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Alert for Consumption of Dorema aucheri: an Edible Medicinal Plant of Iran
M Eftekhari , F Oskou, Z Tofighi , E Motevaseli, S Jafari Nodooshan S , Mr Shams Ardekani ,
year 18, Issue 71 (9-2019)
Abstract
Background: Dorema aucheri (Apiaceae) grows in west and southwest of Iran. Young leaves of this plant are used orally as pickle or for cooking some local foods, as well as for the treatment of parasitic digestive infections and constipation.
Objective: The aim of present study was evaluation of cytotoxic potential and total phenols determination of D. aucheri young aerial parts extract and fractions and its pickle extract.
Method: The dried powders of D. aucheri young aerial parts and pickles were macerated with 80% methanol and fractionated with petroleum ether (PE), chloroform (CL), ethyl acetate (EA) and methanol (ME). Cytotoxic activity of the total extract, fractions and pickle extract on HT-29, MDA-MB-231, A549, Hela cancer and normal fibroblast cell lines were assessed by MTT assay. Total phenol contents of all samples were determined by Folin-Ciocalteu method.
Results: The potent cytotoxic activities were shown by PE and CL fractions on normal fibroblast cell line with IC50 equal to 17.66±2.3 and 48.80±1.24 µg/ml, respectively. Other fractions and extracts didn’t have considerable cytotoxic effects on other cell lines. In addition, two mentioen fractions had the lowest total phenols. ME and EA fractions with highest amounts of phenols showed the lowest cytotoxicity.
Conclusion: It is concluded D. aucheri compounds have potential to exhibit toxic effects on healthy cells. On the other hand, there is negative correlation between cytotoxicity and phenol contents of D. aucheri fractions.

Screening of Apiaceae fruits discovered natural resources with considerable biological potential
Zahra Tofighi, Mostafa Pirali Hamedani, Saeed Tavakoli, Mir Javad Tabatabaei, Marzieh Rabei, Shamim Mohtadi, Farnoosh Mirghaffari, Maryam Afshani, Farhad Kahrizi, Behruz Khodabandeloo, Saeede Jafari-Nodooshan, Mahdieh Shirzad, Elahe Motevaseli, Saied Goodarzi,
year 19, Issue 76 (11-2020)
Abstract
Background: Apiaceae fruits as common spices used for prevention of many chronic diseases including cancer. Objective: The present study compared the biological effects of different fruits from various Apiaceae tribes to compare and find the fraction source(s) with potential characteristics for further investigation including cancer prevention. Methods: Fruits of Apium graveolens L. (celery), Bunium persicum (Boiss.) B.Fedtsch. (black cumin), Petroselinum crispum (Mill.) Fuss (parsley), Pimpinella anisum L. (anise), Trachyspermum ammi (L.) Sprague (ajwain), Coriandrum sativum L. (coriander), Foeniculum vulgare Mill. (fennel), Anethum graveolens L. (dill), Heracleum persicum Desf. ex Fisch., C.A.Mey. & Avé-Lall. (Persian hogweed), Ferula assa-foetida L. (asafoetida), Cuminum cyminum L. (cumin) and Daucus carota L. (carrot) were extracted with 80 % methanol and fractionated by petroleum ether, chloroform, ethyl acetate and methanol, respectively. For different fractions and total extract of all 12 samples, cytotoxicity by brine shrimp test (BST) and MTT assay against cancer and normal cell (foreskin fibroblast cells), antioxidant effects by FRAP, and total phenols by Folin-Ciocalteu method were measured. Results: The general toxicity of ethyl acetate fractions (mean of data) was higher than others in the brine shrimp test (P < 0.05). The most cytotoxic fractions against colon carcinoma (HT-29), breast adenocarcinoma (MDA-MB-231) and alveolar basal epithelial adenocarcinoma (A549) cell lines were from Ammineae and Peucedaneae tribes while fruits fractions with high phenol contents and antioxidant powers were from Ammineae tribe. Conclusion: The Apiaceae fruits have significant biological effects, therefore the isolation of phytochemical compounds from active fractions with cytotoxicity is suggested in future studies.
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