Showing 11 results for نصیری
M Agajani Delavar , F Nasiri , Sh Hoseini ,
year 1, Issue 2 (5-2002)
Abstract
The objective of this study was evaluation of Vitex agnus castus) VACS) extract in alleviation of symptoms of premenstrual syndrome. The study was designed as double blind placebo controlled in two parallels groups (each 15 patients). Treatment phase lasted 3 consequent menstrual cycles (2 * 30 drops/ day =1.8 ml of VACS) or placebo. For assessment of the efficacy, visual analogue scale was used. Altogether 20 patients were included into the stastiscal analysis (each 10 patients). Good response of mental Symptoms to treatment was 70% for Vitex Compared to 30% for placebo. Seventy percent of women showed a great than 50% improvement in score compared with only 40% of taking placebo. Our results suggest a beneficial effect of Vitex in the treatment of PMS.
S Parvardeh , M Niapoor , M Nassiri Asl , H Hosseinzadeh,
year 1, Issue 4 (12-2002)
Abstract
As some Pistacia species showed anti-inflammatory activities, the antinociceptive, anti- inflammatory and acute toxicity effects of Pistacia vera L. hydroalcoholic gum extract were studied in mice and rats. Antinociceptive activity was determined using hot-plate, writhing, and formalin tests. The activity of the extract against acute inflammation was studied using xylene-induced ear edema in mice, The activity of the extract against chronic inflammation was assessed by the cotton pellet test in rats. LD50 value and the maximum non fatal dose of the gum were 3.77 and 1 g/kg (i.p.) in mice, respectively. The intraperitoneal injection of extract (0.25-2 g/kg) in mice showed significant and dose-dependent antinociceptive activity in hot plate. Naloxone (2 mg/kg, s.c.) pretreatment inhibited the antinociceptive activity of the extract. The extract (0.25 and 0.5 g/kg, i.p.) exhibited antinociceptive activity against acetic acid-induced writhing, which was not blocked by naloxone. The extract (0.25-1 g/kg, i.p.) also showed antinociceptive activities in formalin test. In the xylene ear edema, P. vera extract (0.25-1 g/kg, i.p.) showed significant anti-inflammatory activity in mice and exerted remarkable activity against chronic inflammation induced by the cotton pellet in rats as well. It is concluded that ethanolic extract of P. vera gum have antinociceptive effect and this may be mediated by opioid receptors, as well as inhibition of inflammatory mediators. The extract showed also anti-inflammatory effect against acute and chronic inflammation.
Asl M Nassiri, H Hosseinzadeh ,
year 2, Issue 5 (3-2003)
Abstract
The anticonvulsant, hypnotic and muscle relaxant effects of carbenoxolone were studied in mice. In pentylenetetrazole test ED50 values of diazepam and carbenoxolone were 1.13 mg/kg (95% CL: 0.89-1.44) and 283.3 mg/kg (95% CL: 144.27-556.29), respectively. In this test, carbenoxolone in doses of 200 and 300 mg/kg prolonged the onset time of seizure and decreased the duration of seizures. Carbenoxolone induced a protective activity against seizure in comparison with diazepam (0.1, 0.5 mg/kg), but not a complete protection against mortality. Anticonvulsant efficacy of carbenoxolone was similar as diazepam at a doses of 0-5 mg/kg. In maximal electroshock test, carbenoxolone in a dose of 400 mg/kg decreased the duration of seizure and produced protection against seizure but failed to protect against mortality in comparison with diazepam (0.25, 0.5, 3 mg/kg). In the potentiation of pentobarbitone sleep test, carbenoxolone signifiantly increased sleeping time and decreased latency dose dependently in of 100, 200, 300 mg/kg in mice. In traction test carbenoxolone (400 mg/kg) showed muscle relaxant activity (60%) and in accelerod performance carbenoxolone in doses of 300, 200 mg/kg showed a decline in motor function. It can be concluded that carbenoxolone posses anticonvulsant, muscle relaxant and hypnotic effects which may be have an efficacy in petitmal and grandmal seizures.
Hr Sadeghnia , M Nassiri Asl , Mh Haddadkhodaparast , H Hosseinzadeh ,
year 2, Issue 7 (9-2003)
Abstract
The previous pathological data has revealed that Salvia leriifolia root extracts have a neuroprotective activity against cerebral ischemia, thus the effect of the root extracts on lipid peroxidation was evaluated using experimental global ischemic-reperfusion in the hippocampus of rats. Cerebral ischemia was induced by four-vessel-occlusion (4VO) for 20 min. The aqueous and ethanolic extracts (0.1, 0.2 and 0.4 g/kg), phenytoin, as positive control, (50 mg/kg) and normal saline (10 ml/kg) were administered intraperitoneally 15 min after the induction of ischemia. The malondialdehyde (MDA) was measured by the thiobarbituric acid (TBA) test. The MDA level was higher in the saline group than the sham group. The MDA levels were recovered significantly upon phenytoin and the extracts therapy in the hippocampus of ischemic rats. These results suggest that S. leriifolia root extracts may show a protective effect against lipid peroxidation in cerebral ischemia.
S Parvardeh , M Nassiri-Asl , Mt Mansouri , H Hosseinzadeh ,
year 4, Issue 14 (5-2005)
Abstract
Background: Thymoquinone, the major constituent of Nigella sativa seeds, is a biologically active compound, which possesses several pharmacological effects. Objective: The aim of the present study was to evaluate the anticonvulsant effect of thymoquinone through intracerebroventricular (i.c.v.) injection. Method: The anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, were investigated using pentylenetetrazole (PTZ)-induced seizure model. Results: In PTZ-induced epileptic seizures, the i.c.v. injection of thymoquinone (200 and 400 mol) prolonged the onset and reduced the duration of tonic-clonic seizures. The protective effect of thymoquinone against lethality was 45% and 50% in the mentioned doses, respectively. In this study, flumazenil (1 nmol, i.c.v.) reversed the anticonvulsant activity of thymoquinone. Also, pretreatment with naloxone (10 mol, i.c.v.) antagonized the prolongation of tonic-clonic seizure latency, as well as reduction in seizure duration both induced by thymoquinone (200 mol, i.c.v.). Conclusion: These results indicate that thymoquinone may possess anticonvulsant activity probably through an opioid receptor-mediated increase in GABAergic tone.
M Nassiri Asl , H Hosseinzadeh ,
year 6, Issue 22 (5-2007)
Abstract
Background: Licorice (Glycyrrhiza sp.) belongs to family of Leguminosae. A number of components have been isolated from licorice, including triterpene saponins, flavonoids, isoflavonoides, chalcones and various other substances. Glycyrrhizic acid is the main biologically active component of it. Objective: The aim of this review is to provide an updated overview of experimental investigations focused on the antivirus effects of Glycyrrhiza and its active component, glycyrrhizin. Methods: A computerized search of published articles was performed using the electronic database such as MEDLINE from 1980 to 2005. Results: Glycyrrhiza exerts antiviral activity toward a number of viruses, including hepatitis A, B, C, varicella zoster, HIV, herpes simplex type-1, SARS, cytomegalo virus. Now glycyrrhizic acid has been used for the treatment of the patients with chronic active hepatitis and about the mechanism of glycyrrhizin’s activity against other viruses, it seems that glycyrrhizin inhibits replication, affects cellular signaling pathways, upregulate expression of inducible nitrous oxide synthase and production of nitrous oxide in macrophages. Conclusion: Thus, it seems that future clinical research is needed to define the possible use of licorice and it active component, glycyrrhizic acid as effective antivirus agents for treatment other viral infections.
Sh Shariati Rad , M Nassiri Asl , F Zamansoltani ,
year 6, Issue 23 (9-2007)
Abstract
Background: Passion flower has shown antianxeity and sedative effects in human. Objective: In this study, anticonvulsant effects of hydroalcoholic extract of passiflora were studied. Methods: Anticonvulsant effects of Pasipay were examined by using pentylenetetrazole model (PTZ) on mice. In this research pasipay, diazepam, and normal saline were injected i.p. at doses (0.05-0.4 mg/kg), (0.5-1 mg/kg), (10 ml/kg) respectively and after 30 minutes, PTZ (90 mg/kg, i.p) was injected to these mice. For investigating the mechanism of pasipay, flumazenil (2 mg/kg, i.p) and naloxone (5 mg/kg, i.p) were also injected 5 minutes before pasipay. Results: An ED50 value of pasipay was 0.2 mg/kg (%95 CL: 0.119, 0.408). In this model, pasipay at the dose of 0.4 mg/kg prolonged the onset time of seizure and decreased the duration of seizures compared to control (p<0.001). In this dose the seizure and mortality protection was 100%. Flumazenil and naloxone could suppress anticonvulsant effects of pasipay. Conclusion: It seems that pasipay may be useful for treatment of absence seizure and these effects may be related to the effect of it on GABAergic and opioid systems.
E Nasiri, Sj Hosseinimehr , M Azadbakht , Sa Madani ,
year 12, Issue 48 (12-2013)
Abstract
Background: A Burn injury is a major health problem in the developing countries. Various treatments were applied for treatment of burn wounds by Iranian traditional medicine for thousands of years ago. Objective: The purpose of this study was to evaluate the natural products based on treatment of burn wounds by herbalists or herbal medicine vendors in the Mazandaran province. Methods: This research was a cross-sectional study and all herbalists or herbal medicine vendors were enrolled in this study. Snow ball sampling method was used with a questionnaire. Demographic data, methods of treatment for wounds, itching and pain were collected. The results were analysised. Results: In this study, 29 herbal and 4 animal based products were recommended by herbal medicine vendors for treatment of burn wounds. The results showed that 77 percent of respondents to treatment of burn wounds by natural products were recommended. Aloe Vera gel was the first choice for treatment of burn that was recommended by the herbalists. Conclusion: These results are interesting to find new drugs for treatment of burn wound healing with regards to Iranian traditional medicine. Since there are limited animal and clinical studies for approval of these natural products, future studies are needed for assessment of these traditional medicines for treatment of burn injuries.
Sh Nozari, A Azadmehr, M Adine, F Javadi, H Jahanihashemi, M Nassiri-Asl, R Hajiaghaee, M Shahnazi, M Saraei,
year 15, Issue 58 (4-2016)
Abstract
Background: Production of anti-Toxoplasma drug with high efficacy and low side effect is one of the main priorities in toxoplasmosis researches. Herbal extracts has considered as a candidate for this purpose.
Objective: This study was performed in order to determine lethal effect of Artemisia absinthium L., Carum copticum L. and Gossypium hirsutum extracts on Toxoplasma gondii tachyzoites in vitro free cell line.
Methods: Tachyzoites of T. gondii RH strain were treated with concentrations of 10, 50, 100, and 200 mg/ml of Artemisia absinthium L., Carum copticum L., and Gossypium hirsutum extracts within 10, 30, and 45 min. Afterward, the tachyzoites were stained with alkaline methylene blue. Mortality rates of tachyzoites treated with extracts were determined. The results were analyzed with one way ANOVA and Post Hoc Test by SPSS software. P<0.05 was considered to be statistically significant.
Results: The overall, 100% of tachyzoites were killed at concentrations of 50, 100, and 200 mg/ml of Artemisia absinthium L. and 200 mg/ml of Carum copticum L. after 10, 30, and 45 min treatment. The lowest mortality rates at concentration of 10 mg/ml were 19.6±8.4, 4.30±2.26, and 4.63±2.1 for Artemisia absinthium L., Carum copticum L., and Gossypium hirsutum, respectively. The highest and lowest mortality rate of tachyzoites by Gossypium hirsutumin extract was
13.3 ±7.1. The mortality of tachyzoites were confirmed by bioassay in mice.
Conclusion: Anti-Toxoplasma activities of Artemisia absinthium L. and Carum copticum L. were significantly higher than Gossypium hirsutum. Further studies in order to clarify effectors are recommended.
Rasool Gharaee, Sima Zohari Anboohi, Nahid Saghi, Malihe Nasiri, Yasin Attarroshan, Mohsen Yaghubi,
year 19, Issue 74 (6-2020)
Abstract
Background: Patients with heart problems usually suffer from sleep disorders due to the course of the disease. One of the methods for treating sleep disorders is the use of aromatherapy. Objective: The aim of this study was to investigate and compare effects of aromatherapy with orange and Citrus aurantium extracts on sleep quality in patients with acute coronary syndrome admitted in the CCU. Methods: This clinical trial study was performed on 90 patients. The specimens were divided into three groups of aromatic herbal extracts with orange extract, Citrus aurantium extract and control group. The two groups underwent the treatment with these two extracts. In the control group only the usual care was taken. The data gathering tool was a SMHSQ questionnaire and a demographic profile form. Data were analyzed using SPSS software. Results: The mean sleep quality score in the two intervention groups was significantly lower than the control group (P= 0.0008). However, the mean score of sleep quality in the two groups of aromatherapy was not significant (P= 0.082). Conclusion: The aromatherapy of orange extract and Citrus aurantium improves sleep quality in patients. Each of the extracts can also affect the next dimension of the quality of sleep, which can be used as a topical scent.
Eshagh Khodadoost, Maryam Nakhaei, Ali Askari, Manizhe Nasirizade,
year 19, Issue 75 (9-2020)
Abstract
Background: Accuracy and lack of anxiety are two important factors in how nursing student’s work. Various methods, including aromatherapy, have been suggested to reduce anxiety and increase accuracy. Objective: The aim of this study was to investigate the effect of inhaling peppermint essential oilon anxiety and accuracy of nursing students in emergency department of Birjandeducational hospitals. Methods: This is a clinical trial study. One drop of peppermint essential oil (experimental group, n = 32) and one drop of sweet almond oil (placebo, n = 32) was poured on the gauze into the mask and inhaled for 20 minutes in 4 days. Both Bonardel Accuracy Questionnaire and Spielberger Anxiety Questionnaire were completed by both groups before and after the intervention. Data were analyzed using SPSS 22 software. The study used t-test, paired t-test, Kolmogorov-Smirnov test, and chi-square test. Results: The results of this study showed that both groups were similar in terms of demographic variables. Paired t-test showed no significant difference between the two groups before and after the intervention (P<0.05). Paired t-test results showed that the mean score of accuracy after the intervention was significantly higher in both groups (P<0.001). Conclusion: Peppermint essential oil compared to the placebo group was able to increase the accuracy of nursing students, which is consistent with the findings of other studies.
