سال 8، شماره 31 - ( English 1388 )                   سال 8 شماره 31 صفحات 74-64 | برگشت به فهرست نسخه ها

XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Haghparast A, Zarringhalam J, Khatibi A, Dianati E, Shams J. The Fruit Essential oil of Cuminum cyminum L. Reduced the Acquisition but not Expression of Ineffective dose of Morphine-Induced Conditioned Place Preference in Morphine- Sensitized Mice. J. Med. Plants. 2009; 8 (31) :64-74
URL: http://jmp.ir/article-1-332-fa.html
Haghparast A، Zarringhalam J، Khatibi A، Dianati E، Shams J. The Fruit Essential oil of Cuminum cyminum L. Reduced the Acquisition but not Expression of Ineffective dose of Morphine-Induced Conditioned Place Preference in Morphine- Sensitized Mice. فصلنامه گياهان دارویی. 1388; 8 (31) :74-64

URL: http://jmp.ir/article-1-332-fa.html


1- Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran ، Haghparast@yahoo.com
2- Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran
چکیده:   (3346 مشاهده)
Background: Cuminum cyminum fruit essential oil (FEO) dose-dependently can attenuate the expression of morphine tolerance and dependence in morphine-dependent mice. Objective: In this study, the effects of Cuminum cyminum FEO on acquisition and expression of morphine-induced conditioned place preference (CPP) in morphine-sensitized mice were studied. Methods: Repeated subcutaneous (s.c.) administration of morphine (5 mg/kg), once daily for three and 5 days free of the opioid (sensitization period), increased conditioning response induced by ineffective doses of morphine (0.25, 0.5 and 0.75 mg/kg). Results: The results showed that intra-peritoneal (i.p.) injection of Cumin FEO (0.001, 0.01, 0.1, 0.5, 1 and 2% 5 ml/kg) or Tween-80 (0.5% 5 ml/kg), 60 min before administration of morphine or saline during sensitization period (acquisition), decreased the conditioning response induced by ineffective dose of morphine (0.5 mg/kg s.c.) at the doses of 1% (P<0.05) and 2% (P<0.001) while Cumin FEO (0.001-2% i.p.), just 60 min before the test on post-conditioning phase (expression experiments), did not alter the conditioning scores in morphine- and non-sensitized mice. Conclusion: Our findings showed that the Cuminum cyminum fruit essential oil reduces the acquisition but not expression of morphine-induced conditioned place preference in morphine-sensitized mice.
واژه‌های کلیدی: <، i>، Cuminum cyminum<، /i>، Morphine، Conditioned place preference، Sensitization، Mice
متن کامل [PDF 256 kb]   (1579 دریافت)    
نوع مطالعه: پژوهشی | موضوع مقاله: فارماكولوژی و سم شناسی
دریافت: 1388/3/3 | پذیرش: 1388/4/22 | انتشار: 1388/6/31

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

ارسال پیام به نویسنده مسئول


بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به فصلنامه علمی پژوهشی گیاهان دارویی می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2022 CC BY-NC 4.0 | Journal of Medicinal Plants

Designed & Developed by : Yektaweb