سال 19، شماره 73 - ( زبان: انگلیسی 1398 )                   سال 19 شماره 73 صفحات 119-132 | برگشت به فهرست نسخه ها


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Mohseni I, Peeri M, Azarbayjani M A. Dietary supplementation with Salvia officinalis L. and aerobic training attenuates memory deficits via the CREB-BDNF pathway in amyloid beta- injected rats. J. Med. Plants. 2020; 19 (73) :119-132
URL: http://jmp.ir/article-1-2344-fa.html
محسنی ایمان، پیری مقصود، آذربایجانی محمد علی. اثر تمرین هوازی وعصاره هیدرومتانلی مریم‌گلی (Salvia officinalis) بر حافظه، بیان CREB و BDNF در آلزایمر القا شده با بتا آمیلوئید. فصلنامه گياهان دارویی. 1398; 19 (73) :119-132

URL: http://jmp.ir/article-1-2344-fa.html


1- گروه فیزیولوژی ورزشی، دانشگاه آزاد اسلامی واحد تهران مرکزی
2- گروه فیزیولوژی ورزشی، دانشگاه آزاد اسلامی واحد تهران مرکزی ، m.peeri@iauctb.ac.ir
چکیده:   (582 مشاهده)
مقدمه: بیماری آلزایمر اختلال زوال نورونی وابسته به سن بوده و تجمع آمیلوئید بتا، خصوصاً در ناحیه هیپوکامپ مهم‌ترین علت مرگ نورون‌ها در این بیماری است. فعالیت بدنی و داروهای گیاهی می‌تواند در پیشگیری و درمان اختلالات زوال نورونی مؤثر باشد. هدف: این مطالعه با هدف تعیین تأثیر تمرین هوازی و عصاره خوراکی مریم‌گلی بر حافظه، بیان (CREB) و فاکتور مشتق از نوروتروفیک مغز (BDNF) در موش‌های صحرایی مدل آلزایمری تیمار شده با بتا آمیلوئید، اجرا شد. روش بررسی: در یک کارآزمایی تجربی 32 سر رت نر تحت تزریق بتا آمیلوئید (ng/μl 10) قرار گرفتند و به صورت تصادفی در گروه‌های کنترل، تمرین هوازی، عصاره و تمرین هوازی - عصاره قرار گرفتند. پس از 21 روز، گروه عصاره
mg/kg 100 عصاره مریم‌گلی را به صورت گاواژ دریافت کردند. گروه‌های تمرینی نیز چهار هفته روی تردمیل دویدند. بعد از اتمام دوره مداخله، از ماز آبی موریس جهت ارزیابی حافظه فضایی استفاده شد. CREB و BDNF با روشRealtime PCR  اندازه‌گیری شد و همچنین ارزیابی بافت‌شناسی جهت بررسی میزان تجمع پلاک‌های بتا آمیلوئید در بافت مغز صورت گرفت. نتایج: نتایج نشان داد عصاره مریم‌گلی و دویدن روی تردمیل، سبب بهبود یادگیری و حافظه شد، سطوح (001/0 CREB P=) (001/0 BDNF P=) در آزمودنی‌های آلزایمر القاء شده در مقایسه با گروه کنترل افزایش معنی‌دار یافت، چگالی سلول‌های عصبی، به طور قابل ملاحظه‌ای در گروه‌های دونده روی تردمیل و دریافت‌کننده عصاره نسبت به گروه کنترل افزایش معنی‌داری داشت (001/0 P=). نتیجه‌گیری: نتایج مطالعه حاضر نشان داد تمرین هوازی و عصاره مریم‌گلی اثر هم‌افزایی بر بهبود حافظه، نقص عصبی و چگالی سلول‌های عصبی در شرایط آلزایمر القا شده با بتا آمیلوئید دارد. لذا استفاده همزمان این دو مداخله پیشنهاد می‌شود.
متن کامل [PDF 885 kb]   (235 دریافت)    
نوع مطالعه: پژوهشی | موضوع مقاله: فارماكولوژی و سم شناسی
دریافت: 1397/8/17 | پذیرش: 1397/10/18 | انتشار: 1399/3/17

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