سال 8، شماره 29 و S5 - ( Supplement 5 (English) 1387 )                   سال 8 شماره 29 و S5 صفحات 30-38 | برگشت به فهرست نسخه ها

XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kianbakht S, Mozaffari K. Effects of Saffron and its Active Constituents, Crocin and Safranal, on Prevention of Indomethacin Induced Gastric Ulcers in Diabetic and Nondiabetic Rats. J. Med. Plants. 2009; 8 (29) :30-38
URL: http://jmp.ir/article-1-532-fa.html
Kianbakht S، Mozaffari K. Effects of Saffron and its Active Constituents, Crocin and Safranal, on Prevention of Indomethacin Induced Gastric Ulcers in Diabetic and Nondiabetic Rats. فصلنامه گياهان دارویی. 1387; 8 (29) :30-38

URL: http://jmp.ir/article-1-532-fa.html


1- Department of Pharmacology and Applied Medicine, Institute of Medicinal Plants, ACECR, Karaj ، skianbakht@yahoo.com
2- Department of Pathology, Faculty of Medicine, Iran University of Medical Sciences, Tehran
چکیده:   (5397 مشاهده)

Background: Saffron is the dried stigmata of the flowers of saffron (Crocus sativus L., Iridaceae). Saffron is well known for the treatment of gastric disorders in traditional medicine.

Objectives: In the search for new potential antiulcer agents, the effects of the ethanol extract of saffron and its active constituents crocin and safranal as compared with omeprazole against gastric ulcer induced by indomethacin in non-diabetic and streptozocin diabetic rats were studied.

Methods: The effects of pretreatment with saffron extract ( 25, 100 or 250 mg/kg, p.o.) , crocin ( 2.5, 5 or 10 mg/kg, p.o.) and safranal ( 0.25, 2, 5 ml/kg, p.o.) and omeprazole (30 mg/kg, p.o.) 30 min before administration of indomethacin (40 mg/kg, p.o. in non-diabetic rats and 15 mg/kg, p.o. in diabetic rats) on gastric lesions, increase of lipid peroxidation and decrease of glutathione levels induced by indomethacin in non-diabetic and diabetic rats were evaluated.

Results: Saffron extract, crocin, safranal and omeprazol prevented the gastric lesions, increase of lipid peroxidation and decrease of glutathione levels induced by indomethacin in non-diabetic and diabetic rats as compared with the control group (P < 0.01). The effects of saffron extract, crocin and safranal on the gastric ulcer index, lipid peroxidation and glutathione levels were comparable to omeprazole.

Conclusions: Saffron, crocin and safranal may prevent the gastric mucosa damage due to their antioxidant properties by increasing the gluthatione levels and diminishing the lipid peroxidation in the rat gastric mucosa.
واژه‌های کلیدی: Saffron، Crocin، Safranal، Gastric ulcers، Diabetes mellitus، Rat
متن کامل [PDF 156 kb]   (2199 دریافت)    
نوع مطالعه: پژوهشی | موضوع مقاله: فارماكولوژی و سم شناسی
دریافت: 1387/12/24 | پذیرش: 1388/3/30 | انتشار: 1388/3/31

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

ارسال پیام به نویسنده مسئول


بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به فصلنامه علمی پژوهشی گیاهان دارویی می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2021 CC BY-NC 4.0 | Journal of Medicinal Plants

Designed & Developed by : Yektaweb