سال 24، شماره 94 - ( 4-1404 )
سال 24 شماره 94 صفحات 18-1 |
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Falahatzadeh M, Sobhani Z, Zomorodian K, Hashemi S S, Zarshenas M M. Topical formulation of a skin-natural wound healing remedy based on Traditional Persian Medicine. J. Med. Plants 2025; 24 (94) :1-18
URL: http://jmp.ir/article-1-3717-fa.html
URL: http://jmp.ir/article-1-3717-fa.html
Topical formulation of a skin-natural wound healing remedy based on Traditional Persian Medicine. فصلنامه گياهان دارویی. 1404; 24 (94) :1-18
چکیده: (1711 مشاهده)
Background: Historical documents highlight various multifocal products for wound management, including the Zaroor Arbaee formulation, which comprises Commiphora myrrha, Boswellia sp., Astragalus fasciculifolius, and Dracaena sp. Objective: This study investigates a novel topical formulation for skin wound healing based on Traditional Persian Medicine, emphasizing these botanicals. Methods: A methanol extract was prepared, and an MTT assay was used to assess cytotoxicity on normal liver cells. Antimicrobial activity was evaluated using the microdilution method according to CLSI guidelines. A 5% topical cream was formulated, and total phenolic, flavonoid, and tannin contents were measured via spectrophotometry. High-performance thin-layer chromatography (HPTLC) was employed for phytochemical profiling, and essential oil extraction was performed to identify volatile constituents. Organoleptic and physicochemical tests were also conducted on the cream. Results: The MTT assay showed no cytotoxicity, and antimicrobial tests confirmed significant antifungal activity. Total phenolic, flavonoid, and tannin contents were 7.59 ± 0.31 mg, 0.54 ± 0.007 mg, and 2.07 ± 0.13 mg per 1.5 g of extract in a 30 g cream, respectively. Essential oil analysis identified furanoeudesma-1,3-diene (32.84%) and curzerene (14.94%) as major constituents. Additional assessments confirmed the cream’s stability and spreadability. Conclusion: Zaroor Arbaee appears to be a promising traditional remedy for skin wound healing.
نوع مطالعه: پژوهشی |
موضوع مقاله:
فارماكوگنوزی و فارماسيوتيكس
دریافت: 1403/5/13 | پذیرش: 1404/3/19 | انتشار: 1404/4/10
دریافت: 1403/5/13 | پذیرش: 1404/3/19 | انتشار: 1404/4/10
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