. trigonelline.
Objective: In this study, hairy roots culture as a novel method for trigonelline production was evaluated.
Methods: For optimizing the hairy roots culture of Trigonella foenum-graecum, three strains of Agrobacterium rhyzogenes (ATCC15834, MSU440 and K599) via two inoculations methods including scotch and vacuum pump were used to agro-infiltration. Two elicitors including methyl jasmonate (0, 25, 50, 100 and 200 µM) and chitosan (0, 50, 100, 150 and 200mglˉ') were added to liquid medium as abiotic and biotic elicitors in various concentrations, respectively.
Results: The trigonelline content was increased via elicitation by methyl jasmonate and chitosan against control condition. The maximum trigonelline (36.7 and 37.3 mM/g D.W) were observed in 100 µM of methyl jasmonate and 150 mg/l of chitosan, respectively.
Conclusion: All parts of the seedling (crown, stem and leaf) were able to produce the hairy roots. Also, the highest dry weight of hairy root was obtained by A. rhizogenes strain 15834. The transformation of fenugreek using Agrobacterium rhizogenes to form hairy root cultures has the potential benefits of fast growth and rates of secondary metabolite production equal to or greater than that found for the intact plant.
Aa Akbarian, M Rahimmalek, Mr Sabzalian, Gha Saeidi,
year 16, Issue 62 (5-2017)
Abstract
Background: Bilehar or Kandal koohi (Dorema aucheri) which belongs to umbeliferae family is an endemic species of Iran. In respect to the extinction risk of this valuable species, until now no study has been performed to evaluate the effect of climate features on different traits in D. aucheri populations in different geographical areas.
Objectives: The goal of the study was to investigate phytochemical, morphological and antioxidant variation of Bilehar (Dorema aucheri) populations cultivated in different environmental conditions.
Methods: The experiment was conducted in a randomized complete block design in three replicates in November 2014 in three different areas. The total phenolics and flavonoid content were determined colorimetrically. The antioxidant activity of extracts were measured using two model systems, DPPH free radical scavenging (DPPH) and reducing iron (FTC). The essential oil was extracted based on hydro- distillation. To investigate the effect of environmental factors on phytochemical characteristics, Canonical Correlation Analysis (CCA) was applied.
Results: The results revealed the presense of significant differences between populations and various locations for the studied characteristics. Gorgue and Dishmook populations possessed the highest and the lowest amount of phenolics and essential oil in Margon and Isfahan provinces, respectively.
Conclusion: Finally, Gorgue possessed the best performance among all populations in respect to the phytochemical and morphological traits in all provinces, so, further studies are suggested to be done for the domestication of this plant population.
Mahdieh Sashourpour, Dina Morshedi, Saber Zahri, Farhang Ali Akbari, Marzieh Fottovat, Tayebeh Rajabian,
year 18, Issue 69 (3-2019)
Abstract
Many of neurodegenerative diseases (NDs) are associated with formation of the protein aggregates called amyloidal fibrils. Fibrillization of alpha-synuclein seems to be a key stage in the creation and progression of NDs and finding the compounds that inherent the toxicity of alpha-synuclein aggregates seems to be one of the most attention subjects in the neurodegenerative studies. In this study, the effects of various extracts derived from the roots of S. pinnatifida, on the alpha-synuclein cytotoxicity were assayed. In this regard, the process of fibrillization was induced in alpha-synuclein and then formation of aggregates was verified using standard methods such as thioflavin T fluorescence assay and microscopic fluorescence images. Neurotoxicity of alpha-syncline fibrils on PC12 cells was examined by MTT and LDH methods. Results showed that, after treatment with alpha-synuclein aggregates, the rate of cell death was evaluated significantly. In spite of the methanolic, hexane and ethyl acetate extracts, in the presence of dichloromethane and n.butanol extracts, the death of cells treated with alpha-synuclein were inhibited significantly. Furthermore, it was found that dichloromethane and n.butanol extracts contained high amount of anti-oxidant flavonoids. It can be concluded that the extracts of S. pinnatifida, significantly inhibit the harmful effects of toxic alpha-synuclein aggregates and can be used to treat amyloid-related disorders. However, it is required more investigations on the kind of the effective compounds of S. pinnatifida extracts.
L Naseri , M Akbari Bazm , M Khazaei ,
year 18, Issue 72 (11-2019)
Abstract
Tribulus terrestris is a one-year-old herb dispersed in hot and humid areas in the Mediterranean and warm regions of Europe, Asia, Africa and Australia. This plant has many benefits and is used in traditional medicine for the treatment of various diseases, including kidney stones, low blood pressure, anti-diabetic properties, and treatment of cardiovascular diseases, gastrointestinal disorders, and sexual performance in men and in treatment of hepatitis is recommended. The aim of this study was to investigate the pharmacological and therapeutic properties of pharynx in traditional medicine and scientific papers in modern medicine. This study is a systematic review based on the PRISMA checklist. Based on keywords, 440 titles were selected and after removing repetitive articles, 129 papers were extracted from various databases including PubMed, SID, ScienceDirect, Scopus and Magiran, and the Google Scholar search engine without time limit. T. terrestris has several properties, including antimicrobial, antibacterial, free radicals purification and inhibition of lipid peroxidation, and through various mechanisms of cell and molecules, it produces various pharmacological and therapeutic properties. One of the most important therapeutic properties of this plant is its anti-inflammatory and anti-cancer properties. Also, several clinical studies have shown that co-administration of tetanus extract with chemotherapy drugs reduces the side effects of drugs. Due to the lack of toxicity and side effects of T. terrestris, the use of herbs has been considered as a complementary drug in diet regimens for various diseases.
Gholam Ali Akbari, Seyedeh Akram Miri, Hossein Zeinali,
year 21, Issue 84 (12-2022)
Abstract
Background: Zingiber officinale (Zingiberaceae), is a tropical plant with knotted rhizomes. Objectives: The purpose of this research was to investigate the effect of using mineral and biological fertilizers based on algae on the quantitative and qualitative traits of the ginger plant and to choose the best cultivation medium. Methods: The experimental treatments included cultivation media in four levels and fertilizers in three levels. Hydrodistilled essential oil of the Z. officinale was analyzed by GC and GC-MS. Results: The largest amount of biological yield and yield per hectare was observed in the cultivation medium of vermicompost: perlite (70: 30) without fertilizers. The maximum harvest index with an average of 0.9 was estimated in the cultivation media of manure: soil (70: 30) combined with biofertilizer, vermicompost: perlite (70: 30) combined with biofertilizer, and manure: perlite (70: 30) combined with biofertilizer, respectively. The cultivation medium of animal manure: perlite (70: 30) combined with NPK chemical fertilizer produced the largest amount of essential oil. The highest proportion of geranial was observed in the cultivation medium of vermicompost: perlite (70: 30) combined with biofertilizer. The highest percentage of α-zingiberene was observed in the cultivation medium of vermicompost: perlite (70: 30) combined with NPK chemical fertilizer. The highest percentage of neral was obtained in the main treatments of animal manure: soil (70: 30) combined with biofertilizer. Conclusion: The use of chemical and biological fertilizers combined with organic cultivation media was fruitful and productive to meet the nutritional needs for the production of effective substances in ginger.
Ardeshir Qaderi, Shahmira Agahnia, Kamran Akbari Noghabi, Nasrin Qavami, Mohammad Reza Dehghani Meshkani, Hadi Kalantari, Javad Shaghaghi, Nassim Zarinpanjeh,
year 22, Issue 85 (3-2023)
Abstract
Background: The genus Mentha consists of several important medicinal plant species whose active ingredients are used for treating liver and prostate cancers, acute respiratory infection and allergic digestive problems, neuralgia, and migraines. Objective: This study aimed to investigate the effects of methyl jasmonate (MeJA) and salicylic acid (SA) in the field condition on the chemical composition of the essential oil of two in vitro propagated species of Mentha genus including Mentha x piperita and Mentha pulegium. Methods: M. piperita and M. pulegium species were propagated through the tissue culture method and the in vitro propagated plants were transferred to the farm after acclimatization. Then, the plants were treated with foliar application of MeJA and SA at four concentrations (0, 2, 4, and 6 mM) at three developmental stages. Chemical composition of the essential oils of samples were determined using a GC-MS analysis. Results: Both elicitors increased the level of menthol production in peppermint (M. x piperita), but in pennyroyal (M. pulegium), the level of pulegone production as the main secondary metabolite was decreased. Among different metabolites detected in the essential oil of peppermint, myrcene, octanal, γ-terpinene, ocimene, carvacrol, iso-menthol, neo-menthol, and oxygenated sesquiterpenes were the constituents with the lowest amounts under MeJA and SA treatment. Conclusion: The application of MeJA and SA significantly impacted on the quality and quantity of secondary metabolites of these species. The desired performance of valuable secondary metabolites can be achieved by determining the type and dosage of elicitors.
