سال 18، شماره 71 - ( English 1398 )                   سال 18 شماره 71 صفحات 84-77 | برگشت به فهرست نسخه ها

XML English Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Eftekhari M, Oskou F, Tofighi Z, Motevaseli E, Jafari Nodooshan S S, Shams Ardekani M. Alert for Consumption of Dorema aucheri: an Edible Medicinal Plant of Iran. J. Med. Plants 2019; 18 (71) :77-84
URL: http://jmp.ir/article-1-2667-fa.html
Eftekhari M، Oskou F، Tofighi Z، Motevaseli E، Jafari Nodooshan S S، Shams Ardekani MR. Alert for Consumption of Dorema aucheri: an Edible Medicinal Plant of Iran. فصلنامه گياهان دارویی. 1398; 18 (71) :77-84

URL: http://jmp.ir/article-1-2667-fa.html

1- School of Pharmacy, International Campus, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, 14174-14411, Tehran, Iran
3- Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran ، e_motevaseli@tums.ac.ir
4- Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده:   (3806 مشاهده)
Background: Dorema aucheri (Apiaceae) grows in west and southwest of Iran. Young leaves of this plant are used orally as pickle or for cooking some local foods, as well as for the treatment of parasitic digestive infections and constipation.
Objective: The aim of present study was evaluation of cytotoxic potential and total phenols determination of D. aucheri young aerial parts extract and fractions and its pickle extract.
Method: The dried powders of D. aucheri young aerial parts and pickles were macerated with 80% methanol and fractionated with petroleum ether (PE), chloroform (CL), ethyl acetate (EA) and methanol (ME). Cytotoxic activity of the total extract, fractions and pickle extract on HT-29, MDA-MB-231, A549, Hela cancer and normal fibroblast cell lines were assessed by MTT assay. Total phenol contents of all samples were determined by Folin-Ciocalteu method.
Results: The potent cytotoxic activities were shown by PE and CL fractions on normal fibroblast cell line with IC50 equal to 17.66±2.3 and 48.80±1.24 µg/ml, respectively. Other fractions and extracts didn’t have considerable cytotoxic effects on other cell lines. In addition, two mentioen fractions had the lowest total phenols. ME and EA fractions with highest amounts of phenols showed the lowest cytotoxicity.
Conclusion: It is concluded D. aucheri compounds have potential to exhibit toxic effects on healthy cells. On the other hand, there is negative correlation between cytotoxicity and phenol contents of D. aucheri fractions.
واژه‌های کلیدی: Bilhar، Cytotoxic، MTT assay، Phenolics، Umbelliferae
متن کامل [PDF 479 kb]   (929 دریافت)    
نوع مطالعه: پژوهشی | موضوع مقاله: فارماكوگنوزی و فارماسيوتيكس
دریافت: 1397/6/18 | پذیرش: 1397/12/1 | انتشار: 1398/6/2

فهرست منابع
1. Mozaffarian V. A dictionary of Iranian plant names. Farhang Moaser. Iran. 1996.
2. Izadi J and Ejlali R. Germination improvement in seeds of gum ammoniac (Dorema ammoniacum). Iran J. Range Des. Res. 2009; 15: 455-63.
3. Khorasani A. Makhzan ol-Advieh. Publication and education of Islamic revolution. Iran. 1992, pp: 472-3.
4. Jorjani S. Zakhire ye Khawrazmshahi. The academy of Medical Sciences of Iran. Iran. 2003, pp: 36-90.
5. Tonekaboni H. Tohfat ol momenin. Nashr-e Shahr. Iran. 2007, pp: 283 - 4.
6. Mosaddegh M, Esmaeili S, Naghibi F, Hamzeloo Moghadam M, Haeri A, Pirani A and Moazzeni H. Ethnomedical survey and cytotoxic activity of medicinal plant extracts used in Kohgiluyeh and Boyerahmad Province in Iran. J. Herbs Spices Med. Plants 2012; 18: 211-21. [DOI:10.1080/10496475.2012.671801]
7. Rajaei P and Mohamadi N. Ethnobotanical study of medicinal plants of Hezar mountain allocated in south east of Iran. Iran. J. Pharm. Res. 2012; 11: 1153 - 67.
8. Tavana A, Pourrajab F, Hekmatimoghaddam SH, Khalilzadeh SH and Lotfi MH. The hypoglycemic effect of Dorema aucheri (Bilhar) extract in diabetic type 2 patients: A first clinical trial. Int. J. Pharm. Clin. Res. 2015; 7: 343-7.
9. Ahangarpour A, Teymuri Zamaneh H, Jabari A, Nia HM and Heidari H. Antidiabetic and hypolipidemic effects of Dorema aucheri hydroalcoholic leave extract in streptozotocin-nicotinamide induced type 2 diabetes in male rats. Iran. J. Basic Med. Sci. 2014; 17: 808-14.
10. Miraghaee SS and Karimi I. Evaluation of the antioxidant and antimicrobial properties of Dorema aucheri plant. Iran. Red Crescent Med. J. 2012; 14: 684-5.
11. Yazdi FT, Behbahani BA, Vasiee A, Mortazavi SA and Yazdi FT. An investigation on the effect of alcoholic and aqueous extracts of Dorema aucheri (Bilhar) on some pathogenic bacteria in vitro. J. Paramed. Sci. 2015; 6: 58-64.
12. Wollenweber E, Dorr M and Rustiyan A. Dorema aucheri, the first umbelliferous plant found to produce exudate flavonoids. Phytochem. 1995; 38: 1417. [DOI:10.1016/0031-9422(94)00840-P]
13. Plochmann K, Korte G, Koutsilieri E, Richling E, Riederer P, Rethwilm A, Schreier P and Scheller C. Structure-activity relationships of flavonoid-induced cytotoxicity on human leukemia cells. Arch. Biochem. Biophys. 2007; 460: 1-9. [DOI:10.1016/j.abb.2007.02.003]
14. Mirzaei A, Mirzaei N and Ghavamizadeh M. Antioxidant activity and cytotoxicity of Dorema aucheri by Artemia urmiana: a brine shrimp lethality test. Life Sci. J. 2013; 10: 8-12.
15. Mosaddegh M, Naghibi F, Moazzeni H, Pirani A and Esmaeili S. Ethnobotanical survey of herbal remedies traditionally used in Kohghiluyeh va Boyer Ahmad province of Iran. J. Ethnopharmacol. 2012; 141: 80-95. [DOI:10.1016/j.jep.2012.02.004]
16. Mostafavi SH, Fazilati M, Mostafavi SA, Vahhabi MR, Mostafavi F, Omidvarinia S, Zandi-Atashbar N, Derakhshanian H and Hajipoor AR. Hepatotoxicity of Dorema aucheri (Bilhar) in albino mice. Arch. Iran. Med. 2013; 16: 530-2.
17. Ostad SN, Rajabi A, Khademi R, Farjadmand F, Eftekhari M, Hadjiakhoondi A and Khanavi M. Cytotoxic potential of Centaurea bruguierana ssp. belangerana: the MTT assay. Acta Med. Iran. 2016; 54: 583-9.
18. Goodarzi S, Nateghpour M, Asgharian P, Hadjiakhoondi A, Yassa N, Tavakoli S, Mirzaei J, Farivar L, Motevalli Haghi A and Tofighi Z. Antimalarial and cytotoxic activities of roots and fruits fractions of Astrodaucus persicus extract. Iran. J. Basic Med. Sci. 2017; 20: 1318-23.
19. Goodarzi S, Hadjiakhoondi A, Yassa N, Khanavi M and Tofighi Z. Essential oils chemical composition, antioxidant activities and total phenols of Astrodaucus persicus. Iran. J. Basic Med. Sci. 2016; 19: 159-65.
20. Tofighi Z, Es-haghi A, Maleki Asl M, Tajic AR, Saber Navai M, Tavakoli S, Hadjiakhoondi A and Yassa N. Investigation of chemical keys for relationship between plants and their unifloral honeys by hydrodistillation and SPME and biological activities of honeys. Eur. Food Res. Tech. 2014; 238: 665-73. [DOI:10.1007/s00217-013-2147-y]
21. Fennell CW, Lindsey KL, McGaw LJ, Sparg SG, Stafford GI, Elgorashi EE, Grace OM and Staden JV. Assessing African medicinal plants for efficacy and safety: pharmacological screening and toxicology. J. Ethnopharmacol. 2004; 94: 205-17. [DOI:10.1016/j.jep.2004.05.012]
22. Philomena G. Concerns regarding the safety and toxicity of medicinal plants - An overview. J. Appl. Pharm. Sci. 2011; 1: 40-44.
23. Popat A, Shear NH, Malkiewicz I, Stewart MJ, Steenkamp V, Thomson S and Neuman MG. The toxicity of Callilepis laureola, a South African traditional herbal medicine. Clin. Biochem. 2001; 34: 229-36. [DOI:10.1016/S0009-9120(01)00219-3]
24. Stewart MJ and Steenkamp V. Toxicology of African herbal remedies. South African Ethnobotany 2000; 1: 32-3.
25. Goodarzi S, Tabatabaei MJ, Mohammad Jafari R, Shemirani F, Tavakoli S, Mofasseri M and Tofighi Z. Cuminum cyminum fruits as source of luteolin-7-O-glucoside, potent cytotoxic flavonoid against breast cancer cell lines. Nat. Prod. Res. 2018; 22: 1-5. [DOI:10.1080/14786419.2018.1519824]
26. Mahdavi Gourabi A, Ostad Rahimi A, Sadeghi H, Afshoon T, Mahdavi R and Afshoon E. The Anti-breast tumors effects of Dorema aucheri plant (Bilhar plant) extract, margins of Zagros Mountains in Iran. Vitae Columbia. 2014; 21: 278-84.
27. Carocho M, Ferreira ICFR. The role of phenolic compounds in the fight against cancer - A review. Anticancer Agents Med. Chem. 2013; 13: 1236-58. [DOI:10.2174/18715206113139990301]

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:

ارسال پیام به نویسنده مسئول

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به فصلنامه علمی پژوهشی گیاهان دارویی می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2024 CC BY-NC 4.0 | Journal of Medicinal Plants

Designed & Developed by : Yektaweb