سال 10، شماره 39 - ( English 1390 )                   سال 10 شماره 39 صفحات 22-32 | برگشت به فهرست نسخه ها

XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rastegar Moghadam B, Ali-Beig H, Arbabian S, Farahbakhsh S, Emami F, Golmanesh L, et al . Effect of Aqueous Extract of Trigonella foenum-graecum on Pain and Inflammation Induced by Formalin in Male Mice. J. Med. Plants. 2011; 10 (39) :22-32
URL: http://jmp.ir/article-1-198-fa.html
Rastegar Moghadam B، Ali-Beig H، Arbabian S، Farahbakhsh Sh، Emami F، Golmanesh L، و همکاران.. Effect of Aqueous Extract of Trigonella foenum-graecum on Pain and Inflammation Induced by Formalin in Male Mice. فصلنامه گياهان دارویی. 1390; 10 (39) :22-32

URL: http://jmp.ir/article-1-198-fa.html


1- Department of Biology, School of Science, AZAD Islamic University, Tehran North Branch
2- Neurosciences Research Center, Baqyiatallah Medical Sciences University, Tehran
3- Department of Physiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences
4- Department of Anatomy, Faculty of Medicine, Kermanshah University of Medical Sciences
5- Neurosciences Research Center, Baqyiatallah Medical Sciences University ، h.sahraei@bmsu.ac.ir
چکیده:   (3469 مشاهده)
Background: Studies have emphasized the effect of Trigonella foenum-graecum extract on the reduction of pain and inflammation. Objective: In this research we investigated the mechanisms of Trigonella foenum-graecum extract in reducing pain and inflammation induced by formalin. Methods: Male Albino mice (weight 20 - 25 g) were evaluated through the injection of 2 microliters of formalin to the plantar part of right foot. Following this, the rate of animal foot pain and inflammation were measured using Dubbison-Dennis and immersion in mercury. Trigonella foenum-graecum extract was injected 30 minutes before administration of formalin to the animals intraperitoneally. In addition, blood samples were taken from animals and corticosterone concentrations were measured. In an in vitro study the effect of extract on the activity of cyclooxygenase type 1 and 2 was assessed. Results: Our results showed that Trigonella foenum-graecum extract inhibits the first and second phase of pain induced by formalin, while inflammation is slightly reduced. Also the effect of Trigonella foenum-graecum extract is reversible with naloxone or memantine administration. Also Trigonella foenum-graecum extract could not increase plasma corticosterone level and was ineffective in activity of cyclooxygenase type 1 and 2 enzyme. Conclusion: Although Trigonella foenum-graecum extract can inhibit pain induced by formalin administration, but it seems that the reduction of pain is due to the possible interaction of components of Trigonella foenum-graecum extract with opioid and/or glutamate systems which occurs in the body and the mechanisms of inflammation reduction are not activated by the extract.
متن کامل [PDF 93 kb]   (1561 دریافت)    
نوع مطالعه: پژوهشی | موضوع مقاله: فارماكولوژی و سم شناسی
دریافت: 1388/11/6 | پذیرش: 1390/2/21 | انتشار: 1390/6/31

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

ارسال پیام به نویسنده مسئول


بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به فصلنامه علمی پژوهشی گیاهان دارویی می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2021 CC BY-NC 4.0 | Journal of Medicinal Plants

Designed & Developed by : Yektaweb