Treatment strategies for AD will have to include a variety of interventions directed at multiple targets. So far, the outcomes with available approved medications for AD are often unsatisfactory, and there is a place for alternative medicine, in particular herbal medicine. Herbal medicines are being used by about 80% of the world population primarily in the developing countries for primary health care. They have stood the test of time for their safety, efficacy, cultural acceptability and lesser side effects. This review tries to summarize the studies regarding Ginkgo biloba, Salvia officinalis, Melissa officinalis and Crocus sativus in the treatment of Alzheimer’s disease.