year 2, Issue 5 (3-2003)                   J. Med. Plants 2003, 2(5): 13-22 | Back to browse issues page

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Nassiri A M, Hosseinzadeh H. Anticonvulsant, hypnotic and muscle relaxant effects of carbenoxolone, the synthetic constituent of licorice in mice. J. Med. Plants. 2003; 2 (5) :13-22
URL: http://jmp.ir/article-1-784-en.html
1- Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran , hosseinzadehh@yahoo.com
Abstract:   (4058 Views)
The anticonvulsant, hypnotic and muscle relaxant effects of carbenoxolone were studied in mice. In pentylenetetrazole test ED50 values of diazepam and carbenoxolone were 1.13 mg/kg (95% CL: 0.89-1.44) and 283.3 mg/kg (95% CL: 144.27-556.29), respectively. In this test, carbenoxolone in doses of 200 and 300 mg/kg prolonged the onset time of seizure and decreased the duration of seizures. Carbenoxolone induced a protective activity against seizure in comparison with diazepam (0.1, 0.5 mg/kg), but not a complete protection against mortality. Anticonvulsant efficacy of carbenoxolone was similar as diazepam at a doses of 0-5 mg/kg. In maximal electroshock test, carbenoxolone in a dose of 400 mg/kg decreased the duration of seizure and produced protection against seizure but failed to protect against mortality in comparison with diazepam (0.25, 0.5, 3 mg/kg). In the potentiation of pentobarbitone sleep test, carbenoxolone signifiantly increased sleeping time and decreased latency dose dependently in of 100, 200, 300 mg/kg in mice. In traction test carbenoxolone (400 mg/kg) showed muscle relaxant activity (60%) and in accelerod performance carbenoxolone in doses of 300, 200 mg/kg showed a decline in motor function. It can be concluded that carbenoxolone posses anticonvulsant, muscle relaxant and hypnotic effects which may be have an efficacy in petitmal and grandmal seizures.
Full-Text [PDF 248 kb]   (1196 Downloads)    
Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2014/12/14 | Accepted: 2014/12/14 | Published: 2014/12/14
* Corresponding Author Address: Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, P.O. Box: 1365-91775, Fax: (0511) 8437075, Mashhad, Iran

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