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:: Volume 3, Issue 15 (9-2005) ::
JMP 2005, 3(15): 33-42 Back to browse issues page
Effect of Hypericum perforatum L. for treatment of premenstrual syndrome
M Pakgohar * 1, M Ahmadi 2, MH Salehi surmaghi 3, A Mehran 4, Sh Akhondzadeh 5
1- (M.Sc.) 1- Faculty of Nurse Midwifery, Tehran University of Medical Science, Tehran, Iran , mpakgphar@razi.tums.ac.ir
2- (M.Sc.) 2- Labor & Delivery room Mahallat Hospital
3- (Pharm.D., Ph.D.) 3- Department of pharmacology, Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran
4- (M.Sc.) 1- Faculty of Nurse Midwifery, Tehran University of Medical Science, Tehran, Iran
5- (Ph.D.) 4- Psychiatric research center, Roozbeh Psychiatric Hospital, Tehran Univresity of Medical Science, Tehran, Iran
Abstract:   (2713 Views)
Introduction: The premenstrual syndrome is characterised by Physical and Psychological symptoms apearing regularly during the week prior to menstruation and disappearing within a few days of its onset, causing disruption to occuptional, family and personal functioning. Anecdotal evidence suggests that Hypericum is useful in releving the symtoms of premenstrual syndrome, but as yet there has been no clinical investingation of this. Objective: To compare the efficacy of Hypericum with placebo to treat the symptoms of premenstrual syndrome. Methods: A double blind, placebo controlled, randomised design was used in the clinical study. 70 Students of Tehran University with premenstrual syndrome who were in otherwise good Physical and mental health, completed Daily symptom Ratings for two cycles. Then participants devided were in two groups (active 35, Placebo 35) and took Hypericum or placebo for two complete menstrual cycles (2 30 drops for 7 days before menstruation). Results: Hypericum obtained a mean reduction of %46.45, in symptoms and placebo %18.1. There were significant reductions in all symptoms between two groups. (p=0.000) Treatment was well tolerated and there was not any discontinuation or complication with Hypericum. Conclusion: Hypericum treats premenstrual syndrome, and offers a therapy limited to the luteal phase for at least two cycles.
Keywords: Premenstrual syndrome, Hypericum perforatum, Medical plants
Full-Text [PDF 222 kb]   (822 Downloads)    
Type of Study: Research | Subject: Midwifery
Received: 2014/12/7 | Accepted: 2014/12/7 | Published: 2014/12/7
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Pakgohar M, Ahmadi M, Salehi surmaghi M, Mehran A, Akhondzadeh S. Effect of Hypericum perforatum L. for treatment of premenstrual syndrome. JMP. 2005; 3 (15) :33-42
URL: http://jmp.ir/article-1-696-en.html


Volume 3, Issue 15 (9-2005) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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