سال 19، شماره 74 - ( 4-1399 )                   سال 19 شماره 74 صفحات 1-24 | برگشت به فهرست نسخه ها


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Amiri S, Fotovat R, Panahi B, Tarinezhad A, Mohammadi S A. Review of abiotic and biotic elicitors’ roles in secondary metabolites biosynthesis of periwinkle (Catharanthus roseus (Linn.) G. Don). J. Med. Plants. 2020; 19 (74) :1-24
URL: http://jmp.ir/article-1-2416-fa.html
امیری صالح، فتوت رضا، پناهی بهمن، تاری نژاد علیرضا، محمدی سید ابوالقاسم. مروری بر نقش محرک‌های زیستی و غیر‌زیستی در افزایش بیوسنتز متابولیت‌های ثانویه گیاه پروانش (Catharanthus roseus (Linn.) G. Don). فصلنامه گياهان دارویی. 1399; 19 (74) :1-24

URL: http://jmp.ir/article-1-2416-fa.html


1- گروه زراعت و اصلاح نباتات، دانشکده کشاورزی، دانشگاه زنجان،‌ زنجان،‌ ایران
2- پژوهشکده بیوتکنولوژی کشاورزی شمال‎غرب و غرب کشور، پژوهشگاه بیوتکنولوژی کشاورزی ایران، سازمان تحقیقات، آموزش و ترویج کشاورزی، تبریز، ایران ، b.panahi@abrii.ac.ir
3- گروه زراعت و اصلاح نباتات، دانشکده کشاورزی، دانشگاه شهید مدنی آذربایجان، تبریز، ایران
4- دانشکده کشاورزی، گروه به‌نژادی و بیوتکنولوژی گیاهی، دانشگاه تبریز، تبریز، ایران
چکیده:   (682 مشاهده)
مقدمه: بر اساس آخرین بررسی‌های آماری و اپیدمیولوژیک در ایران، سرطان بعد از بیماری‌های قلبی عروقی و حوادث، سومین عامل مرگ و میر به شمار می‌آید. دو آلکالوئید وین‌بلاستین و وین‌کریستین که عمدتاً در بخش هوایی گیاه پروانش تولید می‌شوند، به صورت وسیعی در درمان تومورهای انسانی مورد استفاده قرار می‌گیرند. استفاده از روش‌های زیست‌فناوری برای افزایش تولید این آلکالوئید‌ها یک امر ضروری به شمار می‌رود. با توجه به تنظیم‌پذیر بودن مسیر بیوسنتز آلکالوئیدهای ایندول ترپنوئیدی (TIAs)‌، تغییر در غلظت پیش‌ماده‌ها و آنزیم‌ها توسط محرک‌های زیستی و غیر‌زیستی می‌تواند رویکرد مهم در این زمینه باشد. این محرک‌ها از طریق القاء سیستم ایمنی گیاه پروانش باعث تحریک بیوسنتز و انباشت متابولیت‌های وین‌بلاستین و وین‌کریستین می‌شوند. هدف: در این مطالعه استفاده از محرک‌های زیستی و غیر‌زیستی بر روی مسیر بیوسنتز آلکالوئیدهای ایندول ترپنوئیدی جهت بهبود تولید این متابولیت‌ها مورد بحث و بررسی قرار می‌گیرد. روش بررسی: در این مطالعه با استفاده از کلید واژه‌های مناسب در موتورهای جستجوگر، مقالات مناسب انتخاب شد. نتایج: بررسی مطالعات انجام شده نشان داد که محرک‌های زیستی و غیرزیستی ابزار مؤثری در افزایش تولید متابولیت های با ارزش در گیاه پروانش می‌باشد. نتیجه‌گیری: بر اساس مطالعات ما این مقاله اولین مقاله در زمینه مرور اثرات تحریک‌کننده‌ها بر تولید وین‌بلاستین و وین‌کریستین می‌باشد و می‌تواند در روشن کردن مسیر آینده تحقیقات در این زمینه مفید باشد.
متن کامل [PDF 957 kb]   (337 دریافت)    
نوع مطالعه: مروری | موضوع مقاله: كشاورزی و اتنوبوتانی
دریافت: 1397/10/16 | پذیرش: 1398/5/22 | انتشار: 1399/4/31

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