سال 23، شماره 90 - ( 3-1403 )                   سال 23 شماره 90 صفحات 104-94 | برگشت به فهرست نسخه ها


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Derakhshani A, Soltani S, Zarghami Moghaddam P, Mollazadeh S, Teymouri M. Anti-caries efficacy of the medicinal plant Miswak (Salvadora persica L.) and propolis Varnish on extracted human Premolar and Molar teeth. J. Med. Plants 2024; 23 (90) :94-104
URL: http://jmp.ir/article-1-3621-fa.html
درخشانی علی، سلطانی ساهره، ضرغامی مقدم پرستو، ملازاده سمانه، تیموری منوچهر. ارزیابی اثر ضد پوسیدگی وارنیش حاوی گیاه دارویی مسواک (Salvadora persica L.) و بره موم بر روی دندان‌های پرمولار و مولار استخراج شده انسان. فصلنامه گياهان دارویی. 1403; 23 (90) :94-104

URL: http://jmp.ir/article-1-3621-fa.html


1- دانشکده دندان پزشکی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران
2- مرکز تحقیقات فرآورده‎های طبیعی و گیاهان دارویی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران
3- مرکز تحقیقات فرآورده‎های طبیعی و گیاهان دارویی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران؛ گروه بیوتکنولوژی پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران
4- مرکز تحقیقات فرآورده‎های طبیعی و گیاهان دارویی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران؛ گروه نانوتکنولوژی پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران ، m.teymouri@nkums.ac.ir
چکیده:   (1988 مشاهده)
Background: Tooth decay is the result of the activity of cariogenic microorganisms that live in dental plaque. Among these, Streptococcus mutans is the main factor in the development and progression of dental tissue destruction. Objective: The study aims to investigate the anti-caries potential of a natural compound-based varnish against S. mutans on a set of dental specimens. Methods: Fifty-four extracted human molar and premolar specimens were procured from an outpatient clinic of pediatric dentistry, Bojnurd, Iran. These teeth were cast in a silicon putty and treated with a varnish made of propolis and miswak (from twigs of Salvadora persica L. tree) ethanolic extracts, followed by incubation in a harsh acidic medium (pH 2). Then, the density of samples, antibacterial activity, buffering capacity, and fluoride release were respectively investigated using radiography, disc diffusion and microdilution tests, and pH drop challenge in acetic acid solution (PH 4). Results: Overall, the varnishes protected the dental samples from dissolution in the acidic medium, as evidenced by the radiographic examination. The varnishes also exhibited remarkable antibacterial activity (inhibition zones of 3.2 ± 0.8 mm and 2.0 ± 0.2 mm for miswak and propolis varnish films), a considerable buffering capacity (pH increase from 4 to 7 within 5 minutes), and released fluoride (mean 85 µmoles). Conclusion: The application of natural compound-based varnish is strongly recommended for dental protection.
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نوع مطالعه: پژوهشی | موضوع مقاله: گياهان دارویی
دریافت: 1402/11/30 | پذیرش: 1403/7/28 | انتشار: 1403/8/5

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