سال 9، شماره 35 - ( English 1389 )
سال 9 شماره 35 صفحات 105-99 |
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Khosrokhavar R, Ahmadiani A, Shamsa F. Antihistaminic and Anticholinergic Activity of Methanolic Extract of Barberry Fruit (Berberis vulgaris) in the Guinea- Pig Ileum. J. Med. Plants 2010; 9 (35) :99-105
URL: http://jmp.ir/article-1-272-fa.html
URL: http://jmp.ir/article-1-272-fa.html
Khosrokhavar R، Ahmadiani A، Shamsa F. Antihistaminic and Anticholinergic Activity of Methanolic Extract of Barberry Fruit (Berberis vulgaris) in the Guinea- Pig Ileum. فصلنامه گياهان دارویی. 1389; 9 (35) :99-105
R Khosrokhavar* 
1، A Ahmadiani2 ، F Shamsa3
1، A Ahmadiani2 ، F Shamsa3
1- Food and Drug Laboratory Research Center and Food and Drug Control Laboratories, MOH& ME ، khosrokhavar_r@yahoo.com
2- Department of Pharmacology, Faculty of Medicine, the Medical Sciences University of Shaheed Beheshti
3- Department of Chemistry, Faculty of Pharmacy, the Medical Sciences University of Tehran
2- Department of Pharmacology, Faculty of Medicine, the Medical Sciences University of Shaheed Beheshti
3- Department of Chemistry, Faculty of Pharmacy, the Medical Sciences University of Tehran
چکیده: (4857 مشاهده)
Background: Barberry (Berberris vulgaris) is a well known medicinal plant in Iran and has also been used as food. Objective: This study was conducted to evaluate antihistaminic and anticholinergic activity of methanolic extract of barberry fruit. Methods: Methanolic extract was prepared and pharmacologically studied on isolated guinea- pig ileum, dose- response curves of histamine and acetylcholine with and without methanolic extract were plotted. Results: The pA2 values for antihistaminic activity of methanolic extract and dexchlorpheniramine were calculated (extract pA2± S.E.M = 3.53 ± 0.16 [-logC(g/l)] dexchlorpheniramine pA2 ± S.E.M.= 9.36 ± 0.14 ([-logC (M)]) and compared with each other. The pA2 values of anticholinergic activity of methanolic extract and atropine were also calculated (extract pA2± S.E.M = 4.18 ± 0.17 [-logC(g/)] atropine, PA2 +S.E.M = 8.99 ± 0.13 [-logC(M)]) and compared. Conclusion: The results indicated antihistaminic and anticholinergic activity of methanolic extract.
نوع مطالعه: پژوهشی |
موضوع مقاله:
فارماكولوژی و سم شناسی
دریافت: 1389/4/1 | پذیرش: 1389/6/9 | انتشار: 1389/8/7
دریافت: 1389/4/1 | پذیرش: 1389/6/9 | انتشار: 1389/8/7
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