year 1, Issue 4 (12-2002)                   J. Med. Plants 2002, 1(4): 35-40 | Back to browse issues page

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Shahverdi A, Bagheri M, Tavassoli F. A novel in vitro nitrofurantoin resistance breaker activity of Mentha longifolia L. essential oil. J. Med. Plants. 2002; 1 (4) :35-40
1- Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran , Shahverdiar
2- Laboratory of Pharmacognosy, Azarbaijan Medical Plant Research Center, Ardabil, Iran
3- General practitioners, Tehran, Iran
Abstract:   (4012 Views)
Bacterial resistance to antibiotics has emerged over the past decades as a major health problem. The challenge of antibiotic resistance has generally been met in two ways: through the discovery of completely novel antibiotics and by the use of derivatives of known antibiotics frequently prepared by semisynthetic methods to overcome existing resistance mechanisms. An alternative to these two pathways towards new therapies as a response to antimicrobial resistance is the development of inhibitors of resistance mechanisms. In this approach, the antibiotic is co-administered with an inhibitor that neutralizes the resistance mechanism and allows the antibiotic to affect microbial growth, even in resistant organisms. We have screened some plant extracts and essential oils for their nitrofurantoin breaker activity. In our investigation the ethanolic diluted essential oil of the aerial parts of Mentha longifolia were found to have nitrofurantoin resistance breaker activity against numerous nitrofurantoin resistances Entherobacteriaceae. To the best of our knowledge, the Present study is the first finding of antibacterial activity of nitrofurantoin against Enterobacteria resistant to it in the presence of essential oil of Mentha longifolia .
Full-Text [PDF 171 kb]   (1581 Downloads)    
Type of Study: Research | Subject: Pharmacognosy & Pharmaceutics
Received: 2014/12/14 | Accepted: 2014/12/14 | Published: 2014/12/14

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