year 1, Issue 4 (12-2002)                   J. Med. Plants 2002, 1(4): 27-34 | Back to browse issues page

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1- Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- Pharmaceutical Research Center, BuAli Research Institute, Mashhad, Iran
3- Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran , hosseinzadehh@yahoo.com
Abstract:   (3960 Views)
As the antioxidant effects of some species of Pistacia have been reported, the antiheptotoxicity effect of the hydroethanolic extract of P. vera gum was studied in rats. Hepatic injury was induced in rats using carbon tetrachloride (CCl4). The pretreatment of rats with P. vera gum extracts (0.5 and 1 g/kg, i.p.) reduced SGPT value in CCl4 treated animals but had no effect on SGOT level. LD50 value and the maximum non fatal dose of the gum were 3.77 and 1 g/kg (i.p.) in mice, respectively. The extract comprised flavonoids, saponins and hydrotannins. It is suggested that the ethanolic extract of P. vera gum has a protective activity against liver damage induced by CCl4 in rats.
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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2001/06/10 | Accepted: 2002/08/18 | Published: 2002/12/20