سال 19، شماره 76 - ( English 1399 )                   سال 19 شماره 76 صفحات 1-20 | برگشت به فهرست نسخه ها


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Pournaghi N, Khalighi-Sigaroodi F, Safari E, Hajiaghaee R. A review of the genus Caesalpinia L.: emphasis on the cassane and norcassane compounds and cytotoxicity effects. J. Med. Plants. 2020; 19 (76) :1-20
URL: http://jmp.ir/article-1-2602-fa.html
پورنقی نرگس، خلیقی سیگارودی فرحناز، صفری الهه، حاجی آقایی رضا. مروری بر گیاهان جنس ابریشم مصری: با تاکید بر ترکیبات کاسان و نورکاسان و اثرات سمیت سلولی. فصلنامه گياهان دارویی. 1399; 19 (76) :1-20

URL: http://jmp.ir/article-1-2602-fa.html


1- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
2- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran ، khalighi@imp.ac.ir
3- Immunology Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
چکیده:   (854 مشاهده)
مقدمه: بسیاری از داروهای گیاهی در سیستم‌های پزشکی برای بهبود بیماری‌ها استفاده شده‌اند. یکی از این کاربردهای مهم، استفاده از آنها به عنوان عوامل سیتوتوکسیک برای درمان سرطان‌ها و تومورها است. مطالعات متعددی بر روی گونه‌های مختلف جنس ابریشم مصری شامل ارزیابی فعالیت‌های ضدمیکروبی، ضدتوموری، ضدالتهابی، ضدپسوریازیس، ضددیابت، آنتی‌اکسیدانی، ضدباکتری، تنظیم‌کننده سیستم ایمنی و کاهش قند خون انجام شده است. برخی گزارش‌ها نشان داده‌اند که این گیاهان حاوی مواد شیمیایی مختلف مانند پلیفنول‌ها، گلیکوزیدها، ترپنوئیدها، ساپونین‌ها و فالونوئیدها می‌باشند. هدف: هدف از این مطالعه، یافتن گونه‌هایی از جنس ابریشم مصری حاوی ترکیبات دی‌ترپنی با ساختار کاسان و نورکاسان با تأکید بر خواص سمیت سلولی بود. روش بررسی: در این مطالعه، کلمات کلیدی از جمله جنس Caesalpinia ، اثرات سیتوتوکسیک و ضد سرطان و ترکیبات cassane و norcassane در پایگاه داده‌های Scopus و Direct Science جستجو شدند. نتایج: سیزده ‌گونه ابریشم مصری از نظر ترکیبات فیتوشیمیایی و اثرات بیولوژیکی مورد بررسی قرار گرفت. قسمت‌های مختلف گیاهان از جمله برگ، دانه، ساقه، ریشه و غلاف میوه، حاوی ترکیبات دی‌ترپنی بودند. در میان این گونه‌ها، اثرات سمیت سلولی بر روی رده‌های مختلف سلول سرطانی بررسی شده و برخی از آنها دارای اثرات سیتوتوکسیک قابل توجهی بودند. نتیجه‌گیری: مطالعه حاضر نشان می‌دهد که جنس ابریشم مصری، دارای فعالیت سمیت سلولی ارزشمند است، اما برای بررسی اجزای فعال و توسعه احتمالی آنها به عنوان داروهای ضدسرطان جدید، مطالعات بیشتری لازم است.
متن کامل [PDF 626 kb]   (502 دریافت)    
نوع مطالعه: مروری | موضوع مقاله: فارماكولوژی و سم شناسی
دریافت: 1398/4/31 | پذیرش: 1398/8/18 | انتشار: 1399/9/11

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