year 5, Issue 18 (5-2006)                   J. Med. Plants 2006, 5(18): 30-35 | Back to browse issues page

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Shiri N, Shafiei M, Pashaeirad S, Mahmoudian M. Study of noscapine effects on rat hind paw inflammation induced by bradykinin and histamine. J. Med. Plants. 2006; 5 (18) :30-35
URL: http://jmp.ir/article-1-669-en.html
1- Islamic Azad University North Tehran Branch
2- Department of Pharmacology, Razi Institute for Drug Research, Iran University for Medical Science, Tehran, Iran
3- Department of Biology, Shahid Beheshti University, Iran
4- Department of Pharmacology, Razi Institute for Drug Research, Iran University for Medical Science, Tehran, Iran , masmah99@iums.ac.ir
Abstract:   (6027 Views)
Background: Noscapine is an isoquline alkaloid from opium with antitussive effect. Our previous study indicated that noscapine is non-competitive inhibitor of bradykinin. Objective: Since bradykinin and histamine contribute in inflammatory processes, the effect of noscapine on rat hind paw inflammation induced by bradykinin and histamine was investigated. Method: Paw edema induced by subplantar injection of 0.1 ml bradykinin solution (3nmol/paw) or 1% histamine solution. Noscapin (1, 5 and 10 mg/kg) and indomethacin (10mg/kg) as standard anti-inflammatory drug were administered intraperitoneally (i.p) one hour before injection of bradykinin or histamine. The thickness of hind paw was measured with a caliper and compared to control groups before and 15, 30, 60, 90, 120 minutes after injection of bradykinin and before and 60, 120, 180 minutes after injection of histamine. Results: Administration of noscapine significantly suppressed the inflammation. The maximum anti-inflammatory effect of noscapin observed at dose of 5 mg/kg against bradykinin and at dose of 10mg/kg against histamine. So this activity of noscapine was similar to activity of indomethacin. Conclution: Our results showed that noscapine has anti-inflammatory effect on inflammatory response of rat hind paw. This effect, was comparable to the anti-inflammatory effect of indomethacin.
Full-Text [PDF 151 kb]   (1899 Downloads)    
Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2004/07/16 | Accepted: 2005/10/16 | Published: 2006/06/21

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