Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
16
64
2017
12
1
Supercritical Carbon Dioxie; An Efficient Solvent for Herbal Extraction
1
11
FA
Mohsen Dashtianeh
Dashtianeh
University of Tehran
mdashtianeh@yahoo.com
N
Alireza
Vatanara
Tehran University of Medical Sciences
vatanara@tums.ac.ir
Y
Shamsali
Rezazadeh
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
shrezazadeh@yahoo.com
N
0000-0001-6255-9190
Supercritical fluid extraction (SFE) is an alternative to liquid extraction using solvents. Supercritical fluids can have solvating powers similar to organic solvents, but with higher diffusivities, lower viscosity, and lower surface tension. Carbon dioxide is the most commonly used supercritical fluid owing to its nontoxic, nonflammable, inexpensive, environmental friendly properties and mild critical conditions (Tc = 31.1 ̊ C and Pc = 73.8 bar). Due to the low heat of process and the relatively unreactive solvent used in the extraction, the fragrant compounds derived often closely resemble the original characteristics of the raw material. Like solvent extraction, extracts a wide range of compounds and leaves the aromatics unaltered by heat, rendering an essence more faithful to the original. In this review, some aspects of this etraction methods have been discussed.
Supercritical etraction, carbon dioxide, Herbal, Essential oils
http://jmp.ir/article-1-1895-en.html
http://jmp.ir/article-1-1895-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
16
64
2017
12
1
Therapeutic Applications of Turmeric and Its Principle Constituent Curcumin in Wound Healing and Skin Regeneration from the Perspective of Conventional Medicine and Iranian Traditional Medicine (ITM)
12
21
FA
zeinab
ghorbani
School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
zeynabghorbani90@yahoo.com
N
Ebrahim
Khadem
Department of of Iranian Traditional Medicine, Faculty of Iranian Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
ekhadem@tums.ac.ir
Y
In Iranian traditional medicine, turmeric is known as Auruk-e-Sufr. This spice is obtained from the root of Curcuma longa L which is a member of ginger family. The present study aimed at introducing turmeric and its active constituent Curcumin, and investigating the effectiveness of its therapeutic applications especially in dermal wound healing process based on traditional and conventional medicine resources. In the view of traditional medicine, turmeric has antibacterial effects and was used to strengthen the eyes, alleviate liver obstruction and jaundice and improve edema. In modern medicine, the most important reason of using this herb to prevent or slow the progression of cardiovascular disease, diabetes, pulmonary and autoimmune diseases, as well as inflammatory bowel disease is attributed to its antioxidant and anti-inflammatory effects. Skin regeneration and wound healing is a complex process which includes many cells as well as various processes such as proliferation, cell migration, matrix synthesis and contraction that ultimately leads to recovery of cellular structures and tissue layers. There are many recommendations in traditional medicine that suggest the use of turmeric as an antiseptic therapeutic agent is beneficial in treating the skin injuries and healing of wounds, as well as improving rash, and scabies. Based on the results of the studies reviewed in this paper, due to anti-inflammatory, antimicrobial, antioxidant and angiogenesis activities of curcumin and turmeric, they can accelerate wound healing and improve scars regardless of the type of the wound or the route of the administration of the agent. Also, one of the main effects of this plant on accelerating wound healing is due to its ability to regulation TGF-β1 signaling pathway.
Curcumin, Conventional Medicine, Iranian traditional medicine, Turmeric, Wound Healing
http://jmp.ir/article-1-1442-en.html
http://jmp.ir/article-1-1442-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
16
64
2017
12
1
Quantitative Changes of Trigonelline Metabolite in Fenugreek (Trigonella foenum- graecum L.) Sprouts under Chitosan and Water Stress Induction
22
32
FA
P
Ahadi
Department of Horticulture Science, Karaj branch, Islamic Azad University, Karaj, Iran
p.ahadi@yahoo.com
N
HA
Naghdi Badi
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
naghdibadi@yahoo.com
N
0000-0001-7070-8467
MR
Labbafi
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
mohammad1700@yahoo.com
Y
0000-0002-2684-8080
Background: Application of bio-stimulants is one of solutions to quantitative and qualitative changes in metabolites of medicinal plants sprouts.
Objective: The aim of this study is to investigate the effect of chitosan bio-stimulation on trigonelline content of sprout under water stress.
Methods: This study was conducted in three separate factorial experiments (three times of 4, 8 and 12 days after planting) based on completely randomized design with 15 treatment in 3 replications. The treatments were chitosan in five levels (0, 0.05%, 0.1%, 0.2% and 0.4%) and water stress in 3 levels (control without stress treatment, -0.2 and 0.4 Mpa).
Results: The result of variance analysis showed that chitosan, under stress and interaction effect of chitosan and water stress had significant effect on trigonelline content of 4, 8 and 12-day sprout. The trigonelline content decreased during the experiment in a way that the highest content of that was observed at the first days of seed germination.
Conclusion: By induction of water stress and application of chitosan with optimum amount (to 0.2%) decrease in trigonelline content attained to the lowest trend during the experiment.
Trigonella foenum- graecum L., Bio-stimulant, Environmental stress, Modeling, Sprout
http://jmp.ir/article-1-1711-en.html
http://jmp.ir/article-1-1711-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
16
64
2017
12
1
Ethnobotanical Study (Identification, Medical Properties and How to Use) of some Medicinal Plants of Behbahan city of Khuzestan Province, Iran
33
49
FA
Damoun
Razmjoue
Behbahan Khatam Alanbia University of Technology, Behbahan, Iran
d.razmjoue@gmail.com
Y
Zahra
Zarei
Behbahan Khatam Alanbia University of Technology, Behbahan, Iran
zahra.zarei1368@gmail.com
N
Raham
armand
Behbahan Khatam Alanbia University of Technology, Behbahan, Iran
N
Background: The ethnobotanical science to study how the people of a race, culture or specific area use the native plants of that region. Since the methods and the indications of medicinal plants in the different regions are various.
Objective: The present study was conducted with the purpose of introducing the traditional application of medicinal plants of Behbahan City for curing the diseases.
Methods: For this purpose, after gathering the native plants of region simultaneously, the local name, medicinal properties, How to use and the other information related to the species were gathered.
Results: In this study, 60 plant species belong to 23 families were identified. The Lamiaceae, Apiaceae, Asteraceae, Poaceae and Solanaceae families respectively with having 7, 7, 6, 5 and 4 species had the most number of plants species. By examining the types of plants used as Sodden consumption was found that most (45%) and then the tail and Crude (30 percent).
Conclusion: Existence of 60 medicinal plant species in Behbahan City shows that the city is reach in terms of having access to medicinal plants; and this matter can provide suitable field for better usage of medicinal plants of this city for producing the productions with more effectiveness and less disadvantages.
Apiaceae, Behbahan, Ethnobotanical, Lamiaceae, Medicinal plants
http://jmp.ir/article-1-1384-en.html
http://jmp.ir/article-1-1384-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
16
64
2017
12
1
The Study of Relative Expression of Key Genes of Thymol Biosynthesis Pathway in Thymus vulgaris cv. ‘Varico 3’ under Cold Stress Using Real-Time PCR
50
58
FA
Sh
Habibi
Department of Horticultural Science, Faculty of Agriculture, Lorestan University, Lorestan, Iran
N
A
Qaderi
Medicinal Plants Research center, Institute of Medicinal Plants, ACECR, Karaj, Iran
N
0000-0001-6525-9265
F
Fatehi
Faculty of Agriculture, Payame Noor University (PNU), Tehran, Iran
Y
Background: Thyme (Thymus vulgaris L.) is a valuable medicinal plant which has many secondary metabolites such as thymol and carvacrol.
Objective: This study was done to evaluation of cold stress effect on gene expression in thymol biosynthesis pathway including DXR، HMGR and TPS1.
Methods: The effect of cold stress in the time period of 0, 3, 12, 24 and 48 hours on gene expression in thymol biosynthesis pathway including DXR, HMGR and TPS1 was evaluated by RT-PCR. This study was done on base of complete randomized design (CRD) in Institute of Medicinal Plants, ACECR, Karaj, Iran.
Results: Results showed that the cold stress had significantly effect on expression of studied genes. The highest expression of HMGR gene was observed within 3 hours after cold treatment (1.57 times more than control treatment). The expression of DXR and TPS1 genes were reduced in different periods of cold stress.
Conclusion: In general, the genes expression of thymol and carvacrol biosynthesis pathway including DXR, HMGR and TPS1 were significantly changed by cold stress.
Thymus vulgaris L., Cold stress, Gene expression, Thymol
http://jmp.ir/article-1-1975-en.html
http://jmp.ir/article-1-1975-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
16
64
2017
12
1
Long Term Effect of High Intensity Interval Training and Flaxseed Oil Supplementation on the Expression of Genes Involved in Reverse Cholesterol Transport in Male Rats
59
75
FA
S
Rahmati-Ahmadabad
Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran
N
H
Shirvani
Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
Y
V
Sobhani
Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
N
Background: The potential effect of exercise training with supplementation in improving fat metabolism and complications of lipid disorders is an interesting subject.
Objective: The aim of this study was to investigate the effect of high intensity interval training and flax seed oil supplementation on liver and intestine ABCA1, SR-BI, ABCG1, LXR gene expression, as well as the concentration of HDL, LCAT and plasma lipids in male rats.
Methods: Forty adult Wistar rats were randomly divided into eight groups (n=5) including control-saline, training-saline, control-flaxseed oil (With 3 doses), and training-flaxseed oil. The training groups were given high-intensity interval training (10 weeks, five sessions in week) on a rodent treadmill at 90–95% of VO2max and supplement groups also received flaxseed oil with three different doses (10, 20 and 30 mg/kg per cage). Then rats were sacrificed and samples were collected.
Results: The results showed that the training created a significant increase (P<0.01) in the expression of liver ABCA1 and ABCG1genes, intestine ABCA1, LXR and SRBI genes, as well as the plasma HDL and LCAT concentration. Supplements caused a significant decrease (P<0.001) in expression of liver ABCA1 genes. There was a significant and positive correlation between liver ABCG1 gene expression with plasma HDL and LCAT, as well as between intestine LXR gene expression with plasma HDL.
Conclusion: Long-term consumption of even unsaturated oils may have adverse effects on the cardiovascular system, but high intensity interval training can bring health benefits by increasing the expression of genes involved in reverse cholesterol transport.
High-Intensity Interval Training, Flaxseed Oil Supplement, Reverse Cholesterol Transport, ABCA1, ABCG1, LXR
http://jmp.ir/article-1-1976-en.html
http://jmp.ir/article-1-1976-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
16
64
2017
12
1
The Effect of a Combined Herbal Ointment (Pepper, Rosemary, Peppermint) on Low back Pain after Coronary Angiography
76
82
FA
Rezvan
Ghafarzadegan
Department of Nursing, Khomein Faculty of Medical Sciences, Arak University of Medical Sciences, Arak, Iran
rghafarzadegan@gmail.com
N
Masoomeh
Noruzi
Department of Nursing, Khomein Faculty of Medical Sciences, Arak University of Medical Sciences, Arak, Iran
norouzi masoomeh @yahoo.com
N
Masoomeh
Mousavi
Adult Health Department, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
ms_mousavi2012@yahoo.com
Y
Zeinab
Alizadeh
Department of Nursing, Arak University of Medical Sciences, Arak, Iran
harurani m @yahoo.com
N
mehdi
harurani
Department of Nursing, Arak University of Medical Sciences, Arak, Iran
reza.ghafary@yahoo.com
N
Reza
Ghafarzadegan
Medicinal Plants Research Centre, Institute of Medicinal Plants, ACECR, Karaj, Iran
javahery j @gmail.com
N
0000-0001-5351-2913
javad
javaheri
Khomein University of Medical Sciences, Khomein, Iran
N
Background: Angiography is one of the most important diagnostic procedures of heart patients is that despite many advantages in the detection of coronary artery disease , has caused many problems for patients. To prevent these complications, the patient is recommended bed rest. Followed this situation, back pain occurred and low back pain is common among these patients.
Objective: This study aims to assess the effect of topical herbal ointment on back pain in angiography patients.
Methods: This study was a two groups randomized clinical trial, in which patients underwent coronary angiography were selected with available sampling and randomly divided into two groups (taking herbal ointment) and control (placebo) and on angiography day and one day later treated with herbal ointment (4 times a day) and before taking the ointment, and at the end of the second day, pain was measured by VAS scale.
Results: In this study assessed 80 patients that received angiography. The mean pain score in the test group prior to the intervention was 4/05 with a standard deviation 2/24 and after intervention was 2/47 with standard deviation 1/66. pain score in the control group prior to the intervention was 3/52 with a standard deviation 1/93 and after intervention was 3/45 with standard deviation 1/82.
Conclusion: With regard the results of this study we can conclude that this herbal ointment (pepper, rosemary, peppermint) can reduce low back pain in patients after angiography and we can use this ointment to increase patient comfort although more research with more samples is needed in this area to achieve a certain result.
Herbal ointment, Low back pain
http://jmp.ir/article-1-1752-en.html
http://jmp.ir/article-1-1752-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
16
64
2017
12
1
Cytotoxic Effects of Allium affine Ledeb Butanolic Fraction on Breast and Ovary Cancer Cell Lines
83
90
FA
Maliheh
Kazemi
School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
malihekazemi70@yahoo.com
N
Behzad
Zolfaghari
Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
behzadz@gmail.com
N
Mahammad
Keyvanlo Shahrestanaki
Department of clinical Biochemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
mkshkeyvan@gmail.com
N
Masoud
Sadeghi Dinani
Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
m_sadeghi@pharm.mui.ac.ir
Y
Background: Among the secondary metabolites isolated from Allium species, steroidal saponins are more important for their cytotoxic activities on a variety of cancer cell lines. Current study has investigated the cytotoxic activity of saponin-riched butanolic fraction of Allium affine, an important edible Allium species of Iran.
Objective: This study was conducted to evaluate cytotoxic activity of saponin-riched fraction of Allium affine Ledeb on breast and ovarian cancer cell lines.
Methods: Bulbs of the plant were extracted respectively by hexane, chloroform, chloroform-methanol (9-1) and methanol in a stepwise method with increasing solvent polarity. The methanol extract was then partitioned between water and butanol and the final dried butanolic fraction was used for further cytotoxicity assay. MCF-7, MDA-MB231 and OVCAR-3 cell lines were tested for cytotoxic activity, using different concentrations of butanolic fraction (0.1-200 µg/ml) by MTT assay. After the incubation time (48 h), the percentage of the viable cells was determined by ELISA reader instrument in 570 nm.
Results: All of the cell lines tested in this investigation exhibited a dose-dependent decrease in succinate dehydrogenase activity against the control and significant dose-dependent inhibition of the growth in all concentrations and cell lines were observed (P<0.01). The most cytotoxic activity was observed for OVCAR-3 cell line (IC50= 7.13±0.94 µg/ml).
Conclusion: The butanolic fraction of A. affine exhibited a significant cytotoxic activity on investigated cell lines, especially OVCAR-3, which is in agreement with other studies conducted on different Allium species. According to the results, it seems that the butanolic fraction of this plant contains cytotoxic components, especially steroidal saponins, and the phytochemical study of the constituents is suggested.
Allium affine, Breast Cancer, Cytotoxicity, Ovarian Cancer, Steroidal Saponin
http://jmp.ir/article-1-1660-en.html
http://jmp.ir/article-1-1660-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
16
64
2017
12
1
Phytochemical Response of Sweet Basil (Ocimum basilicum) to Application of Methanol Biostimulant and Iron Nano-chelate
91
106
FA
HA
Naghdi Badi
Medicinal Plants Research Centre, Institute of Medicinal Plants, ACECR, Karaj, Iran
Naghdibadi@gmail.com
N
0000-0001-7070-8467
SM
Tolyat Abulhassani
Medicinal Plants Research Centre, Institute of Medicinal Plants, ACECR, Karaj, Iran
M_a_tolyat@yahoo.com
N
M
Nazari
Department of Horticulture, Science and Research Branch, Islamic Azad University (IAU), Tehran, Iran
Md.Nazari66@gmail.com
N
A
Mehrafarin
Medicinal Plants Research Centre, Institute of Medicinal Plants, ACECR, Karaj, Iran
A.Mehrafarin@gmail.com
Y
0000-0003-0790-9535
Background: Ocimum basilicum L. belongs to the Lamiaceae family. Its essential oil is anti-bacterial and anti-fungi it is used an appetizer and counterfeit. Methanol spraying as a source of providing carbon for C3 plant, can increase the plant yield, and its rate of ripping it can decrease the effect of water stress.
Objective: The present study was conducted to investigate the effect of foliar application of methanol and nano-iron chelated fertilizer on phytochemical and morph physiological characteristics of basil.
Methods: In this research, the factorial experiment in a randomized complete blocks design with 20 treatments and 3 replications was carried out. The treatments of this experiment were consisted of five levels of Methanol (0, 10, 20, 30, and 40 %) and four levels of Nano-iron chelate (0, 0.5, 1, 1.5 g/L) fertilizer.
Results: The study showed that spraying methanol with 20% volume along with 1 g/L of nano-iron chelated increased dry matter and oil yield and also increased methyl-cahvicol and Caryophyllene in Basil. Results showed that activity of Glutathione peroxidase enzyme was increased with increasing the percentage of bio simulative methanol, while activity of polyphenol oxidase was decreased.
Conclusion: Nano-iron chelated increased the activity of these enzymes. It can be concluded that higher densities of bio-simulative methanol and Nano-iron chelated increased essential oil, methyl-cahvicol and some other affective enzymes which decrease induced environmental stresses. Although, higher densities of them would decrease biosynthesis of neral and neryl formate.
Ocimum basilicum L., Foliar applied Methanol, Glutathione peroxidase, Methyl-cahvicol, Nano-iron chelated, Polyphenol oxidase
http://jmp.ir/article-1-1682-en.html
http://jmp.ir/article-1-1682-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
16
64
2017
12
1
Characterization of Effective Parameters on the Synthesized Gold Nanoparticles and Investigating their Antimicrobial Activities Using Aqueous Extract of Hibiscus sabdariffa L.
107
122
FA
M
Mehrzadeh
University of Sistanand & Baluchestan, Zahedan
marzie.mehrzade@yahoo. com
Y
J
Valizadeh
University of Sistanand & Baluchestan, Zahedan
walisade@hamoon.usb.ac.ir
N
A
Ghasemi
University of Sistanand & Baluchestan, Zahedan
qasemi@science.usb.ac.ir
N
Background: During the last decade research have been focussed on developing simple, clean, non-toxic, cost effective and ecofriendly protocols for synthesis of nanoparticles.
Objective: The current study aim to characterization and biosynthesis of gold nano particles (Au NPs) using calyx aqueous extract of Hibiscus sabdariffa L. and study of their antimicrobial activity.
Methods: Gold nano particles (AuNPs) were biosynthesized by using HAuCl4.3H2O and the calyx aqueous extract of Hibiscus sabdariffa L. In order to gain the best AuNPs with a uniform shape and size, parameters affecting on synthesis such as: volume of plant extract, pH of the reaction, concentration of HAuCl4.3H2O solution, time of reaction were investigated and optimized by UV-Vis spectrophotometry. Moreover, transmission electron microscopy (TEM) and X-ray diffraction (XRD) were used for further characterization of the nanoparticles. Finally, the antibacterial properties of gold nanoparticles were evaluated by disc diffusion method.
Results: The results of transmission electron image identified the formation of spherical nanoparticles with a size range of 5-10nm. A sharp peak with a maximum absorbance of 570nm was observed which is the characteristic wavelength of gold nanoparticles. The highest inhibition were obtained with the gold nanoparticles against Hafnia alvei bacteria.
Conclusion: In this study, the gold nanoparticles synthesized by calyx aqueous extract of
H. sabdariffa L. and they have relatively good antibacterial activity against Gram-negative bacteria.
Hibiscus sabdariffa L., Antibacterial activity, Biosynthesis, Gold Nanoparticles
http://jmp.ir/article-1-1635-en.html
http://jmp.ir/article-1-1635-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
16
64
2017
12
1
Evaluation of Morphophysiological and Phytochmical Traits of Different Ecotypes of Salvia multicaulis Vahl. in Hamedan Province, Iran
123
136
FA
F
Salehi
Horticultural Sceinces Departiment, Agriculture Faculty, Ferdowsi University of Mashhad, Mashhad, Iran
N
H
Arouiee
Horticultural Sceinces Departiment, Agriculture Faculty, Ferdowsi University of Mashhad, Mashhad, Iran
aroiee@ferdowsi.um.ac.ir
Y
HA
Naghdi Badi
Medicinal Plants Research Centre, Institute of Medicinal Plants, ACECR, Karaj, Iran
N
0000-0001-7070-8467
SH
Nemati
Medicinal Plants Research Centre, Institute of Medicinal Plants, ACECR, Karaj, Iran
N
SM
Tolyat Abulhassani
Horticultural Sceinces Departiment, Agriculture Faculty, Ferdowsi University of Mashhad, Mashhad, Iran
N
Background: Salvia multicaulis Vahl. a medicinal plant belonging to the Lamiaceae family, has an extensive application in native and traditional medicine.
Objective: This research was conducted to investigate diversity of morphophysiological traits and content of essential oil, phenol and flavonoid of Salvia multicaulis ecotypes in different districts of Hamedan province, Iran.
Methods: In this study, 11 ecotypes of Salvia multicaulis were collected from different districts of Hamedan Province at the full flowering stage in spring 2016 and were evaluated for their morphophysiological and phytochemical characteristics. The classification of ecotypes was done on the basis of phytochemical and morphophysiological traits by cluster analysis and correlations among quantitative traits was also conducted by Pearson method.
Results: Result showed that the essential oil content had positive significant correlation with plant height, inflorescence length, dry matter of flowering branche and essential oil yield. Also there was a positive significant correlation between essential oil yield with receptacle length, flower fresh and dry matter and plant dry matter. The heighes dry weight of flowering branch and flower was related to ecotypes of Lashkardar and west of Hamedan, respectively. The maximum plant dry weight was belong to Yelfan ecotype. The most essential oil content was related to Lashkardar and west of Hamedan ecotypes. Also, the highest content of phenol and flavonoid related to Vehnan ecotype. According to the cluster analysis, 11 ecotypes were divided into two groups.
Conclusion: The evaluation of morphophysiological and phytochemical traits showed that there was a considerable variation among different ecotypes of Salvia multicaulis in respect of morphophysiological and phytochemical characteristics.
Salvia multicaulis Vahl., Essential oil, Ecotype, Morphophysiological traits, Phenol and flavonoid content
http://jmp.ir/article-1-1981-en.html
http://jmp.ir/article-1-1981-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
16
64
2017
12
1
The Effects of Hydroalcoholic Extract of Raspberry fruit on Pain and Passive Avoidance Memory Following Transient Global Ischemia/Reperfusion in Wistar Rats
137
146
FA
Mohammad Hossein
Mohammadi Mehdiabadihassani
Department of Animal Biology, Faculty of Biological Sciences, Karazmi University, Tehran, Iran
N
Mojtaba
Moradi
Physiology Department, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
N
Esmaeil
Khoshnam
Physiology Department, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
esmaeil.khoshnam1392@gmail.com
N
Shima
Mohammadi
Neuroscience Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
shimamohamadi1365@gmail.com
Y
Background: Brain ischemia is one of the leading causes of death and physical disability worldwide. Flavonoids found in Raspberry fruit (RF) play an important role against oxidative stress injuries in the biological systems.
Objective: The present study was carried out to evaluate the effect of RF on ischemia/reperfusion (I/R)-induced brain injury in rats.
Methods: In the present experimental study, 42 wistar adult male rats weighing 200–250 g were divided into six groups as sham operated (Sh), ischemia/reperfusion (I/R) received normal saline (I+Veh), I/R groups treated with RF extract (I+RF, 50, 100, or 200 mg/kg, IP, respectively). The global cerebral I/R was induced by occluding bilateral common carotid arteries for 30 min, followed by reperfusion. Behavioral test performed with shuttle box and analgesia test performed with tail flick test.
Results: Administration of RF extract 50, 100, or 200 mg/kg doses increased passive avoidance memory significantly (P<0.05). In addition, RF extract delayed the emergence of painful reflux in tail flick test significantly (P<0.05).
Conclusion: Results of this study showed that RF extract possesses protective effects against pain and memory deficits induced by I/R, which may be due to its anti-inflammatory and antioxidant effects.
Cerebral Ischemia/Reperfusion, Memory, Pain, Raspberry Fruit
http://jmp.ir/article-1-1558-en.html
http://jmp.ir/article-1-1558-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
16
64
2017
12
1
Investigation of Different Drying Methods of Peppermint (Mentha piperita) Medical Plant
147
161
FA
M
Mokhtarian
Young Researchers and Elite Club, Roudhen Branch, Islamic Azad University, Roudhen, Iran
mokhtarian.mo@gmail.com
Y
H
Hamedi
Department of Food Safety and Hygiene, Science and Research Branch, Islamic Azad University, Tehran, Iran
alayandeha@gmail.com
N
NA
Jonaidi-Jafari
Health & Nutrition Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
mokhtarian.mo@gmail.com
N
A
Akhondzadeh Basti
Department Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
aakhond@ut.ac.ir
N
Background: Agriculture products, especially medical plants after harvest should be processed by different processes such as removal of foreign bodies, washing and cleaning, drying, packaging and so forth. One of main postharvest stages of medical plant especially peppermint is drying process.
Objective: The aim of this study is design a solar dryer equipped with double pass collector to drying process of peppermint and comparison their results with traditional drying methods (sun and shade).
Methods: In this study drying process of peppermint with different methods of solar drying (by solar dryer designed in this study) and also traditional drying (shade and sun drying) were investigated and compared.
Results: The drying time required for dehydration of peppermint in solar drying method was 150 min, which it was approximately 82% and 55% shorter than to traditional methods of shade and sun. Furthermore, dehydration rate in drying methods of solar drying, sun drying and shade drying were 26.77, 12.48 and 4.48 (kg H2O/kg D.M h), respectively. The results of mathematical modelling indicated that Midli and kucuk (in drying methods of solar and shade) and Aghbashlo et al (in drying method of sun) can be fitted drying curve of this medical plant with high accuracy. Also, solar drying by dryer could be protecting the essential oil of this plant in the best form. The results show that the main components of peppermint essential oil was included: 1,8-Cineole, cis-Sabinene hydrate, Menthone, Menthofuran, iso-Menthone, Menthol and iso-Menthol
Conclusion: Generally, solar drying method of peppermint was recommended as the best method for postharvest processing of this medical plant.
Drying, Monolayer modelling, Peppermint, Postharvest operation
http://jmp.ir/article-1-1677-en.html
http://jmp.ir/article-1-1677-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
16
64
2017
12
1
Effect of the Adiantum capillus Veneris Extract on Bax and Bcl2 Apoptotic Markers of Lung Modulation in Trained Rats and Exposed to Hypoxic Stress
162
171
FA
M
Yadegari
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran, Iran
Y
S
Riahy
Researcher of Research Center of Epidemiology Science and Technology, Medical Sciences Army University, Tehran, Iran
N
Sh
Mirdar
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran, Iran
N
GhR
Hamidian
Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
N
P
Mosadegh zavaragh
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran
N
Background: Apoptosis is a type of programmed cell death that occurs by a series of Intercellular messages under Specific conditions.
Objective: The aim of present study was investigat role of the Adiantum capillus veneris extract on modulation of Bax and Bcl2 Apoptotic markers of lung in trained rats and exposed to hypoxic stress.
Methods: 14 male Wistar rats were sampels of This study, that were Quite healthy and had no disease history (4 weeks old, 72±9 gr weight) that exposed to hypoxic Environment for 3 weeks after 6 weeks high intensity interval training. Half of the samples were taken 500 ml Adiantum capillus veneris extract Per kilogram of body weight in During exposure to hypoxia environment. Finally, lung tissue was extracted for Immunohistochemical Measurements.
Results: Statistical analysis showed that Adiantum capillus veneris extract Consumption for 3 veeks in samples that exposed to hypoxia, Significantly reduced Bax protein Expression of Pulmonary alveolar (P≤0.05). also was observed Adiantum capillus veneris extract Consumption for 3 veeks non Significantly increased Bcl2 protein expression (P> 0.05) and Significantly reduced Bax /Bcl2 Ratio(P≤0.05).
Conclusion: It seems that Adiantum capillus veneris extract, Could possibly modulat Pro-apoptotic and anti-apoptotic proteins expression in pulmonary alveolars that exposed to hypoxic Environment that likely has Considerable effects to Inhibition of lung Pro-apoptotic reactions Due hypoxia.
Adiantum capillus veneris, Bax, Bcl2, High intensity interval training, Hypoxia
http://jmp.ir/article-1-1984-en.html
http://jmp.ir/article-1-1984-en.pdf