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Rahmani Gohar M, Moslemi H, Kafshdouzan K, Mazaheri Nezhad Fard R. Antibacterial Activity of Origanum vulgare on Staphylococcus aureus in a Rat Model of Surgical Wound Infection. J. Med. Plants 2016; 15 (57) :19-24
URL: http://jmp.ir/article-1-1290-fa.html

Background: Wound infection is one of the frequent complications in patients with surgical operations. Staphylococcus aureus is the most common cause of surgical wound infections. Origanum vulgare, a common culinary herb, has been shown to have strong antimicrobial activity, especially against Gram-positive pathogens.
Objective: This study was designed to investigate the antibacterial effects of O. vulgare on S. aureus in surgical wounds using a rat model.
Methods: Twenty male Sprague-Dawley rats were divided randomly into two groups of treatment and control rats (1:1). A circular incision was made on the dorsal inter-scapular region of each rat. Then, rats were inoculated topically with 1 × 10⁴ CFU of S. aureus at the site of skin wounds. O. vulgare extract was applied to wounds twice a day during the experiment. Animals of the control group were left untreated.
Results: The load of bacteria in untreated rats was 7 × 10⁶ ± 6 CFU/wound while this was 2 × 10⁵ ±1 CFU/wound for the treatment animals, which was significantly lower.
Conclusion: Results have showed that topical application of O. vulgare extract on the infected wounds included significant antibacterial activity against S. aureus.