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:: دوره 1، شماره 33 و S 6 - ( ويژه نامه شماره 6 (به زبان انگليسي) 1388 ) ::
جلد 1 شماره 33 و S 6 صفحات 57-65 برگشت به فهرست نسخه ها
Study of Hypoglycemic Effect of Juglans regia Leaves and its Mechanism
چکیده:   (2284 مشاهده)

  Background: Hypoglycemic effect of Juglans regia leaves was reported in other previous researches.

  Objective: To investigate the mechanism of hypoglycemic action of Julans regia Leaves Methanolic Extract (JRLME), we designed the following study.

  Methods: Male wistar rats were classified in five groups, each of six, including alloxan-induced diabetic rats treated with JRLME at doses of 250 (D+JRLMEa), 500 mg/kg (D+JRLMEb), Acarbose at dose 20 mg/kg (D+Ac), vehicle alone (DC) and normal rats treated with vehicle alone (NC). The Postprandial blood glucose level was examined in a short time (after a single dose treatment) and a long time (after three weeks daily treatment) model. After three weeks of treatment, all groups’ animals were killed to dissect pancreatic and myocardium for RNA extraction and RT-PCR, to assess insulin and glut-4 genes expression, respectively. In addition, other normal rats were killed to extract intestinal brush border membrane for α-glucosidase solution preparation. The effect of JRLMEa on α-glucosidase activity was evaluated by an in vitro method, compared to Acarbose as a reference drug.

  Results: The plant extract had a significant hypoglycemic action in both short and long term models. Decrease in PBG level was the most at 8 hour after treatment and more in D+Ac (53%), D+JRLMEa (40%) and D+JRLMEb (29%) versus DC, respectively. There was also permanent PBG reduction in treated groups in comparison with the DC one during long term period.

Conclusion: We did not find change in the insulin and glut-4 genes expression. On the other hand, the in vitro assay of α-glucosidase activity displayed inhibitory action of JRLME, like Acarbose, but less effectively.
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نوع مطالعه: پژوهشي | موضوع مقاله: فارماكوگنوزي
دریافت: ۱۳۹۳/۹/۱ | پذیرش: ۱۳۹۳/۹/۱ | انتشار: ۱۳۹۳/۹/۱
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Teimori M, Montasser Kouhsari S, Ghafarzadegan R, Hajiaghaee R. Study of Hypoglycemic Effect of Juglans regia Leaves and its Mechanism. JMP. 2010; 1 (33) :57-65
URL: http://jmp.ir/article-1-514-fa.html

Study of Hypoglycemic Effect of Juglans regia Leaves and its Mechanism. فصلنامه گياهان دارويي. 1388; 1 (33) :57-65

URL: http://jmp.ir/article-1-514-fa.html



دوره 1، شماره 33 و S 6 - ( ويژه نامه شماره 6 (به زبان انگليسي) 1388 ) برگشت به فهرست نسخه ها
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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