Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
A Review on Therapeutic Effects of Tribulus terrestris
1
22
OTHER
L
Naseri
Ph.D. Candidate of Anatomical Sciences, Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
M
Akbari bazm
Ph.D. Candidate of Anatomical Sciences, Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
M
Khazaei
Ph.D. of Anatomical Sciences, Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Tribulus terrestris is a one-year-old herb dispersed in hot and humid areas in the Mediterranean and warm regions of Europe, Asia, Africa and Australia. This plant has many benefits and is used in traditional medicine for the treatment of various diseases, including kidney stones, low blood pressure, anti-diabetic properties, and treatment of cardiovascular diseases, gastrointestinal disorders, and sexual performance in men and in treatment of hepatitis is recommended. The aim of this study was to investigate the pharmacological and therapeutic properties of pharynx in traditional medicine and scientific papers in modern medicine. This study is a systematic review based on the PRISMA checklist. Based on keywords, 440 titles were selected and after removing repetitive articles, 129 papers were extracted from various databases including PubMed, SID, ScienceDirect, Scopus and Magiran, and the Google Scholar search engine without time limit. T. terrestris has several properties, including antimicrobial, antibacterial, free radicals purification and inhibition of lipid peroxidation, and through various mechanisms of cell and molecules, it produces various pharmacological and therapeutic properties. One of the most important therapeutic properties of this plant is its anti-inflammatory and anti-cancer properties. Also, several clinical studies have shown that co-administration of tetanus extract with chemotherapy drugs reduces the side effects of drugs. Due to the lack of toxicity and side effects of T. terrestris, the use of herbs has been considered as a complementary drug in diet regimens for various diseases.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
Role of Medicinal Herbs in the Development of Renal Adverse Effects: A Review Study
23
45
OTHER
E
Abdollahi
Department of Pharmacology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
M
Khodaparast
Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran
F
Kiashi
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
M
Hoormand
Department of Pharmacology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
The use of herbal medicines dates back to the beginning of the human history. Today, herbal medicines still play a significant role in the prevention and treatment of disease in many cultures and communities. There are few reports about adverse effects of herbal medicines. This is why many people around the world believe that herbal medicines can't cause adverse effects. They believe plants are safe, even if they're not efficient. This idea is wrong, regardless of how common it might be considered. Plants can be dangerous and even lethal in some cases. It is not just plant chemicals that might cause adverse effects. The role of environmental pollutants and the presence of fraud in form of alternation and adulteration in herbal preparations is another factor that might contribute to harmful effects on various organs of the body, including the kidneys. Kidneys are vital organs that filter blood, remove wastes and excrete the wastes in the urine. They are susceptible to injury because of their high exposure to different chemical substances including chemicals from the herbs. This is why studying the possible adverse effects of herbal medicines on kidney structure and function gets important. This issue highlights the role of regulatory and legislator organizations in providing up-to-date laws to help maintain a better regulation on the production and consumption of herbal products. This article reviews the findings on this case. We used papers published between 1990 and January 2018 in pubmed and google scholar databases.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
A Complete Review on the Genus Vaccinium and Iranian Ghareghat
46
65
FA
T
Hasanloo
Department of Molecular Physiology, Agricultural Biotechnology Research Institute of Iran, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran
M
Jafarkhani Kermani
Department of Tissue and Cell Culture, Agricultural Biotechnology Research Institute of Iran and Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran
YA
Dalvand
Department of Molecular Physiology, Agricultural Biotechnology Research Institute of Iran, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran
Sh
Rezazadeh
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran *Corresponding author: Agricultural Biotechnology Research Institute of Iran, Mahdasht Road, P.O.Box: 31535-1897, Karaj, Iran
In recent years due to the demonstration of destructive side effects of chemical drugs, utilizing herbal drugs to treat diseases have increased. The medicinal Vaccinium is one of the popular plants which have many pharmaceutical, food and industrial values. There are about 100 species of this genus around the world but Ghare-Ghat (Vaccinium arctostaphlyus) is the only species present in Iran which has been reported in six regions of the country. The major metabolites in the leaves and fruits of Ghare-Ghat are phenols, especially anthocyanins, which have antioxidant properties. The fruit essence contains 30% sugar, 5.15% protein, 1.5% fat and the young shoots contain hexadecanoic acid, vitispirane Beta-ionone and sandaracopimaradiene. In Iranian traditional medicine, fruit infusion has been used to reduce blood sugar and blood pressure. Due to high levels of acid in Ghare-Ghat it has antibacterial effects and is used to treat bladder infections. It also has anti cyanosed compounds which help in the formation of stronger capillaries and reduction of the stickiness of blood platelets. Today, with the remarkable advances of biotechnology including tissue culture, access to high quality and quantity of products of this genus has increased. The genus Vaccinium and in particular Ghare-Ghat has high economic value in Iran and requires further study to increase its cultivation and production of food and pharmaceutical products.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
The Prophylactic Effect of Cuminum cyminum Extract on Gastric Residual Volume in Traumatic Patients under Ventilator Hospitalized in Intensive Care Unit
66
80
OTHER
SR
Babaei-Abandansari
Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
M
Bagheri-Nesami
Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran
A
Gholipour-Baradari
Department of Anesthesiology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
J
Yazdani-cherati
Health Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
SS
Yosefi
Department of Traditional Persian Medicine, Traditional and Complementary Medicine, Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran
Background: Increased Gastric residual volume (GRV) is one of the common problems in ICU.
Objective: The aim of this study was to determine the effect of cumin extract on gastric residual volume in patients with traumatic episodes hospitalized in ICU.
Method: This double-blind randomized clinical trial was conducted on 60 patients traumatic hospitalized in ICU. Patients were randomly assigned to one of two groups: cumin (n = 30) and distilled water (n = 30). In the intervention group, 6 grams of cumin extract in 3 divided doses were given 50 drops in 30 cc of urban water at 3 times every 8 hours after. The remaining volume was recorded for up to 4 consecutive days and the data were compared in two groups. (IRCT: 201610297494N24).
Results: Before the intervention, there was no significant difference between the mean GRV in the cumin group and placebo group (P = 0.63). Comparing the two groups of placebo and placebo, there was no significant difference in the amount of residual stomach in hospitalized patients with ICU on the first day (P = 0.13), but on the second, third and fourth days, this difference was significant between the two groups (p = 0.001).Comparing the two groups of intervention and placebo, the average volume of residual stomach before and during 4 consecutive days after intervention was significant (P = 0.001).
Conclusion: The results of this study showed that cumin extract was effective in decreasing residual stomach volume in hospitalized patients with ICU in comparison with placebo.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
Changes in Essential Oil Content and Composition of Peppermint (Mentha piperita L.) in Responses to Nitrogen Application
81
97
OTHER
M
Seif Sahandi
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
H
Naghdi Badi
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
A
Mehrafarin
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
F
Khalighi-Sigaroodi
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
M
Sharifi
Department of Plant Biology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
Background: Nitrogen is the most important nutrient requirement for plants. Nitrogen supplying affected the leaf area, carbon fixation, glandular trichomes formation, ATP and NADPH content which resulted to the terpenoids biosynthesis enhancement and essential oils accumulation.
Objective: This study was aimed to evaluate changes of essential oil content and components by use different levels of Urea fertilizer and its relation with the antioxidant status of peppermint.
Method: The two field experiments were conducted on randomized complete block design at 2013 and 2014. The treatments consisted of three levels of nitrogen fertilizer (urea) (0, 75, and 150 kg ha-1). The evaluated traits were included antioxidant enzymes, essential oil percentage and essential oil components.
Results: The urea fertilizer had a significant effect (P≤0.01) on the soluble protein amount and antioxidant enzymes activity. Urea consumption in the both years increased the peppermint essential oil content. The interaction of nitrogen fertilizer and year had a significant effect on most of the essential oil components excepted to β-pinene, myrcene, Limonene, 1,8- Cineole, Z-β- Ocimene, and α- Terpineol.
Conclusion: Using nitrogen fertilizer increased the peppermint essential oil content. Also, nitrogen deficiency reduced the soluble proteins and essential oil content and in contrast, it increased antioxidant enzymes activity and pulegone content. Therefore, consumption of 75 kg urea per hectare is recommended due to increasing essential oil content, decreasing pulegone rate, and no significant effect on menthol, menthone, and menthofuran contents.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
The Effect of Ginger on Primary Dysmenorrhea in Students of Qazvin University of Medical Sciences
98
106
OTHER
H
Pakniat
Department of Obstetrics and Gynecology, Faculty of Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
ES
Hajiseyed Javadi
Department of Obstetrics and Gynecology, Faculty of Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
Z
Golmohammadi
Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
M
Ashrafi
Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
Background: Dysmenorrhea is a major individual and public health problem in women. Recently, according to the high prevalence of dysmenorrhea, different medical treatments including herbal medicines have been used.
Objective: The aim of this study is to evaluate the effect of ginger on dysmenorrhea severity in students in Qazvin University of Medical Science, Iran.
Methods: In this randomized clinical trial, 100 female students aged 18 to 25 years with moderate to severe dysmenorrhea were included. The participants were allocated to two groups of control and intervention by randomization. The intervention group were received 500 mg of ginger tablet and 250 mg of Mefenamic Acid capsule twice a day and the control group took placebo and Mefenamic Acid 250 mg capsule two times a day from two days before and within the first three days of the onset of the Menstrual period. Pain intensity were measured with VAS tool before and two months after the prescription of drugs.
Results: The results of our study showed the pain intensity after the intervention in the first month, was significantly less than the control group (3.72 vs 5.44) (P<0.001) and in the second month, the pain in intervention group was significantly less than the control group (3.2 vs5.2) (P<0.001), and no complications were observed in the intervention group.
Conclusion: The result of this study indicated that herbal medicine like ginger has a great effect on reduction of dysmenorrhea severity and furthermore studies are suggested to perform in order to find a suitable dose of ginger for complete treatment of dysmenorrhea and other menstrual symptoms.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
Therapeutic application of Achillea millefolium L. in female reproductive diseases from the viewpoint of Persian medicine and current medicine
107
121
FA
Somayeh
Zakeri
Student Research Committee, Babol University of Medical Sciences, Babol, Iran
Narjes
Gorji
Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Reihaneh
Moeini
Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
zahra
Memariani
Department of History of Medical Sciences, School of Persian Medicine, Babol University of medical sciences, Babol, Iran
Introduction: In Persian medicine (PM), Achillea millefolium L. has a wide range of applications in the treatment of several diseases. The aim of this study is to introduce the viewpoints of PM scholars about this herb in the field of female diseases and to compare them with the recent studies.
Methods: In this review study, therapeutic applications of Achillea millefolium in the field of female diseases were collected from credible Persian medical sources from 4th to 14th lunar centuries then current scientific databases such as PubMed and Google scholar were searched by using key world Achillea millefolium for collecting the findings of clinical, experimental and in vitro studies about this herb in the field of obstetrics and gynecology to compared to the PM scholars' viewpoints.
Results: in PM, Achillea millefolium is recommended for treatment various female reproductive diseases such as menstrual disorders, facilitating labor, reducing adhesions of cervix, controlling uterine infections. In recent studies, therapeutic effects of this herb on ovarian cyst, menstrual cycle regulation and dysmenorrhea have been reported. Also, in several studies, the antibacterial and antifungal effects of this plant on controlling infections have been investigated; as well the extract of this plant has been effective in inhibiting the proliferation of ovarian adenocarcinoma cells.
Conclusion: Considering the extensive uses of Achillea millefolium reflected in PM and recent studies, it seems that this plant can be used in many fields of female diseases to provide ideas for research and therapy
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
Effect of Jasmonic Acid on Physiological and Phytochemical Attributes and Antioxidant Enzymes Activity in Safflower (Carthamus tinctorius L.) under Water Deficient
122
134
FA
R
Khademian
Genetics and Plant Breeding Department, Agriculture and Natural Resources Faculty, Imam Khomeini International University, Qazvin, Iran
M
Ghorbani Nohooji
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
B
Asghari
Department of Horticultural Sciences Engineering, Agriculture and Natural Resources Faculty, Imam Khomeini International University, Qazvin, Iran
Background: Safflower (Carthamus tinctorius L.), is an important medicinal plant of Asteraceae family, which is a rich source of pharmaceutically active compounds including phenols, flavonoids and fatty acids. In traditional medicine this plant has been used as an herbal medicine to treat various diseases.
Objective: The aim of this study was to evaluate the role of jasmonic acid to protect safflower against drought damages.
Method: The greenhouse experiment was conducted as a factorial experiment in a completely randomized design with three replications. The first factor was irrigation regime, which was applied at four levels: field capacity (FC), 0.8 FC, 0.6 FC and 0.4 FC. The second factor was application of jasmonic acid in three concentrations (0, 0.5 and 1 mM).
Results: According to the obtained results activities of antioxidant enzymes including catalase, superoxide dismutase and glutathione peroxidase, and also the amount of compounds like abscisic acid, proline, malondealdehyde, protein, phenols and flavonoids contents were significantly increased in safflower by enhancement of water stress. Conversely, relative leaf water content (RWC) exhibited a significant decrease due to water deficit. According to the obtained results, application of jasmonic acid can mitigate the adverse effect of drought stress on the mentioned attributes. Also, the amount of main fatty acids in the oil were significantly changed due to water deficient.
Conclusion: The results illustrated that jasmonic acid has an important role in increasing safflower ability to cope against drought stress through improvement of antioxidant enzymes activities and enhancement of secondary methabolites.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
Protective and Therapeutic Effect of Oleoresin of Pistacia atlantica in Acetic Acid-induced Colitis in Rat
135
148
FA
S
Farokhi
Students Research Committee, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
GhR
Bahrami
Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
A
Babaie
Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
MH
Farzaei
Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
Background: Ulcerative colitis is an idiopathic chronic, relapsing inflammation of the colon which is resulted from dysregulation of the mucosal immune system. In Iranian traditional medicine, oleoresin from Pistacia atlantica is used to treat gastrointestinal disorders, including peptic ulcers, dyspepsia and intestinal inflammation.
Objective: In this study, we examined the therapeutic and protective effects of oleoresin in acetic acid-induced colitis in rat.
Methods: The oleoresin was dissolved in Tween 80% (1% v / v) and doses of 100, 200 and 400 mg/kg were administered orally to animals. Three days after colitis induction, the rats were treated for 6 days and after determining the most effective dose in the treatment, the protective effect was evaluated using the optimal dose of the oleoresin for 6 days. In day 6, colitis was induced and continued for 3 days. At the end, animals were sacrificed for microscopic and macroscopic examination of colon tissues.
Results: Dose dependently, Oleoresin of P. atlantica showed therapeutic effects on microscopic and macroscopic examination of colon tissue of rats with ulcerative colitis induced by acetic acid, in comparison with control group(P<0.05). However, there was no significant difference between treatment groups and the control in the protective method (P>0.05).
Conclusion: This study showed the beneficial effects of anti-inflammatory and wound healing oleoresin of P. atlantica in acetic acid- induced ulcerative colitis in rats.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
Therapeutic Effects of Hesperetin and Nano Hesperetin on Ketamine-Induced Hepatotoxicity
149
159
FA
A
Hajizadeh Moghadam
Associate Professor of Animal Physiology, Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran
M
Parhizkar
M.Sc of Animal Physiology, Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran
R
Sirafi
Assistant Professor, Department of Pathobiology, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran
S
Khanjani Jelodar
PhD student of Animal Physiology, Department of Animal Biology, Faculty of Biology Sciences, Shahid Beheshti University, Tehran, Iran
Background: Ketamine (KET) causes oxidative stress and liver damage. Hesperetin plays an important role in the prevention of inflammatory processes and associated with oxidative stress.
Objective: The purpose of this study was to analyze the protective role of hesperetin and its nanocrystal on hepatotoxicity induced by ketamine in mice.
Methods: In this research, 30 male mice were divided into six groups: control, poisoned (KET 10 mg/kg/10 day injected intraparitary), hesperetin and hesperetin nanoparticles treated poisoning groups (10 and 20 mg/kg for four weeks orally after KET administration). Finally, the malondialdehyde (MDA) and glutathione (GSH) levels, Catalase (CAT), Superoxide dismutase (SOD), Glutathione peroxidase (GPX) and Glutathione reductase (GRX) activity in liver tissue as well as the its histological changes were investigated.
Results: The level of GSH and antioxidant enzyme activity in the liver were significantly
(P <0.05) decreased in the ketamin indused rat, and hesperetin and its nano significantly were increased (P <0.01) GSH level and antioxidant enzyme activity. In contrast, MDA level in the liver was significantly (P <0.01) increased in the the ketamin poioned rat, and nano hesperetin suppressed the ketamin-induced lipid proxidation. Ketamine also decreased number of hepatocytes (P<0.001) and diameter of sinusoids (P <0.05) in toxic mice. Whereas, Nano hesperetin increased antioxidant enzymes activities, diameter and nucleus diameter of hepatocytes and decreased MDA level (P <0.05).
Conclusion: The results of this study indicated that hesperetin and especially nano hesperetin due to antioxidant effects cause hepatoprotective against KET-induced oxidative stress.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
Effect of Gamma Irradiation on Growth and Trigonelline Content in Hairy Root of Iranian Fenugreek (Trigonella foenum-graecum L.)
160
169
FA
R
Ashrafi Parchin
Department of Plant Breeding and Biotechnology, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran
AA
Nasrollah Nezhad Ghomi
Department of Plant Breeding and Biotechnology, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran
H
Naghdi Badi
Medicinal Plants Research Centre, Institute of Medicinal Plants, ACECR, Karaj, Iran
A
Eskandari
Nuclear Agriculture Research School- Nuclear Science and Technology Research Institute, Karaj. Iran
S
Navabpour
Department of Plant Breeding and Biotechnology, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran
A
Mehrafarin
Medicinal Plants Research Centre, Institute of Medicinal Plants, ACECR, Karaj, Iran
Background: Fenugreek is a valuable medicinal plant and it is essential to investigate induction of mutations in order to increase its active ingredient.
Objectives: In this study, the phytochemical and growth traits in hairy and normal roots of Fenugreek in response to gamma irradiation were evaluated.
Method: In this study, gamma irradiation was applied to Iranian Fenugreek seeds in five doses (0, 100, 200, 300 and 400 Gy), and then the irradiation effects in root hair culture conditions in a completely randomized design (CRD) with three replications were evaluated. In order to induce hairy roots in fenugreek, ATCC15834 strain of Agrobacterium rhizogenesis was used.
Results: The results showed that the different irradiation doses had a significant effect on all traits in normal and hairy roots. The comparison of mean of data showed that the highest values of traits were related to 100 Gy and the lowest values of traits related to irradiation of seeds with 400 Gy doses. The trigonelline content was significantly higher in hairy roots than normal roots, so that the amount of trigonelline of hairy roots at different treatments including 0, 100, 200, 300 and 400 Gy were 2.46, 2.67, 2.66, 2.44 and 2.64 times more than normal roots, respectively.
Conclusion: The results indicated that the cell proliferation, growth and amount of trigonelline were increased due to the stimulating effect of low doses of gamma irradiations.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
A Comparative Study on the Effect of Artemisia and Clotrimazole Vaginal Cream on Vaginal Candida Infection on Non-Pregnant Women in Fertile Age in Mashhad in 2016-2017: A Triple Blind Clinical Trial
170
182
FA
S
Ebrahimzadeh Zgemi
PhD student in Reproductive Health, Faculty member of midwifery, Department of Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
N
Golmakani
Assistant professor of Midwifery, Faculty Member of Mashhad University of Medical Sciences, Department of midwifery, Mashhad, Iran
MJ
Asili
Assistant professor of Pharmacy, Faculty member of Mashhad University of Medical Sciences, Department of Pharmacy, Mashhad, Iran
A
Naseri
Assistant professor of Parasitology & Mycology, Faculty member of Mashhad University of Medical Sciences, Department of Parasitology & Mycology, Mashhad, Iran
Z
Mohebbi Dehnavi
Master of Midwifery, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
Z
Kamali
Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
A
Saber Mohammad
Master of Midwifery, Department of Midwifery, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
Background: About 75% of women experience at least one vulvovaginal candidiasis during their life. Clotrimazole is an antifungal drug that has side effects along with its therapeutic properties. For this reason, a large percentage of women tend to use natural herbal treatments. Artemisia is an anti-fungal activity.
Objective: The aim of this study was to compare the effect of Artemisia vulgaris and Clotrimazole on vaginal candida infection on non pregnant women in fertility ages.
Methods: This study is a triple blind clinical trial performed on 72 non-pregnant women in Mashhad in 2016-2017 years. The research units were divided into two groups (receiving Artemisia Vaginal Cream and receiving Clotrimazole Vaginal Cream). After confirmation of candidacy and having consent for participation, by random allocation and treated for seven nights. After the treatment, the data was analyzed using SPSS software (version 24).
Results: After treatment, the score for candidate vaginal symptoms was not significant in Artemisia and Clotrimazole group based on Mann-Whitney test (P = 0.518). The Wilcoxon test showed a significant reduction in the symptoms of vaginal candida infection before and after treatment in both groups of Artemisia (P <0.001) and clotrimazole (P <0.001).
Conclusion: Due to the similar effects of Artemisia and Cholitrimazole, Artemisia can be used as an alternative treatment for vaginal candidiasis due to less side effects.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
Effect of the Adiantum capillus-veneris Extract on Immunohistochemical Expression of Lung Heat-Shock Proteins in Rats Exposed to Hypoxia
183
191
FA
M
Yadegari
PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran, Iran
Sh
Mirdar
Professor, PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences,University of Mazandaran, Mazandaran, Iran
GhR
Hamidian
Assistant Professor, PhD of Histological, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
H
Berenjeian Tabrizi
Assistant Professor, Department of Physical Education and Sport Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran
Background: Despite the traditional use of the Adiantum capillus-veneris plant, there is little evidence of its clinical effects.
Objective: The purpose of the present study was to investigate the effect of the Adiantum capillus-veneris extract on Immunohistochemical expression of Lung heat-Shock Proteins in rats exposed to hypoxia.
Methods: Twenty-four male Wistar rats (control: 8, training-hypoxia: 8, training-hypoxia-supplement: 8) without clinically evident disease were used. The rats were exposed to hypoxia environment for 3 week following 6 weeks interval training. Tweleve of the experimental samples were taken 500 ml Adiantum capillus-veneris extract per body weight (kg) in during exposure to hypoxia environment. Finally lung tissue was removed for immunohistochemistry tests of HSP70 and HSP90. To analyze of data, ANOVA test was used (α≤0.05).
Results: Expression of HSP70 and HSP90 increased significantly in hypoxia group comparison with the control group (P≤0.05). Expression of HSP70 and HSP90 protein decreased significantly in the Supplement hypoxia group comparison with the hypoxia group (P≤0.05).
Conclusion: Reduction effects of Adiantum capillus-veneris extract on expression of the parenchyma lung heat- shock protein in hypoxia conditions was observed that probably indicate decreased oxidative stress in the lung.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
Biochemical and Histopathological Evidence on the Beneficial Effects of Essential Oil of Pistacia atlantica Oleoresin in Acetic Acid-induced Colitis
192
201
OTHER
GhR
Bahrami
Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Sh
Sotoudehkia
Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
L
Hosseinzadeh
Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
MH
Farzaei
Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Y
Shokoohinia
Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Background: Pistacia atlantica subsp. kurdica is an endemic plant of Iran which belongs to Anacardiaceae family. This plant has been proposed as an efficacious remedy for gastrointestinal diseases such as inflammatory bowel disease, colitis, and peptic ulcer.
Objective: In this study we decided to evaluate the efficacy and pharmacological mechanisms involved in anti-colitis effect of essential oil of Pistacia atlantica in Wistar rats.
Method: Sixty Wistar rats were selected for this study and were categorized to 6 groups. Experimental colitis was induced with 3% acetic acid solution. Animals of treatment groups received different daily doses of the essential oil (25, 50, and 100 mg/Kg, orally) and.Sulphasalazine (as the standard drug), for 7 days. At the end of the study, the rats were sacrificed and the colon was removed and assessed for macroscopic and microscopic changes. Also, in order to identify the mechanisms involved in anti-colitis effect of this natural drug, the level of cyclooxygenase (COX)-2 were evaluated.
Results: The essential oil of Pistacia atlantica gum significantly reduced macroscopic and microscopic scores of colitis compared with control group (P <0.01). The essential oil with the dose of 100 mg/kg showed the highest anti-colitis effect. The oil of P. atlantica remarkably suppressed the level of COX-2 in colon tissue (P <0.05).
Conclusion: This research has proved the protective effect of oral administration of essential oil of P. atlantica gum on ulcerative colitis in rats. This natural drug performs anti-colitis potential through inhibiting the pro-inflammatory cytokines.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
The Effect of Aromatherapy with Essential Rose Oils on Blood Pressure in Hypertensive Patients
202
214
FA
S
Mohamadinasab
School of Nursing and Midwifery, Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
A
Ravari
School of Nursing and Midwifery, Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
T
Mirzaei
2- Associate professor, Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
AR
Sayadi
5- Assistant professor, Department of Psychiatric Nursing and Mental Health, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Background: Hypertension is a prevalent health problem worldwide. Complementary medicine is commonly used in the treatment of hypertension and Aromatherapy is one of the complementary therapies.
Objective: The present study was conducted to investigate effects of aromatherapy using essential oils of damask rose on hypertension.
Method: This clinical trial was conducted on 62 hypertension patients, who were randomly assigned to two intervention and control groups. In the intervention group, patients were treated with aromatherapy twice a day for two weeks, each lasting 2 minutes, by inhaling three drops of essential oils of damask rose instill on a piece of cotton. In the control group, placebo was used. Blood pressure of the patients was measured on days 2, 5, 9, 14, and 16. The obtained data were analyzed using statistical independent t-test and repeated measure analysis of variance at P < 0.05.
Results: Both groups were homogenous in terms of demographic specifications. The results showed a statistically significant decrease in systolic blood pressure between the intervention and control groups. Aromatherapy in the intervention group resulted in a statistically significant decrease in diastolic blood pressure, only on day 12. Moreover, on the fifth to the twelfth days, the effect of aromatherapy on pulse decrease in intervention group was more evident than the control group.
Conclusion: Based on the obtained results, essential oils of damask rose can be used as an effective supplementary treatment of hypertension.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
The simultaneous effects of green coffee and combine exercise training on body composition and glucose homeostasis in obese and overweight women
215
227
FA
Nafise
Karimnezhad
Rasht Branch,Islamic Azad University
Marjan
Mahdavi Roshan
Guilan University of Medical Sciences
Fatemeh
Izaddost
Rasht Branch,Islamic Azad University
Ramin
Shabani
Rasht Branch,Islamic Azad University
Background: Obesity and overweight are widely expending in worldwide and containing a wide range of diseases, such as glucose homeostasis disorders. Green coffee and exercise are as Suitable treatment options for this condition.
Objective: The aim was to evaluate the simultaneous effects of green coffee and combine training on body composition and glucose homeostasis in obese and overweight women.
Methods: 26 overweight and obese women randomly divided into three green coffee, combined training and green coffee - combined training groups. Green coffee powder was taken daily as two 125 mg per day before lunch and dinner. Combine training was contain of six weeks, four session per week of progressive endurance- strength training. Insulin and fast blood glucose levels were taken using fasting blood 24 hour before and 48 hour after six weeks period and also, body composition variables were measured before and after period.
Results: Weight, body mass index (BMI), waist circumference, hip circumference, waist to hip ratio (WHR), subcutaneous fat amounts, insulin and HOMA levels were significantly decrease in all three groups that the reduction for all variables except waist circumference, WHR, insulin and HOMA were higher in green coffee- combine training group than two other groups (p<0/05). Blood glucose changes was not significant in any groups (p>0/05).
Conclusion: Results indicated that maybe simultaneous usage of green coffee and combine training have synergistic effects on improving body composition.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
Phytochemical and Morphological Responses of Atropa (Atropa belladonna L.) to PGPR under Greenhouse Conditions
228
240
FA
M
Ineloffer
PhD Student of Crop Physiology, Faculty of Agriculture, Shahroud University of Technology, Shahroud, Iran
M
Heidari
Department of Agronomy, Shahrood University of Technology, Shahrood, Iran
H
Naghdi Badi
Medicinal Plants Research Centre, Institute of Medicinal Plants, ACECR, Karaj, Iran
SM
Tolyat Abulhassani
Iranian Biological Resource Center (IBRC), ACECR, Tehran, Iran
H
Makarian
Department of Agronomy, Shahrood University of Technology, Shahrood, Iran
MR
Ameryan
Department of Agronomy, Shahrood University of Technology, Shahrood, Iran
Background: Atropine and scopolamine are important alkaloids that are widely used in the pharmaceutical industry.
Objective: Determination of the effects of PGPR (Plant growth-promoting rhizobacteria) on phytochemical and morpho-physiological traits of Atropa belladonna L. under greenhouse conditions.
Method: This study was done as a factorial experiment based on a randomized complete block design with 3 replications. PGPR in four levels including control or no inoculation, Pseudomonas, Azotobacter, Pseudomonas + Azotobacter and Thiobacillus + Sulfur as the first factor, and also chemical fertilizer at three levels including no fertilizer, 50% recommended fertilizer and 100% recommended fertilizer as second factor were used.
Results: The PGPR and chemical fertilizer and their interactions had significant effect
(P ≤ 0.01) on phytochemical and morpho-physiological traits. The highest values of root volume, root diameter and root dry weight were obtained from treatment of Azotobacter with 50% recommended fertilizer. The highest atropine and scopolamine levels of leaf (19.58 and 7.77 mg/g, respectively) were observed in no bacteria inoculation with 50% chemical fertilizer. The highest root atropine content was 7.69 mg/g which related to treatment of Thiobacillus + sulfur with 100% recommended fertilizer. The highest content of root scopolamine (5.69 mg/g) was observed in treatment of no bacteria inoculation with 50% recommended fertilizer.
Conclusion: Generally, the results showed that PGPRs (plant growth-promoting rhizobacteria) improved the quantitative and qualitative performance of A. belladonna.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
Protective Effect of the Ethanol Extract of Pomegranate Mesocarp on Isolated Rat Heart Following Ischemia and Reperfusion
241
254
OTHER
K
Rahimi
Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
HR
Kazerani
Department of Physiology, The School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
Background: Ischemic heart disease is the main cause of mortality worldwide.
Objective: The aim of this study was to investigate the effect of intragastric administration of pomegranate fleshy mesocarp (membrane) extract on isolated rat heart following myocardial ischemia and reperfusion.
Methods: Wistar rat’s hearts were removed under deep anesthesia and were studied using Langendorff’s apparatus. During the first stage of the study, isolated hearts in groups of 3 received different concentrations (0.5-0.00001%) of the extract dissolved in Krebs solution. The control group received pure Krebs solution. During the second stage of the study, the control and the test rats, in groups of 10, received distilled water or the ethanol extract of pomegranate juice (200 mg/kg), respectively, daily for 3 weeks. At the end of the experimental period, the hearts of the animals were studied. After 30 min stabilization, all hearts experienced 30 min global ischemia followed by 120 min reperfusion.
Results: Supplementation of pomegranate membrane extract to perfusion solution of isolated hearts suppressed cardiac mechanical activity and increased coronary perfusion pressure. Intragastric administration of the extract caused a significant increase in heart rate and ventricular contractile force. In addition, coronary perfusion pressure increased, and the infarct size significantly decreased compared to the control group.
Conclusion: Direct administration of the extract to isolated hearts results in cardiac depression. However, intragastric administration of the extract causes strong cardioprotective effects against ischemia and reperfusion induced injury in isolated rat hearts.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
The Effects of Portulaca Supplementation on Antioxidant Biomarkers and Oxidative Stress in non-Active Girls
255
263
FA
B
Ghorbanian
Associate Professor of Exercise Physiology, Department of Sport Sciences, Faculty of Education and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran
Y
Saberi
Ph.D. student of Exercise Physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran
K
Azali Alamdari
Associate Professor of Exercise Physiology, Department of Sport Sciences, Faculty of Education and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran
F
Shokrollahi
Master of Sport Physiology, Shahid Madani University, Tabriz, Iran
H
Mohammadi
Master of Sport Physiology, Shahid Madani University, Tabriz, Iran
Background: Oxidative stress results from imbalance in the body's redox position, which results in tissue damage due to increased intracellular radicals. Antioxidants prevent the oxidation of fatty acids and prevent foam cells and atherosclerotic plaque. Portulaca, which is one of the supplements, is considered as an antioxidant-rich plant.
Objective: The purpose of this study was to evaluate the effect of eight weeks of Portulaca supplementation on antioxidant enzymes and oxidative stress in non-active girls.
Methods: This quasi-experimental study was conducted on non-active girls (overweight and obese) with an age range of 20-30 years in Azarbaijan Shahid Madani University. 20 subjects were qualified and randomly divided into two control (n = 10) and complement (n = 10) groups. Subjects of supplemented group received 1200 portulaca mg per day for eight weeks. Data were analyzed by t-test using by SPSS20 software. Statistical significance criterion was set as P<0.05.
Results: The results showed that serum levels of superoxide dismutase (SOD), glutathione peroxidase(GPX) and total antioxidant capacity (TAC) were significantly increased in the supplemented group (P<0.05), while the amount of malondialdehyde (MAD) decreased, this decline was not statistically significant (P> 0.05).
Conclusion: Portulaca supplements are likely to be effective in improving cardiovascular health and preventing cardiovascular disease and strengthening the antioxidant system in overweight and obese people, and destroys lipid peroxidation that produces ROS.
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
18
72
2019
11
1
Study of the Antimicrobial Effects of Aqueous Extract of Olea europaea, Solanum nigrum, Artemisia sieberi, Teucrium polium, Glycyrrhiza glabra on some Food-borne Pathogenic Bacteria
264
273
FA
N
Shariatifar
Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
M
Pirali-Hamedani
School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
M
Moazzen
Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
M
Ahmadloo
Department of Public Health, School of public Health, Qazvin University of Medical Sciences, Qazvin, Iran
D
Yazdani
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
Background: The aqueous extract of some plants has an antibacterial effect on pathogenic bacteria for humans.
Objective: This study designed to investigate the antimicrobial activity of aqueous extract of some plants on some food-borne pathogenic bacteria in a laboratory setting has done.
Method: In an experimental study, plants collected from of Tehran city and aqueous extract of them, extracted. To determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) with two ways of visual and turbidity (OD), serially different concentrations (1.25-80 mg/ml) on different cultures was prepared. Disc diffusion (DD) test in concentrations of 10, 20 and 40 mg/ml to determine the average diameter of inhibition for some bactria, done.
Results: The results showed that the inhibitory and fungicidal aqueous extract of Solanum americanum on various bacteria was more than any other aqueous extracts (Staphylococcus aureus MIC = 10 mg/ml) and also Staphylococcus aureus and Salmonella typhimurium were the most sensitive and most resistant bacteria to aqueous extract, respectively.
Conclusion: According to the results, we can be hopeful the extract of Solanum americanum in the treatment of pathogenic bacteria such as S. aureus, can be help and it can used in the food industry as a food protection. Recommended by extracting the active ingredients of the extract of this plant and other plants, more research done on the composition of extract.