year 4, Issue 14 (5-2005)                   J. Med. Plants 2005, 4(14): 45-52 | Back to browse issues page

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Parvardeh S, Nassiri-Asl M, Mansouri M, Hosseinzadeh H. Study on the anticonvulsant activity of thymoquinone, the major constituent of Nigella sativa L. seeds, through intracerebroventricular injection. J. Med. Plants. 2005; 4 (14) :45-52
URL: http://jmp.ir/article-1-709-en.html
1- 2- Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- 1- Department of Pharmacodynamy & Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, and Pharmaceutical Research Center, Bu-Ali Research Institute, Mashhad, Iran , hosseinzadehh@yahoo.com
Abstract:   (5378 Views)
Background: Thymoquinone, the major constituent of Nigella sativa seeds, is a biologically active compound, which possesses several pharmacological effects. Objective: The aim of the present study was to evaluate the anticonvulsant effect of thymoquinone through intracerebroventricular (i.c.v.) injection. Method: The anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, were investigated using pentylenetetrazole (PTZ)-induced seizure model. Results: In PTZ-induced epileptic seizures, the i.c.v. injection of thymoquinone (200 and 400 mol) prolonged the onset and reduced the duration of tonic-clonic seizures. The protective effect of thymoquinone against lethality was 45% and 50% in the mentioned doses, respectively. In this study, flumazenil (1 nmol, i.c.v.) reversed the anticonvulsant activity of thymoquinone. Also, pretreatment with naloxone (10 mol, i.c.v.) antagonized the prolongation of tonic-clonic seizure latency, as well as reduction in seizure duration both induced by thymoquinone (200 mol, i.c.v.). Conclusion: These results indicate that thymoquinone may possess anticonvulsant activity probably through an opioid receptor-mediated increase in GABAergic tone.
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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2004/03/7 | Accepted: 2004/12/11 | Published: 2005/06/19

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