سال 13، شماره 51 - ( English 1393 )                   سال 13 شماره 51 صفحات 70-62 | برگشت به فهرست نسخه ها

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Sharifzadeh M, Ebadi N, Manayi A, Kamalinejad M, Rezaeizadeh H, Mirabzadeh M, et al . Effect of Rubia tinctorum L. Extractson Carrageenan-Induced Paw Edema in Rats. J. Med. Plants 2014; 13 (51) :62-70
URL: http://jmp.ir/article-1-631-fa.html
Sharifzadeh M، Ebadi N، Manayi A، Kamalinejad M، Rezaeizadeh H، Mirabzadeh M، و همکاران.. Effect of Rubia tinctorum L. Extractson Carrageenan-Induced Paw Edema in Rats. فصلنامه گياهان دارویی. 1393; 13 (51) :62-70

URL: http://jmp.ir/article-1-631-fa.html


1- Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Traditional Pharmacy, Faculty of Traditional Medicine andPersian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
3- Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Pharmacognosy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5- Student Scientific Research Center, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Iran
6- Department of Traditional Pharmacy, Faculty of Traditional Medicine andPersian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran ، khanavim@tums.ac.ir
چکیده:   (5741 مشاهده)
Background: Inflammation is a dynamic process that is elicited in response to various harmful stimulantsthat may threaten the well-being of the host. Herbs have been traditionally used as anti-inflammatory agents since very early times. Rubia tinctorum L. is one of these herbs that havebeen used for treating inflammatory diseases in Iranian traditional medicine. Objective: This study aims at considering anti-inflammatory effects of R. tinctorum and comparing its extracts in this property. Methods: The root of Rubia tinctorum (Rubiaceae) was collected from Yazd province, in the center of Iran. The root extracts of plant were studied for their anti-inflammatory activity by using carrageenan-induced hind paw edema in Wistarmale rats. Indomethacin and normal saline were used as positive and negative controls, respectively. Different concentrations of aqueous, ethanolic, and 50% aq. ethanolic extracts (600, 800, 1000 mg/kg) were given orally before carrageenan injection. The paw thickness was measured at 1, 3 and 5 hours after injection. Results: Both, aqueous and 50% eq. ethanolic extracts reduced paw edema at 600 and 800 mg/kg concentrations. Moreover, ethanolic extract showed significant effect only in1sthour after carrageenan injection. Conclusion: The results indicated that the aqueous extract were exhibited higher anti-inflammatory effect compared with other extracts. Accordingly, the potent anti-inflammatory effect of the root extracts is attributed to the polar compounds which are extracted in the water.
واژه‌های کلیدی: Rubia tinctorum، Rubiaceae، Anti-inflammatory، Carrageenan، Paw edema
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نوع مطالعه: پژوهشی | موضوع مقاله: فارماكولوژی و سم شناسی
دریافت: 1393/2/27 | پذیرش: 1393/6/8 | انتشار: 1393/6/31

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