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جلد 1 شماره 29 و S5 صفحات 39-44 برگشت به فهرست نسخه ها
Taxane Diterpenoids from Taxus baccata L. Growing in Iran
چکیده:   (1466 مشاهده)

  Background: There are eight Taxus species and two hybrids in the world and Taxus baccata L. (European yew) is the single representative in Iran. Until now, a large number of taxoids possessing different skeleton systems, as well as lignans, flavonoids, steroids and sugar derivatives have been isolated from various Taxus species. Taxoids are highly oxygenated diterpenes isolated from different species of yew trees (family Taxaceae). They have received considerable attention after the discovery of the clinical efficacy of paclitaxel against different cancers due to its remarkable inhibition of microtubules polymerization leading to apoptosis of cancer cells.

  Objective: This study was conducted for extraction, purification and identification of taxoids occurring in the aerial parts of Taxus baccata L. growing in Iran.

  Methods: The plant materials were extracted with organic solvent and after defatting, partitioning, column chromatography and thin layer chromatography steps, the obtained compounds were characterized on the basis of spectral data.

  Results: Two taxane diterpenoids were isolated. The structures of these taxoids were established as 5-Cinnamoyl-10-acetyltaxicin-I and 2-Deacetyltaxinine E on the basis of spectral analysis.

Conclusion : These two taxoids were not previously encountered in Taxus baccata L. species.
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نوع مطالعه: پژوهشي | موضوع مقاله: شيمي دارويي
دریافت: ۱۳۹۳/۹/۲ | پذیرش: ۱۳۹۳/۹/۲ | انتشار: ۱۳۹۳/۹/۲
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Hadjiakhoondi A, Pirali - Hamedani M, Verdian-Rizi M, Rezazadeh S. Taxane Diterpenoids from Taxus baccata L. Growing in Iran. JMP. 2009; 1 (29) :39-44
URL: http://jmp.ir/article-1-533-fa.html
Taxane Diterpenoids from Taxus baccata L. Growing in Iran. فصلنامه گياهان دارويي. 1387; 1 (29) :39-44

URL: http://jmp.ir/article-1-533-fa.html

دوره 1، شماره 29 و S5 - ( ويژه نامه شماره 5 (به زبان انگليسي) 1387 ) برگشت به فهرست نسخه ها
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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