Background: In traditional medicine “Crataegus melano carpa” is one of the medicinal plants that has many therapeutic effects. One of them is its effect on nerveous system.
Objective: Evaluation of Intracerebroventricular (ICV) injection of alcoholic extract of “Crataegus melano carpa” leaves on fear behavior in presence pentylenetetrazole (PTZ) in adult male rat.
Methods: Animals were divided into 3 groups: experimental, saline and, pentylenetetrazole (PTZ) 20 mg/kg as positive control (I.P). In the experimental group, the animals received 4000 µg/Rat alcoholic extract of “Crataegus melano carpa” leaves (ICV) and PTZ (I.P). Then plus maze was used for evaluation of the fear. Open arm entries percentage (%OAE) and open arm time percentage (%OAT) were evaluated.
Results: The results show that intracerebroventricular (ICV) injection of alcoholic extract of “Crataegus melano carpa” leaves increased %OAE and %OAT significantly (p<0.05).
Conclusion: We concluded that alcoholix extract of “Crataegus melano carpa” is effective on fear reduction in presence pentylenetetrazole (PTZ) in adult male rat.