Volume 2, Issue 34 (6-2010)                   J. Med. Plants 2010, 2(34): 165-176 | Back to browse issues page

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Tekieh E, Rezazadeh S, Manaheji H, Akbari A, Zaringhalam J. The Effects of Pretreatment with Achillea santolina and Stachys athorecalyx Extracts on CFA-induced acute inflammation in male rats. J. Med. Plants. 2010; 2 (34) :165-176
URL: http://jmp.ir/article-1-304-en.html
1- Department of Physiology, Neuroscience Research Centre, Shahid Beheshti University of Medical Sciences
2- Institute of Medicinal Plants, ACECR
3- Department of Physiology, Neuroscience Research Centre, Shahid Beheshti University of Medical Sciences , jzaringhalam@yahoo.com
Abstract:   (3776 Views)
Background: Inflammatory symptoms, hyperalgesia and edema, as a physiologic responses for stimulus can mediate via different mediators such as cytokines. Medicinal plants are an important source of substances which are claimed to induce anti-inflammatory effects. Objective: Regarding to these and on account of the Interlukine-6 roles in hyperalgesia and edema induction, the aim of this study explained to investigation of the pre-treatment effects of Achillea santolina and Stachys athorecalyx extracts on inflammation which induced by CFA in male Wistar rats. Methods: Methanolic and defatted extractions were done on aerial parts of the both plants: Achillea santolina and Stachys athorecalyx. 50, 100 and 200 mg/kg doses of extracts were selected for treatment. Results: Results indicated that pre-treatment with defatted and methanolic extracts of S. athorecalyx significantly decrease CFA-induced hyperalgesia and edema dose-dependently. At same situation only methanolic extract of A. santolina was effective in inflammatory signs reduction. Conclusion: It can concluded that A. santolina and S. athorecalyx extracts can be effective candidate for pre-treatment of inflammation, but the effective substances of them are different and need to be more investiged.
Full-Text [PDF 342 kb]   (1119 Downloads)    
Type of Study: Research |
Received: 2014/10/27 | Accepted: 2014/10/27 | Published: 2014/10/27

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