سال 8، شماره 29 و S5 - ( Supplement 5 (English) 1387 )                   سال 8 شماره 29 و S5 صفحات 78-70 | برگشت به فهرست نسخه ها

XML English Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Khaki A, Khaki A, Nouri M, Ahmadi-Ashtiani H, Rastegar H, Fathiazad F et al . Evaluation Effects of Quercetin on Liver Apoptosis in Streptozotocin-induced Diabetic Rat. J. Med. Plants 2009; 8 (29) :70-78
URL: http://jmp.ir/article-1-542-fa.html
Khaki AA، Khaki A، Nouri M، Ahmadi-Ashtiani HR، Rastegar H، Fathiazad F و همکاران.. Evaluation Effects of Quercetin on Liver Apoptosis in Streptozotocin-induced Diabetic Rat. فصلنامه گياهان دارویی. 1387; 8 (29) :70-78

URL: http://jmp.ir/article-1-542-fa.html

Evaluation Effects of Quercetin on Liver Apoptosis in Streptozotocin-induced Diabetic Rat
AA Khaki* 1، A Khaki2 ، M Nouri3 ، HR Ahmadi-Ashtiani4 ، H Rastegar5 ، F Fathiazad6 ، M Ghanbari7
1- Department of Anatomy, Islamic Azad University, Branch Bonab, Iran
2- Department of Veterinary Pathology Islamic Azad University, Branch Tabriz, Tabriz, Iran
3- Department of Biochemistry, Tabriz Medical Sciences University, Tabriz, Iran
4- Biochemistry & Nutrition Department of Zanjan Medical University, Clinical Biochemistry, Tarbiat-e-Modarres University, School of Medical Science, Department of Clinical Biochemistry, Tehran, Iran
5- Ministry of Health and Medical Education, Food & drug laboratory Research Center, FDLRC, Tehran, Iran
6- Department of Pharmacognosy. Tabriz Medical Sciences University, Tabriz, Iran
7- Medical student, Tabriz Medical Sciences University
چکیده:   (4714 مشاهده)

Background: Quercetin is a strong antioxidant and long-term treatment of STZ-diabetic animals and it has been shown to reduce oxidative stress.

Objective: Antioxidants have essential effect on spermatogenesis and sperm parameters. Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus.

Methods: Wistar male rat (n=40) were allocated into three groups, control group (n=10) and Quercetin (QR) group that received 15mg/kg (IP) QR, (n=10), and Diabetic group that received 55mg/kg (IP) streptozotocin (STZ) (n=20) which was subdivided to two groups of 10 STZ group and treatment group. Treatment group received 55mg/kg (IP) STZ plus15mg/kg QR, daily for,4 weeks, respectively however, the control group just received an equal volume of distilled water daily(IP) . Diabetes was induced by a single (IP) injection of streptozotocin (55mg/kg) .Animals were kept in standard condition. In 28day after inducing diabetic 5cc blood were collected for TAC,MDA and Ox-LDL levels and Liver tissues of Rat in whole groups were removed then prepared for Apoptosis analysis by Tunel method.

Results: Apoptotic cells significantly decreased in group that has received 15mg/kg (IP) Quercetin (P<0.05) in comparison to experimental groups (P<0.05).

Conclusion: Since in our study 15mg/kg (IP) Quercetin have significantly Preventive effect on liver cells damages by reducing number of Apoptotic cells in liver, so it seems that using it can be effective for treatment in Diabetic Rat.
واژه‌های کلیدی: Apoptosis، Diabetic، Quercetin، Streptozotocin، Liver، Rat
متن کامل [PDF 667 kb]   (2929 دریافت)    
نوع مطالعه: پژوهشی | موضوع مقاله: فارماكولوژی و سم شناسی
دریافت: 1387/9/1 | پذیرش: 1387/12/5 | انتشار: 1388/3/31
ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA
بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به فصلنامه علمی پژوهشی گیاهان دارویی می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2024 CC BY-NC 4.0 | Journal of Medicinal Plants

Designed & Developed by : Yektaweb