Journal of Medicinal Plants
فصلنامه گياهان دارویی
J. Med. Plants
Medical Sciences
http://jmp.ir
1
admin
2717-204X
2717-2058
10.61186/jmp
14
8888
13
en
jalali
1394
6
1
gregorian
2015
9
1
14
55
online
1
fulltext
en
Effects of <i>Aloe vera</i>, <i>Camellia sinensis</i>, <i>Hibiscus sabdariffa</i> and <i>Sophora alopecuroides</i> in Rat Model of Indomethacin-Induced Gastric Ulcer
Effects of <i>Aloe vera</i>, <i>Camellia sinensis</i>, <i>Hibiscus sabdariffa</i> and <i>Sophora alopecuroides</i> in Rat Model of Indomethacin-Induced Gastric Ulcer
فارماكولوژی و سم شناسی
Pharmacology & Toxicology
پژوهشی
Research
<p dir="ltr" style="margin-left: 14.2pt; text-align: justify;"><strong>Background:</strong> Evidences show that <em>Aloe vera </em>(<em>A. vera</em>), <em>Camellia sinensis</em>, <em>Hibiscus sabdariffa</em> and <em>Sophora alopecuroides </em>may prevent gastric ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs).</p>
<p dir="ltr" style="margin-left: 14.2pt; text-align: justify;"><strong>Objective:</strong> To examine the protective potential of these plants against indomethacin-induced gastric ulcer in the rat.</p>
<p dir="ltr" style="margin-left: 14.2pt; text-align: justify;"><strong>Methods:</strong> Saline, <em>A. vera</em> leaf gel powder and 70% alcoholic extracts of the other 3 plants (100, 400, 800 mg/kg) and omeprazole (30 mg/kg) were gavaged to the groups of 10 animals for 4 consecutive days. Gastric ulcers were induced by the onetime gavage of indomethacin (30 mg/kg). On the fifth day, each group was pretreated with physiological saline as control, extract (100, 400 or 800 mg/kg) or omeprazole (30 mg/kg) 30 min before the indomethacin administration. The animals were killed 6 h after the indomethacin administration. The stomachs were removed, opened along the greater curvature and washed in physiological saline. A person unaware of the type of treatment received by the animals examined the stomachs under a 3-fold magnifier. The areas and lengths of hemorrhagic lesions induced by indomethacin were measured using a dial caliper and the sum of measurements for each animal was referred to as the ulcer index.</p>
<p dir="ltr" style="margin-left: 14.2pt; text-align: justify;"><strong>Results:</strong> All doses of the <em>A. vera</em> leaf gel powder and extracts reduced the ulcer index significantly compared to the control group (<em>p</em> < 0.05).</p>
<p dir="ltr" style="margin-left: 14.2pt; text-align: justify;"><strong>Conclusion:</strong> These plants have protective effect against NSAID-induced gastric ulcer in the rat. The <em>A. vera</em> leaf gel seems noticeably more effective than the other 3 plants in this respect.</p>
<div dir="ltr" style="text-align: justify;"></div>
<p dir="ltr" style="margin-left: 14.2pt; text-align: justify;"><strong>Background:</strong> Evidences show that <em>Aloe vera </em>(<em>A. vera</em>), <em>Camellia sinensis</em>, <em>Hibiscus sabdariffa</em> and <em>Sophora alopecuroides </em>may prevent gastric ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs).</p>
<p dir="ltr" style="margin-left: 14.2pt; text-align: justify;"><strong>Objective:</strong> To examine the protective potential of these plants against indomethacin-induced gastric ulcer in the rat.</p>
<p dir="ltr" style="margin-left: 14.2pt; text-align: justify;"><strong>Methods:</strong> Saline, <em>A. vera</em> leaf gel powder and 70% alcoholic extracts of the other 3 plants (100, 400, 800 mg/kg) and omeprazole (30 mg/kg) were gavaged to the groups of 10 animals for 4 consecutive days. Gastric ulcers were induced by the onetime gavage of indomethacin (30 mg/kg). On the fifth day, each group was pretreated with physiological saline as control, extract (100, 400 or 800 mg/kg) or omeprazole (30 mg/kg) 30 min before the indomethacin administration. The animals were killed 6 h after the indomethacin administration. The stomachs were removed, opened along the greater curvature and washed in physiological saline. A person unaware of the type of treatment received by the animals examined the stomachs under a 3-fold magnifier. The areas and lengths of hemorrhagic lesions induced by indomethacin were measured using a dial caliper and the sum of measurements for each animal was referred to as the ulcer index.</p>
<p dir="ltr" style="margin-left: 14.2pt; text-align: justify;"><strong>Results:</strong> All doses of the <em>A. vera</em> leaf gel powder and extracts reduced the ulcer index significantly compared to the control group (<em>p</em> < 0.05).</p>
<p dir="ltr" style="margin-left: 14.2pt; text-align: justify;"><strong>Conclusion:</strong> These plants have protective effect against NSAID-induced gastric ulcer in the rat. The <em>A. vera</em> leaf gel seems noticeably more effective than the other 3 plants in this respect.</p>
Anti-ulcer, Non-steroidal anti-inflammatory drug, Rat
Anti-ulcer, Non-steroidal anti-inflammatory drug, Rat.
58
65
http://jmp.ir/browse.php?a_code=A-10-71-19&slc_lang=en&sid=1
H
Fallah Huseini
Hasan
Fallah Huseini
huseini_fallah@yahoo.com
100319475328460041682
100319475328460041682
No
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
Institute of Medicinal Plants
S
Kianbakht
Saeed
Kianbakht
skianbakht@yahoo.com
100319475328460041683
100319475328460041683
Yes
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
T
Rajabian
Tayebeh
Rajabian
rajabian@shahed.ac.ir
100319475328460041684
100319475328460041684
No
Department of Biology, Faculty of Science, Shahed University, Tehran, Iran.
Department of Biology, Faculty of Science, Shahed University, Tehran, Iran.