سال 11، شماره 43 - ( English 1391 )                   سال 11 شماره 43 صفحات 53-41 | برگشت به فهرست نسخه ها

XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Khalighi-Sigaroodi F, Ahvazi M, Yazdani D, Kashefi M. Cytotoxicity and Antioxidant Activity of Five Plant Species of Solanaceae Family from Iran. J. Med. Plants 2012; 11 (43) :41-53
URL: http://jmp.ir/article-1-141-fa.html
Khalighi-Sigaroodi F، Ahvazi ، Yazdani D، Kashefi M. Cytotoxicity and Antioxidant Activity of Five Plant Species of Solanaceae Family from Iran. فصلنامه گياهان دارویی. 1391; 11 (43) :41-53

URL: http://jmp.ir/article-1-141-fa.html


1- Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR ، khalighi@imp.ac.ir
2- Cultivation & Development Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
3- Pharmacognosy & Pharmaceutics Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
چکیده:   (5364 مشاهده)
 Background: The use of natural products as anticancer and antioxidant agents has a long history. Several drugs currently used in chemotherapy were isolated from plant species.
 Objective: The aim of this study was to evaluate cytotoxicity and antioxidant activity as well as phenol and flavonoid contents of five plant species of Solanaceae family.
 Methods: Five plant species of Solanaceae family were collected from different regions of Iran. Methanol extracts and chloroform fractions of these species were tested by brine shrimp lethality assay in order to detect cytotoxicity. Antioxidant activity was evaluated by DPPH method. The total phenol content was measured using Folin - Ciocalteu method. The flavonoid content was measured by a colorimetric assay.
 Results: The extracts of Datura innoxia and Datura stramonium showed the highest cytotoxicity activities with LC50 values of 22.08 and 21.66 μg/ml, respectively. The chloroform fractions of these two species were subjected to cytotoxicity assay with LC50 values of 33.00 and 4.29 μg/ml, respectively. In comparing, Solanum dulcamara showed the highest antioxidant activity with IC50 values of 52.51 μg/ml and the highest phenol and flavonoid content of the dry weight.
 Conclusion: It could be seen among five tested plant species that D. stramonium had the highest cytotoxic activity and S. dulcamara had the highest antioxidant activity, phenol and flavonoid content. Further studies are necessary for chemical composition of the extracts and more comprehensive biological assays.
 
واژه‌های کلیدی: Antioxidant، Cytotoxicity، Flavonoid، Phenol، Solanaceae
متن کامل [PDF 211 kb]   (3010 دریافت)    
نوع مطالعه: پژوهشی | موضوع مقاله: فارماكوگنوزی و فارماسيوتيكس
دریافت: 1391/1/28 | پذیرش: 1391/7/18 | انتشار: 1391/9/30

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

ارسال پیام به نویسنده مسئول


بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به فصلنامه علمی پژوهشی گیاهان دارویی می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2024 CC BY-NC 4.0 | Journal of Medicinal Plants

Designed & Developed by : Yektaweb