The anti-emetic effect of the aqueous and ethanolic extracts of Trachyspermum ammi fruit was studied in young chickens. Emesis was induced in the chickens using copper sulfate (60 mg/kg, orally) and ipecac (600 mg/kg, orally). The LD50 values of the aqueous and ethanolic extracts (i.p.) were 2753 mg/kg and 747 mg/kg in the chickens, respectively. The aqueous extract (800-2000 mg/kg, i.p.) and ethanolic extract (40-100 mg/kg, i.p.) significantly prevented the emesis induced by copper sulfate and ipecac. These results indicate that the extracts of T. ammi fruit extracts have an anti-emetic activity in young chickens with peripheral and central mechanisms.