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:: Volume 1, Number 61 and S10 (supplement 10 2017) ::
Back to browse issues page JMP 2017, 1(61 and S10 ): 156-166
Effect of Kombucha Tea on Depression and Motor Activity in Mice
Abstract:   (827 Views)

Background: Depression is a threatening disease. Due to adverse effects of chemical antidepressant drugs, researcher’s attention has been shifted toward natural drug.

Objective: In this work, the antidepressant effect of Kombucha tea (KT) evaluated against reserpine induced depression in mice.

Methods: In this experimental study, 42 male mice were randomly divided into 6 groups of 7 mice. Vehicle mice received normal saline (1 mg/kg, i.p.), negative and positive control groups received reserpine (5mg/kg, i.p.) and fluoxetine (20 mg/kg, i.p.) respectively and treatment groups received Kombucha tea at doses of 250, 500, 1000 mg/kg, 18 h after administration of reserpine. Mice were then tested with forced swimming and rotarod tests. At the end of behavioral tests, blood sample were collected and used to assess blood antioxidant capacity.

Results: There was significant difference in the duration of immobility time between vehicle and reserpine treated groups (P<0.001). Administration of Kombucha tea at doses of 250, 500 and 1000 mg/kg into depressed mice significantly reduced the duration of immobility time. KT administration significantly improved blood antioxidant capacity of mice blood.

Conclusion: These results provide support for the potential antidepressant effects of Kombucha tea against.

Keywords: Kombucha tea, Depression, Forced swimming test
Full-Text [PDF 301 kb]   (1170 Downloads)    
Type of Study: Research | Subject: Medicinal Plants
Received: 2017/02/13 | Accepted: 2017/02/13 | Published: 2017/02/13
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Effect of Kombucha Tea on Depression and Motor Activity in Mice. JMP. 2017; 1 (61) :156-166
URL: http://jmp.ir/article-1-1617-en.html
Back to browse issues page Volume 1, Number 61 and S10 (supplement 10 2017)
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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