year 16, Issue 62 (5-2017)                   J. Med. Plants 2017, 16(62): 158-168 | Back to browse issues page

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Hajizadeh A, Zare M, Rostamian S, Khanjani S. The protective effect of quercetin and it nanocrystal on anxiety-like behaviors induced by animal model of Alzheimer’s disease. J. Med. Plants 2017; 16 (62) :158-168
1- University of Mazandaran ,
2- Faculty of Herb, Amol University of Special Modern Technologies, Amol, Iran
3- Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran
4- Department of Physiology, Faculty of Biology Sciences, Shahid Beheshti University, Tehran, Iran
Abstract:   (1429 Views)

The protective effect of quercetin and it nanocrystal on anxiety-like behaviors induced by animal model of Alzheimer’s disease

Introduction: Alzheimer is a neurodegenerative disease which is characterized by progressive memory loss, diminished cognitive ability and behavioral disturbances such as anxiety-like behaviors. Quercetin is polyphenolic compound with antioxidant and neuroprotective effects.

Objective: Purpose of this study is evaluated antianxiety effect of quercetin and its nanocrystal in model of Alzheimer’s disease.

Methods: In present study, 49 male rats were divided into 7 groups: control (normal untreated rats), sham (received distilled water orally and saline intrcerebroventriculary), disease (received 10µg/rat STZ and distilled water) and disease treated with quercetin and its nanocrystal groups (received quercetin and its nanocrystal at doses of 10 and 25 mg/kg of body weight per day orally for four weeks after injection of STZ). Model of Alzheimer's disease induced by intracerebroventicular injection of STZ (icv-STZ) at doses of 10µg/rat. Elevated plus maze (EPM) test was used to assess anxiety-­like behaviors.

Results: Results indicated that icv-STZ injection significantly (P<0.001) decrease open arm times (%OAT) and open arm enters (%OAE) in the EPM test and in the groups treated with quercetin and its nanocrystal,these behavioral indexes significantly (P<0.001)  increased in the end of third and fourth weeks. Also in disease treated quercetin nanocrystal groups showed a significant decrease in anxiety-like behaviors compare with the disease treated quercetin groups.


The study demonstrates the effectiveness of quercetin and its nanocrystal in preventing the anxiogenic-like behaviors induced by Alzheimer’s model of rat. Also results show that treatment of alzheimer's rat with quercetin nanocrystal is more effective than quercetin.

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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2016/03/14 | Accepted: 2016/12/6 | Published: 2017/05/27

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