year 6, Issue 21 (3-2007)                   J. Med. Plants 2007, 6(21): 20-25 | Back to browse issues page

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1- 1- Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran , souri@sina.tums.ac.ir
2- 1- Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
3- Razi Institute For Drug Research, Iran University For Medical Science’Tehran, Tehran, Iran
Abstract:   (6543 Views)
Background: Bradykinin has effects on histaminic response,vessels seepage,cellular reproduction,causing fever, pain and coughs caused by ACE controllers (3,4,6). Noscapin has controlled Bradykinins contractional effects on guinea pigs trachea and rats vazodofran (5,6). noscapin stops the secondary effects of eskimi in brains edema, with antagonizing the responses caused by Bradykinin (3,4,8). Objective: considering that opium’s alkaloids act as agonist of peptide systems like ankephalins and RAS, its interesting to know the effects of this alkaloids and among them Noscapine on B3 Bradykinin receptors on smooth muscle guinea pig trachea? Method: All variables are reported as mean and standard deviation.We have used pair test and the informations were processed by Excel, Statistical analysis with ANOVA (LSD) SPSS 9. Results: we took diagrams in to consideration and indicated that the contract ional effect of Bradykinin decreased dependent on density, in presence of three different amount of noscapines concentration. In this study we could demonstrate that noscapine interact with Bradykenin as a non competitive antagonist.
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Type of Study: Research | Subject: Pharmacognosy & Pharmaceutics
Received: 2014/12/1 | Accepted: 2014/12/1 | Published: 2014/12/1
* Corresponding Author Address: Razi Institute For Drug Research, Iran University For Medical Science’Tehran, Iran. P.O.Box: 14155-6183, Tel: (021) 88058696, Fax: (021) 88058719