year 4, Issue 14 (5-2005)                   J. Med. Plants 2005, 4(14): 45-52 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Parvardeh S, Nassiri-Asl M, Mansouri M, Hosseinzadeh H. Study on the anticonvulsant activity of thymoquinone, the major constituent of Nigella sativa L. seeds, through intracerebroventricular injection. J. Med. Plants 2005; 4 (14) :45-52
1- Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- Department of Pharmacodynamy & Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, and Pharmaceutical Research Center, Bu-Ali Research Institute, Mashhad, Iran ,
Abstract:   (7142 Views)
Background: Thymoquinone, the major constituent of Nigella sativa seeds, is a biologically active compound, which possesses several pharmacological effects. Objective: The aim of the present study was to evaluate the anticonvulsant effect of thymoquinone through intracerebroventricular (i.c.v.) injection. Method: The anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, were investigated using pentylenetetrazole (PTZ)-induced seizure model. Results: In PTZ-induced epileptic seizures, the i.c.v. injection of thymoquinone (200 and 400 mol) prolonged the onset and reduced the duration of tonic-clonic seizures. The protective effect of thymoquinone against lethality was 45% and 50% in the mentioned doses, respectively. In this study, flumazenil (1 nmol, i.c.v.) reversed the anticonvulsant activity of thymoquinone. Also, pretreatment with naloxone (10 mol, i.c.v.) antagonized the prolongation of tonic-clonic seizure latency, as well as reduction in seizure duration both induced by thymoquinone (200 mol, i.c.v.). Conclusion: These results indicate that thymoquinone may possess anticonvulsant activity probably through an opioid receptor-mediated increase in GABAergic tone.
Full-Text [PDF 177 kb]   (2051 Downloads)    
Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2004/03/7 | Accepted: 2004/12/11 | Published: 2005/06/19

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Medicinal Plants

Designed & Developed by : Yektaweb