سال 24، شماره 93 - ( 2-1404 )
سال 24 شماره 93 صفحات 101-79 |
برگشت به فهرست نسخه ها
Ethics code: FBMS/EC/AE/1983.
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Chukwu O O, Iyare C O, Okorocha A E, Konyefom N G, Emelike C U, Onyeji G N, et al . Moringa oleifera Lam. is a potential mitigator of neurodevelopmental defects caused by prenatal stress in Wistar rats. J. Med. Plants 2025; 24 (93) :79-101
URL: http://jmp.ir/article-1-3709-fa.html
URL: http://jmp.ir/article-1-3709-fa.html
Moringa oleifera Lam. is a potential mitigator of neurodevelopmental defects caused by prenatal stress in Wistar rats. فصلنامه گياهان دارویی. 1404; 24 (93) :79-101
چکیده: (1435 مشاهده)
Background: Gestational stress is a key factor in neurodevelopmental impairments in offspring, affecting learning, memory, and emotional regulation. Moringa oleifera Lam. leaf extract (MoLE) with its anti-inflammatory and antioxidant properties, may offer neuroprotective benefits. Objective: This study evaluated impact of MoLE on the neurodevelopment of Wistar rat pups subjected to Chronic Unpredictable Stress (CUS). Methods: Twenty-five healthy virgin female Albino-Wistar rats were randomly assigned to five groups of five rats each, which underwent a two-week CUS protocol. Groups were as follows: Group I (received ad libitum water and standard rat chow), Group II (received MoLE at 5 mg/kg body weight/day), Group III (received MoLE at 10 mg/kg body weight/day), Group IV (CUS + MoLE at dosage of 5 mg/kg body weight/day), and Group V (CUS + MoLE at dosage of 10 mg/kg body weight/day). Offspring were evaluated for histological changes in the hippocampus, prefrontal cortex, and amygdala, while serum malondialdehyde (MDA) levels, and behavioral tests were carried out to assess anxiety-like behaviors and spatial memory. Results: Histological analysis revealed MoLE supplementation mitigated cellular damage. MDA levels were elevated among pups exposed to MoLE-supplemented and CUS, but not in MoLE-supplemented groups. Behavioral results for anxiety-like behavior were inconclusive. Spatial memory results showed a non-significant decrease in all groups, requiring further investigation. Conclusion: This study provides preliminary evidence for M. oleifera's potential neuroprotective effects against gestational stress-induced damage. Further research with more specific behavioral tests is needed to confirm its effects on anxiety-like behavior and spatial memory.
نوع مطالعه: پژوهشی |
موضوع مقاله:
گياهان دارویی
دریافت: 1403/5/8 | پذیرش: 1403/12/27 | انتشار: 1404/2/24
دریافت: 1403/5/8 | پذیرش: 1403/12/27 | انتشار: 1404/2/24
| بازنشر اطلاعات | |
 |
این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است. |
