year 20, Issue 78 (5-2021)                   J. Med. Plants 2021, 20(78): 68-77 | Back to browse issues page

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Choopani R, Hajimehdipoor H, Molaei K, Kashafroodi H, Tavakolifar F, Ara L. Formulation and quality evaluation of Coriander Triphala tablet. J. Med. Plants 2021; 20 (78) :68-77
1- Traditional Medicine and Materia Medica Research Center and Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran ,
3- Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (9675 Views)
Background: Coriander Triphala is one of the famous drugs in traditional medicine which is consisted of Terminalia chebula, T. bellirica, Phyllanthus emblica, Coriandrum sativum, almond oil and honey. Traditional dosage forms should be converted to modern forms for better acceptance and suitable characteristics and stability. Objective: In the present investigation, the traditional form of Coriander Triphala was converted to film coated tablet and quality control of the tablet was performed. Methods: The fruits ofT. chebula, T. bellirica, Ph. emblica, C. sativum in equal proportions along with almond oil and honey in different proportions were used for tablet formulation with other excipients. Sixteen formulations were made and after pre-formulation studies, twelve of them were selected for making tablet. Prepared tablets went through primary quality control tests such as weight variation, friability, hardness and disintegration time. Finally, the best formulation was coated by green colored water soluble material and its physicochemical characteristics were determined. Results: Among different formulations, the tablet consisted of 98 mg of each species, 14 mg almond oil, 148 mg honey along with lactose, Avicel PH-102, croscarmellose sodium, PVP K30, magnesium stearate and silicone dioxide was the best one. Weight variation, hardness, disintegration time, total tannins content as pyrogallol were found 1192 mg ± 5 %, 20 kp, 25 min and 64.19 mg/tablet, respectively. Over 90 % of tannins were released after 60 min during dissolution test. Conclusion: The formulated tablet with suitable characteristics is a good substitution for traditional form and could be produced in industrial scale after complementary clinical trial studies.
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Type of Study: Research | Subject: Pharmacognosy & Pharmaceutics
Received: 2021/01/30 | Accepted: 2021/05/18 | Published: 2021/06/1

1. Peterson CT, Denniston K and Chopra D. Therapeutic uses of Triphala in Ayurvedic medicine. J. Altern. Complement. Med. 2017; 23(8): 607-614. [DOI:10.1089/acm.2017.0083]
2. Vibhushree Kumar TV, Manjunath K and Anantha Narayana DB. Dry granulation technique for converting Triphala churna as granules, tablets and organoleptic evaluation. Int. Res. J. Pharm. 2015; 6(6): 321-326. [DOI:10.7897/2230-8407.06669]
3. Momin M, Amin AF and Pundarikakshudu P. Development and evaluation of triphala formulations. Indian J. Pharm. Sci. 2004; 66(4): 427-432.
4. Aghili Khorasani MH. Qarabadin-e kabir. Ostad Allah Qoli Khan Qajarpublisher. Tehran. 1855.
5. Nazem Jahan MA. Qarabadin-e Azam. Iran University of Medical Sciences. Tehran. 2004.
6. Sadeghi F, Fazljou SMB, Sepehri B, Khodaie L and Monirifar H. Effects of Pistacia lentiscus and Coriander Triphala on adult gastroesophageal reflux disease: a randomized double-blinded clinical trial. Iran. Red Crescent Med. J. 2020; 22(6): e102260. [DOI:10.5812/ircmj.102260]
7. Frawley D and Lad V. The yoga of herbs: an ayurvedic guide to herbal medicines. Lotus Press. Santa Fe. 1986, pp. 174.
8. Varnick PK, Nambiar VPK and Ramakuthy C (Eds). Indian medicinal plants: a compendum of 500 species. Vol. 5. Orient Longman. Hyderabad.1996, pp. 263.
9. Prakash SS, Patra N, Santanu C, Kumar PH, Patro J and Devi V. Studies on Flowability, compressibility and In-vitro release of Terminalia chebula fruit powder tablets. Iran. J. Pharm. Res. 2011; 10(1): 3-11.
10. Chattopadhyay RR and Bhattacharyya SK. Terminalia chebula: an update. Pharmacogn. Rev. 2007; 1(1): 151-156.
11. Kumari S, Mythili Krishna J, Joshi AB, Gurav S, Bhandarkar AV, Agarwal A, Deepak M and Gururaj GM. A pharmacognostic, phytochemical and pharmacological review of Terminalia bellerica. J. Pharmacogn. Phytochem. 2017; 6(5): 368-376.
12. Deb A, Barua S and Das B. Pharmacological activities of Baheda (Terminalia bellerica): A review. J. Pharmacogn. Phytochem. 2016; 5(1): 194-197.
13. Variya BC, Bakrania AK and Patel SS. Emblica officinalis (Amla): A review for its phytochemistry, ethnomedicinal uses and medicinal potentials with respect to molecular mechanisms. Pharmacol. Res. 2016; 111: 180-200. [DOI:10.1016/j.phrs.2016.06.013]
14. Al-Snafi AE. A review on chemical constituents and pharmacological activities of Coriandrum sativum. IOSR J. Pharm. 2016; 6(7): 17-42. [DOI:10.9790/3013-067031742]
15. Aulton ME Ed. Pharmaceutics. The Science of dosage form design. Translated by Afrasiabi Garekani H, Tafaghodi M, Sajjadi SA and Sadeghi F. Mashhad University of Medical Sciences. Mashhad. 2005.
16. Rezghi M, Mortazavi SA, Fahimi Sh, Choopani R, Sheikholeslami MA and Hamzeloo-Moghadam M. Polyherbal tablet based on Iranian traditional medicine. J. Med. Plants. 2021; 20(77): 15-25.
17. Editorial Board. British Pharmacopoeia. The Stationary Office. London. 2015.
18. Hajimehdipoor H, Nikmanesh N and Mohammadi-Motamed S. Amla oil, a pharmaceutical product based on traditional knowledge for hair loss treatment. Res. J. Pharmacogn. 2019; 6(1): 57-61.
19. Moein E, Hajimehdipoor H, Toliyat T, Choopani R and Hamzeloo-Moghadam M. Formulation of an aloe-based product according to Iranian traditional medicine and development of its analysis method. DARU J. Pharm. Sci. 2017; 25(19): 1-9. [DOI:10.1186/s40199-017-0185-x]
20. Dehdari S, Hajimehdipoor H, Esmaeili S, Mortazavi SA and Choopani R. Formulation and finger printing of a poly herbal film-coated tablet for treatment of hemorrhoids. Res. J. Pharmacogn. 2020; 7(4): 39-47.
21. Editorial Board. United States Pharmacopeia 39, National Formulary 34. USP Convention. Rockville. 2016.
22. European Medicine Agency. ICH Q1A (R2). Stability testing of new drug substances and drug products. EMEA. London. 2003, 1-20.
23. Row RC, Sheskey PJ and Quinn ME. Handbook of pharmaceutical excipients. Pharmaceutical Press. London. 2009.
24. Savarikar SS, Barbhind MM, Halde UK and Kulkarni AP. Pharmaceutical and analytical evaluation of triphalaguggulkalpa tablets. J. Ayur. Integr. Med. 2011; 2(1): 21-25. [DOI:10.4103/0975-9476.78187]
25. Vaishali S, Deepika R, Anuj K and Himanshu C. Formulation and evaluation of herbal tablet containing Terminalia chebula extract. Lett. App. NanoBioSci. 2019; 8(4): 692-697. [DOI:10.33263/LIANBS84.692697]

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