year 16, Issue 61 And S10 (supplement 10 2017)                   J. Med. Plants 2017, 16(61 And S10 ): 47-59 | Back to browse issues page

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Abstract:   (4989 Views)

Background: In the world of today, where the diseases are on the rampage, doctors and patients both are trying to diagnose and treat them, however, the difficulty is ignoring some causes in diagnosis and even treatments. Paclitaxel is a treatment chemical drug that can cause kidney toxicity, including degenerative changes in the renal parenchyma.

Objectives: The aim of this study was investigated the effects of green tea as a strong antioxidant on kidney tissue and blood factors of kidney functions in mice treated with paclitaxel.

Methods: Doing this experimental 35mice divided into7groups randomly: 1control group was not achieved any materials,2control group achieved Saline for one week,1Shame group were injected with Paclitaxel IP of 0.3 mg/kg for three days; 2&3Shamegroupinjected with IP of green tea with doses of 200mg/kg and 300mg/kg respectively for twenty-eight days.1&2 Experimental group went through treatment with green tea extract and paclitaxel, they first achievedsaiddoses of green tea for twenty-eight daysand then paclitaxel with the dosage of 0.3 mg/kg from the the fourteenth day for three days. Seven days after the last injection, the kidneywas dissected and after fixation in Formaline buffer solve, have been painted with haematoxylin and eozine, and was studied. Also the level of blood urea and creatininehas been investigated. Data was analyzed by ANOVA test.

Results: Blood urea and creatinine levels in 1Shame group were significantly increased compared with the control group the after using green tea extract in 1&2 Experimental group showed a significant decrease(P<0.05). In 1Shame group, dilatation of the renal collecting tubular with minor tissue necrosis was observedthe trend in 1 & 2 Experimental group to be reversible so that the control group had no significant difference.

Conclusion: On the Base of these results, consuming green tea was decreased of the level of blood factors of kidney and the kidney tissue changes brought about by paclitaxel will be improved.

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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2015/02/3 | Accepted: 2016/01/18 | Published: 2017/02/13