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Background: Acetaminophen as a common antipyretic drug, in overdoses, is poisonous for the liver.

Objective: The current study aimed to assess the protective effects of Ferula (F.) gummosa essential oils against the liver toxicity of acetaminophen in rats.

Methods: 80 male Wistar rats were randomly divided into 16 groups (n=5). Negative control group received only DMSO and the positive control group received acetaminophen 500 mg/kg b.w i.p. The treatment groups received F. gummosa essential oils (100 and 200 mg/kg b.w) i.p immediately after acetaminophen administration. The blood were collected for estimating the values of total antioxidant of plasma (FRAP) and liver enzymes; alanin teransferase (ALT), aspartate teransferase (AST), and alkaline phosphatase (ALP). Also, a piece of liver was used for determining of glutathione (GSH), lipid peroxidation (LP) concentrations, the activity of glutathione s-transferase (GST) and histopathological studies. 

Results: The data showed that F. gummosa essential oil modulate significantly the changes in the levels of GSH, GST and FRAP as well as the liver enzymes and lipid peroxidation compared to negative control group. Furthermore, the histopathological findings of the liver tissue was confirmed the biochemical results.

Conclusion: The essential oil extracted from F. gummosa possessed antioxidant activity which protects the liver against the toxic effects of acetaminophen.

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Background: Nowadays, liver disorders are one of the most serious and threatening problems of the health. Persian Golpar (Heracleum (H.) persicum) as an endemic medicinal plant with antioxidant and anti-inflammatory properties was  used (noted)  in the study for reducing the live injuries.

Objective: This experiment –for the first time- was conducted to consider the effects of the oils obtained from fruits of Persian Golpar on the liver toxicity induced by the injection of tetrachloride carbon (CCl4) in the Wistar rats.

Methods: In this study, 100 male Wistar rats were divided into 20 groups (n=5). Negative control group (NC) received DMSO and olive oil for two weeks and the positive control group (C) received DMSO as i.p injection in 14 days following CCl4 (2 ml/kg b.w) at day 15^th. The standard group (BHT), The treatment groups received H. persicum essential oils at both doses 100 and 200 mg/kg b.w as i.p injection following CCl4 (2 ml/kg b.w) at day 15^th. Then, the levels of the glutathione (GSH), total antioxidant capacity of plasma (FRAP), proxidasion lipids (MDA) and glutathione s-transferase (GST) and also liver enzymes for instance alanin teransferase (ALT) and aspartate teransferase (AST) were estimated at 4, 8, 16 and 24 h after CCL4 injection.

Results: The injection of the essential oils (at the both doses) obtained from Persian Golpar could surprisingly modulate the changes of the antioxidant/oxidative parameters as well as liver enzymes induced by CCL4 administration.

Conclusion: These results indicated the protective effect of Iranian Golpar essential oils on the liver. These effects are probably due to its antioxidant capacity.

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Background: Sepsis or infection is the second leading cause of death in people who are intensive care units. Due to the side effects of NSAIDs drugs, the use of medicinal plants with anti-inflammatory such as Rosa (R.) damascene Mill. for treating and reducing the symptoms of the inflammation has been suggested. Objective: The current study aimed to evaluate the anti-inflammatory and antioxodant activities of Rosa (R.) damascena Mill. essential oils in the lung tissue of the septic rats induced by the experimental cecal ligation and puncture (CLP) rat model. Methods: The rats were divided into 5 groups: negative control group, positive control group and treatment groups with R. damascena Mill. essential oils and indomethacin. After 24h of CLP surgery, the oxidative parameters were measured. Results: The induction of sepsis reduced the levels of glutathione (GSH), ferric reducing antioxidant power (FRAP) as well as increased the levels lipid peroxidation (LP), myeloperoxidase (MPO), prostaglandin E2 (PGE2) and cyclooxygenase-2 (COX-2), but it had no effects on glutathione S-transferase (GST). However, the treatments of rats with R. damascena Mill. essential oils have diminished the levels of biochemical parameters. Histopathological studies also demonstrated that the induction of sepsis resulted in the lung tissue damages, while these were improved by the treatment of rats with R. damascena Mill. essential oils. Conclusion: The oxidative damages of the lung tissue were induced by the sepsis and the administartionof R. damascena Mill. essential oils can be effecient in the prevention and improvement of the injuries.