Showing 16 results for عیدی
K Morteza-Semnani , M Azadbakht , M Saeedi , S Rohanifard ,
year 2, Issue 5 (3-2003)
Abstract
The genus Paederus has a world-wide distribution and comprises several hundred species and is most common during May through September in Iran. There appears to be no specific treatment for the Paederus dermatitis, thus we decided to evaluate herbal gel from chamomile and myrrh on Paederus dermatitis. Chamomile and myrrh have anti-inflammatory, anti-bacterial and anti-fungal activity in Iranian herbal medicine, thus we selected these plants for treatment of Paederus dermatitis. Ethanolic chamomile extract and the tincture of myrrh were prepared, then different gels containing chamomile (3.5%)-myrrh (1%) and myrrh (1% and 2%) were formulated and the best formulations were selected for preliminary clinical trial study in comparison with gel base. After proving the presence of active ingredients by TLC, HPLC and GC/Mass, the physical stability was evaluated in three tempretures (4, 25 and 40°C). Apigenin was 3.61 ± 0.62 mg/g of chamomile extract and 99.31% and 95.91% of papigenin was detected in gels containing chamomile (3.5%) and chamomile (3.5%)-myrrh (1%), respectively. The results of microbial control had corresponded to pharmacopoeia criteria. The results showed that the preparation containing 1% myrrh had the fewer side effects and the most effects on treatment of Paederus dermatitis.
S Oryan , M Eidi , E Yazdi , A Eidi , J Solati ,
year 2, Issue 6 (6-2003)
Abstract
Mulberry (Morus nigra L.) is non-toxic natural therapeutic agent shown to possess hypotensive and diuretic properties. The alcoholic extract of Morus nigra L. leaves was tested for hypoglycaemic effect in normal and streptozotocin-diabetic rats. Graded amounts (0.25, 0.5 and 1 g/kg) of alcoholic extract of Morus nigra leaves, when given to both normal and streptozotocin-diabetic rats orally, caused a significant reduction of serum glucose concentration in streptozotocin-diabetic rats but not normal rats was noticed. Also the alcoholic extract of mulberry did not change the level of insulin in normal and diabetic rats. These results suggest that the alcoholic extract of Morus nigra L. leaves given orally possess a hypoglycaemic effect in streptozotocin-diabetic rats.
A Eidi , M Eidi , Sh Oryan , F Fallahyan , R Darzi Darounkala ,
year 3, Issue 12 (11-2004)
Abstract
In traditional medicine leaves of olive (Olea europaea L.) are used as a diuretic, hypotensive, antibacterial and antiatherosclerotic. In the present study, oral administration of 0.1, 0.25 and 0.5g/kg body wt. of the alcoholic extract of leaves of olive for 14 days on the level of glucose and insulin in healthy and streptozotocin-induced diabetic rats were evaluated. The results showed that oral administration of the alcoholic extract of olive exhibited a significant reduction in blood glucose and increased plasma insulin in diabetic rats. The extract didnot change the level of blood glucose and plasma insulin in healthy rats significantly. A comparison was made between the action of the alcoholic extract and a known antidiabetic drug, glibenclamide (600 g/kg body wt.). The hypoglycaemic effect of the extract was greater than that observed with glibenclamide.
K Morteza-Semnani , M Saeedi , Z Nozadi ,
year 4, Issue 13 (2-2005)
Abstract
Background: Recently, many researchers have been involved in finding means to prevent or delay deterioration by oxidative reactions in cosmetic preparations. More recently, research has focused on developing safer and more effective antioxidants from natural sources. Objective: In this research the antioxidant activity of Green tea extract in comparison with commercial antioxidants in 2% hydroquinone cream were evaluated. Method: Green tea extract was tested for antioxidative activity in comparison with antioxidants (sodium metabisulfite and butilated hydroxy toluene BHT) at 0.1%, 0.5%, 1.0% and 2.0% w/w in 2% w/w hydroquinone cream. The systems were incubated in a dark room at 25°± 0.5°C and 45°± 0.5°C for three months. The physical stability and the percentages of hydroquinone remaining after two weeks and one, two, and three months were determined. Results: The experiment revealed that oxidation degradation of hydroquinone was accelerated by heat even with existence of antioxidants. In the third month at 25°± 0.5°C and 45°± 0.5°C, the extract demonstrated more antioxidant activity from other two commercial antioxidants at all concentrations, with about 43-53% and 32-44%, respectively, more hydroquinone remaining than in the control system (P<0.001). In the third month, the preparation containing 0.1%, 0.5%, 1.0% and 2.0% extract gave good physical formulation stability with about 70%, 75%, 77% and 81% hydroquinone remaining at 25°± 0.5°C, and 50%, 54%, 58% and 62% hydroquinone remaining at 45°±0.5°C, respectively. Conclusion: This suggested the possibility of using a Green tea extract as an effective natural antioxidant for substances that are oxidation-susceptible.
A Eidi , M Eidi , M Sokhteh ,
year 5, Issue 17 (Supplement 2 diabetes 2006)
Abstract
Background: Seeds of fenugreek (Trigonella foenum graecum L.), mostly used as a spice and condiment, are attributed with diuretic, carminative, antidiarrhoeal and antirheumatic effects in traditional medicine.
Objective: The purpose of this research was to experimentally assess the effect of alcoholic extracts fenugreek seeds on the level of ALT (alanine aminotransaminase) and AST (aspartate aminotransaminase) enzymes used in normal and streptozotocin-induced rats and to compare it with glibenclamide as a reference standard.
Method: In the present study, effects of 14 days oral administration of 0.1, 0.25 and 0.5g/kg body wt. of the alcoholic extract of fenugreek seeds on the level of ALT (alanine transaminase) and AST (aspartate transaminase) enzymes in healthy and streptozotocin-induced diabetic rats were evaluated. A comparison was made between the action of the alcoholic extract and a known antidiabetic drug, glibenclamide (600 μ g/kg body wt.).
Results: The results showed that orally administred alcoholic extract of fenugreek decreased serum ALT and AST only in diabetic but not in healthy rats.
Conclusion: Alcoholic fenugreek seed extract can serve as a good adjuvant in the present armamentarium of antidiabetic drugs. Further biochemical and pharmacological investigations should be carried out to elucidate in detail the mechanism of action of this plant.
M Eidi , F Soleimani , S Ebrahimi ,
year 6, Issue 24 (12-2007)
Abstract
Background: There is evidence about medicinal effects of Allium porrum, Liliaceae (leek) in Iranian traditional medicine. The plant has many properties such as improvement of digestive defects, atherosclerosis, joins pain, respiratory inflammation and kidney stone disease. The hypolipidemic effect of leek is investigated in diabetic rabbit, but its hypoglycaemic effect is unknown yet. Objective: In the present study the hypoglycemic effect of the ethanolic extract of Allium porrum L. (Leek) leaves was investigated in both normal and streptozotocin-induced diabetic mice. Methods: The animals were made diabetic using by streptozotocin (60 mg/kg, i.p.). The ethanolic extract at doses 100, 200, 250 and 300 mg / kg, i.p. were administered for 14 days intraperitoneally. Blood samples were obtained from heart after 14 days. The healthy and diabetic control groups were administered saline as vehicle of extract. Serum glucose and insulin levels were measured by glucose oxidase and radioimmunoassay methods, respectively. Results: The results showed that the ethanolic extract of leek significantly reduced the serum glucose in streptozotocin-induced diabetic mice but not in healthy mice. Also, the ethanolic extract increased serum insulin in diabetic mice. LD50 of ethanolic extract was measured 3500 mg/kg. Conclusion: The present data indicates that extract of leek has hypoglycaemic effect on diabetic animals by releasing insulin from pancreatic beta cells. So, this plant should be considered in future therapeutic researches.
F Katiraee , S Eidi , Ar Bahonar , H Zarrinfar , Ar Khosravi ,
year 7, Issue 27 (8-2008)
Abstract
Background: Candida albicans is the most important species, cause candida infections. The common forms of candidiasis are cutaneous and mucosal candidiasis, include oral (thrush), Vaginal candidiasis and onychomycosis. Different studies showed the drug resistance between candida albicans isolates, so it seems necessary to find replacement treatment for prevention of this resistance, side effects and avoidance of recurrent infection. Objective: Aim of this study is to determine of MICs of three essences against candida albicans isolates. Also, we compared the effects of essences between azole resistance and azole susceptible isolates. Method: In this study, 30 candida albicans isolates (16 azole resistance and 14 azole susceptible isolates) obtained from oral, vaginal and nails of patients with candidiasis were evaluated. In order to determine of susceptibility of Zataria multiflora, Geranium herbarum and Artemisia sieberi essences against candida albicans, Macrodilution broth Serial dilution of essences was prepared in sabouraud glucose broth tubes. Essences were solved in DMSO (0.12) as solvent. The same solvent at an appropriate concentration was used as a control (with and without organisms). After inoculation, incubation and subculture, MICs, compared to control tubes were determined. Results: The obtained results of MICs for Zataria multiflora, Geranium herbarum and Artemisia sieberi were between 0.11-0.25 µl/ml (mean: 0.18µl/ml), 0.4-1.25µl/ml (mean: 0.83µl/ml) and 0.62-1.25 µl/ml (mean: 1.4µl/ml), respectively. Also, there are not significant differences in MICs of these essences against azole resistance and azole susceptible isolates. Conclusion: We conclude that anti-candida activity of three herbal essences under study, against azole resistance and azole susceptible isolates were similar. With attention to resistance of different candida albicans to synthetic and chemical antifungals, these herbal essences are safe replacement treatments for cutaneous and mucosal candidia infections.
A Eidi, M Eidi , L Badiei,
year 7, Issue 28 (11-2008)
Abstract
Background: Pain is a sensory modality, which in many cases represents the only symptom for the diagnosis of several diseases. It often has a protective function. Although morphine has reigned for centuries as the king of painkillers, its rule hasn’t been totally benign. There are concerns about its addictive properties and side effects, which include respiratory depression, drowsiness, decreased gastrointestinal motility, nausea and several alterations of the endocrine and autonomic nervous systems. Since Salvia officinalis (sage) is used traditionally in the treatment of painful illnesses, it became worthwhile to evaluate its antinociceptive activities in mice. Objective: The objective of the present work is to evaluate the analgesic activity of essential oil of sage leaves by the formalin test in mice. Methods: The interaction between the plant leaves and opioidergic system on formalin-induced pain were carried out. The essential oil (0.2, 0.25 and 0.3 ml/kg) was injected intraperitoneally. The control groups were administered sunflower oil as vehicles of essential oil. Also, the LD50 of the essential oil of the plant was measured. Results: The results showed that the essential oil of the plant (0.3 ml/kg) decreased both phases of pain. Also, the antinociceptive effect of essential oil (0.3 ml/kg) and morphine (0.5 ml/kg body wt.) were reversed by pretreatment with naloxone (0.5 ml/kg). The LD50 of the essential oil was found 0.5 ml/kg, i.p. Conclusion: The potent analgesic effects were blocked by naloxone, indicating that the analgesic effects are associated with the activation of opioid receptors in the central nervous system. The present data indicate that the plant has analgesic effects on mice and the plant should be considered in future therapeutic researches.
M Eidi , M Bahar , A Eidi , O Pouyan , P Shahmohammadi ,
year 8, Issue 32 (12-2009)
Abstract
Background: Although several plants and procedures for treatment of kidney stone disease in Iranian folk medicine, Urolithiasis has been an important problem for patients, yet. Objective: Aim of present study, was the investigation of effect of Cucumis melo fruit skin hydro-alcoholic extract on calcium oxalate crystallization was studied in vitro. Methods: At first, hydro-alcoholic extract of plant at doses of 0.25, 0.5, 1, 2 and 4 mg/ml were prepared. Urine samples were collected from 6 individual men without kidney stone history. The urine samples were centrifuged. Calcium oxalate crystallization was induced by adding sodium oxalate to urine samples. Then, number and size of calcium oxalate crystals were measured by spectrophotometer and calibration of ocular lens of light microscope in control (without plant extract) and experimental (in presence of different of doses plant extract) groups, respectively. Results: Different doses of hydro-alcoholic extract of plant increased percent of small crystals (2.5-5 and 6-9 ), while decreased percent of big crystals (17-21, 22-30 and 31-40 in comparison to control samples. On the other hand, the plant increased mono-hydrate calcium oxalate crystals in comparison to di-hydrate calcium oxalate crystals. Also, the extract increased number of calcium oxalate crystals. Conclusion: Present results showed that hydro-alcoholic extract of Cucumis melo fruit skin could facilitate kidney stones excretion by decreasing size of crystals. So, it could prevent formation of kidney stone primary nucleus.
H Fallah Huseini, R Mohtashami , Sadeqi Z, Y Saidi , A Fallah Huseini ,
year 10, Issue 38 (5-2011)
Abstract
Background: The Nigella sativa L. seeds have been used as herbal medicine in several countries for the treatment and prevention of a wide range of diseases like cough and bronchial asthma, headache, nasal congestion, toothaches, intestinal worm, menstrual disorder, digestive abnormality, and impotence. Objective: The aim of this review was to collect updated available data focused on the pharmacological effects of Nigella sativa seeds. Methods: A computerized search was performed using the electronic database such as Medline and SID for selection and collection of articles focused on the pharmacological effects of Nigella sativa seed published from 1980 to 2010. Results: The large number of articles published on pharmacological effects of Nigella sativa seeds oil and extract over recent three decade. Results indicates that Nigella sativa seeds oil and seed extract with anti-inflammatory, anti - oxidant, antihistamine and immunomudulator properties has wide spectrum protective effects in various diseases such as cancer, hypertension, diabetes, hyperlipidemia, digestive and psychiatric disease observed in experimental and clinical studies. No side effects were reported in clinical study on therapeutic dosage of Nigella sativa seeds. Conclusion: The present scientific-based evidence indicates that Nigella sativa seeds have protective effects on liver, kidney and gastrointestinal, cardio vascular and nervous system, as well as beneficial effects on inflammatory, cancer, microbial and parasites diseases in experimental studies. Furthermore its efficacy on diseases such as diabetes hyperlipidemia and hypertension observed in experimental as well as clinical studies without any side effects. This information may be useful for scientist for induction of clinical trial for further investigation of efficacy and adverse effects of Nigella sativa seeds in treatment of hypertension, hyperlipidemia and diabetic disease.
Z Mahmoudi , M Soleimani, A Saidi, M Iranshahi , A Azizsoltanli ,
year 12, Issue 46 (5-2013)
Abstract
Background: Osteoporosis is one of the most prevalent deasese in current century. Estrogen deficiency is the basic cause of osteoporosis in menopaused women. Hormone Replacement Therapy (HRT) can increase the risk of breast and ovary cancers. Medicinal plant are natural source of secondary metabolite and can a reliable source for treating osteoporosis. Ferula gummosa (Galbanum) has been used in traditional medicine since ancient time. Objective: This study is focused on determining the effect of Galbanum root ethanolic extract on osteogenesis progress in Human Mesenchymal Stem Cells (hMSCs). Methods: The Bone Marrow hMSCs were seeded at 12 well plates and treated with different amount of Galbanum extracts (0.5 to 100µg/ml). Extract cytotoxicity were measured using MTT method .Effect of extract on osteogenesis was evaluated in time interval 7 and 14 days using_ Alkaline Phosphatase_ enzyme activity method. Results: The data analysis revealed a significant increase in cell proliferation in range of (0.5 to 5) µg/ml after 24, 48 and 72 hour of treatment with galbanum extract. Analysis of result revealed a significant increase in alkaline phosphatase (ALP) enzyme activity in the range of 1 to 10 µg/ml compared with control group. Conclusion: Ferula gumossa has been used in Iranian folk medicine for many years. Our in vitro study showed that Frula gummosa extract has osteoprotective effect.
R Ghafarzadegan , M Saeedi , A Malekhosseini , D Hekmatpou , R Ghafarzadegan , R Hajiaghaee ,
year 13, Issue 50 (5-2014)
Abstract
Background: Mental Health of Nurses in recent decades, attracted more attention. therefore strategies to reduce stress level is essential. Objective: Ginkgo biloba is one of thes herbs that has widely usage in complimentary medicine.With regard to the these points and consider of positive effects of Ginkgo biloba, this study aimed to assess the effect of Ginkgo biloba on nurses stress levels. Methods: This clinical trial was a double blined cross sectional study that nurses eligible to participate in the study using sampling methods were selected and Then randomly given drug or placebo to nurses. The medication and placebo was 40 mg, twice a day. After the two -week, the experimental and control group were switched. Result: In this study 62 nurses for two weeks consume ginkgo. Sum score of occupational stress questionnaire in case group after intervention was 40.15 with standard deviation 10.26. sum score of occupational stress questionnaire in control group after intervention was 34.55 with standard deviation 12. Conclusion: With regard that stress in nurses has problems such as decrease quality of care and unsatisfaction and unefficacy and fatigue and these factors lead to emotional disorder then intervention for control them is necessary. Therefore with regard that this research identify positive effect of ginkgo on stress levels and ginkgo is a part of complimentary therapy has a wildly application then we can use that for increase quality of life in nurses.
F Fathi , Sh Oryan , M Rafieian , A Eidi ,
year 14, Issue 54 (5-2015)
Abstract
Background: Recent studies have suggested that Mentha longifolia L. extracts (ME) have antioxidant activities. Objective: In this paper, attempts were made to determine the effect of MEin rat stroke model. Methods: Five groups (n=14) were studied the first and second groups (control and sham) received intraperitoneal injection with daily distilled water. The other three groups received 50, 100 and 200 mg/kg/day of the ME for 21 days. Two hours after the last dose, each main group was subdivided into middle cerebral artery occlusion (MCAO) operated for infarct volume assessment and intact subgroup for the assessment of brain and serum antioxidant activity and lipid proxidation of brain and serum, respectively. Results: Pretreatment with ME resulted in a significant reduction in total infarct volume. ME significantly increased antioxidant activity in penumbra and core in comparation with the control. The antioxidant activity of serum in the 100 mg/kg/day group was significantly higher than that of the control group. Malondialdeyde (MDA) level in the penumbra area was significantly elevated in the control group in comparison with other pretreated groups. ME at dose of 100 mg/kg significantly decreased MDA level in core area scale to the control. Moreover, ME with the doses of 100 and 200 mg/kg/day reduced MDA level of serum. Conclusion: ME may protect ischemia/reperfusion induced brain injury by increase in antioxidant activity, decrease in lipid proxidation and reduction in infarction volume.
Aa Akbarian, M Rahimmalek, Mr Sabzalian, Gha Saeidi,
year 16, Issue 62 (5-2017)
Abstract
Background: Bilehar or Kandal koohi (Dorema aucheri) which belongs to umbeliferae family is an endemic species of Iran. In respect to the extinction risk of this valuable species, until now no study has been performed to evaluate the effect of climate features on different traits in D. aucheri populations in different geographical areas.
Objectives: The goal of the study was to investigate phytochemical, morphological and antioxidant variation of Bilehar (Dorema aucheri) populations cultivated in different environmental conditions.
Methods: The experiment was conducted in a randomized complete block design in three replicates in November 2014 in three different areas. The total phenolics and flavonoid content were determined colorimetrically. The antioxidant activity of extracts were measured using two model systems, DPPH free radical scavenging (DPPH) and reducing iron (FTC). The essential oil was extracted based on hydro- distillation. To investigate the effect of environmental factors on phytochemical characteristics, Canonical Correlation Analysis (CCA) was applied.
Results: The results revealed the presense of significant differences between populations and various locations for the studied characteristics. Gorgue and Dishmook populations possessed the highest and the lowest amount of phenolics and essential oil in Margon and Isfahan provinces, respectively.
Conclusion: Finally, Gorgue possessed the best performance among all populations in respect to the phytochemical and morphological traits in all provinces, so, further studies are suggested to be done for the domestication of this plant population.
Maryam Saeidi, Fatemeh Zareie, Vahid Naseri Salahshoor, Rezvan Ghafarzadegan, Fereshteh Javaheri Tehrani ,
year 18, Issue 69 (3-2019)
Abstract
BACKGROUND AND OBJECTIVE: Foot Fissure is one of the most common diseases of the foot. This study was conducted to evaluate the effect of aloe vera gel and lanolin oil on the healing process of foot fissure in the Saveh city.
METHODS: In this interventional study that performed on 94 patients with foot fissure in both feet, the demographic information questionnaire, dry feet clinical assessment scale and the visual analogue scale (VAS) were used. The subjects in the first intervention group used the aloe vera gel, while the second intervention group used lanolin. The samples of the control group received placebo matched with the original medicine. Finally, the data were analyzed using statistical SPSS software, Ver. 23.
FINDINGS: The analysis of data's indicated no significant differences between the three groups before the intervention regarding the
feet dryness. But, two weeks after the intervention, the mean scores of dry feet in the intervention I group (Aloe Vera) was obtained significantly lower than in the intervention II group (lanolin) (P = 0.027). Also, the scores from visual analogue scale of the foot dryness showed no significant differences in the three groups before the intervention, while after the intervention, the mean visual analog score of the intervention I group was significantly (P = 0.007) lower than in the intervention II group.
CONCLUSION: The results of this study show a more favorable effect of aloe vera in comparison with lanolin in healing of dryness and foot cracking.
Fateme Yazdani, Iraj Rasooli, Fatemeh Sefidkon, Navid Saidi, Parviz Owlia,
year 19, Issue 73 (3-2020)
Abstract
Background: Klebsiella pneumoniae is one of the most important bacteria that cause nosocomial infections. This opportunistic pathogen has a high potential for antibiotic resistance and can generate a thick layer of biofilm. Nowadays, antibiotic resistant strains are emerging and widely spreading worldwide. Thus, it is necessary to combat drug-resistant strains through the use of novel drugs (such as medicinal plants). Objective: This study aimed to evaluate the in vitro antibacterial activity of Satureja rechingeri Jamzad, S. khuzestanica Jamzad, S. bachtiarica Bunge, and S. mutica Fisch. & C.A.Mey. essential oils against K. pneumonia ATCC 700603. Methods: For evaluation of the minimal inhibitory concentration (MIC) of essential oils, broth microdilution method was used. The microtiter plate assay method was used for the assessment of anti-biofilm activities of sub-MIC value of essential oils. Colorimetric and Iodometric assays were used for determination of urease and beta-lactamase activity. Results: According to data collected, the MIC value of essential oils was 4096 µg/mL. sub-MIC value of essential oils inhibited biofilm formation and urease activity of K. pneumoniae. However, S. khuzestanica had more activity. None of the essential oils caused a significant decrease in beta-lactamase activity of K. pneumoniae. Conclusion: Based on our analysis S. khuzestanica had a good antibacterial, anti-biofilm activities and urease inhibitory effects against K. pneumoniae, but additional studies are required to investigate the exact mechanisms of the antibacterial action and functions of this phytocompound.
