Journal of Medicinal Plants

en Effects of Aloe vera, Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides in Rat Model of Indomethacin-Induced Gastric Ulcer Effects of Aloe vera, Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides in Rat Model of Indomethacin-Induced Gastric Ulcer فارماكولوژی و سم شناسی Pharmacology & Toxicology پژوهشی Research Background: Evidences show that Aloe vera (A. vera), Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides may prevent gastric ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs). Objective: To examine the protective potential of these plants against indomethacin-induced gastric ulcer in the rat. Methods: Saline, A. vera leaf gel powder and 70% alcoholic extracts of the other 3 plants (100, 400, 800 mg/kg) and omeprazole (30 mg/kg) were gavaged to the groups of 10 animals for 4 consecutive days. Gastric ulcers were induced by the onetime gavage of indomethacin (30 mg/kg). On the fifth day, each group was pretreated with physiological saline as control, extract (100, 400 or 800 mg/kg) or omeprazole (30 mg/kg) 30 min before the indomethacin administration. The animals were killed 6 h after the indomethacin administration. The stomachs were removed, opened along the greater curvature and washed in physiological saline. A person unaware of the type of treatment received by the animals examined the stomachs under a 3-fold magnifier. The areas and lengths of hemorrhagic lesions induced by indomethacin were measured using a dial caliper and the sum of measurements for each animal was referred to as the ulcer index. Results: All doses of the A. vera leaf gel powder and extracts reduced the ulcer index significantly compared to the control group (p < 0.05). Conclusion: These plants have protective effect against NSAID-induced gastric ulcer in the rat. The A. vera leaf gel seems noticeably more effective than the other 3 plants in this respect. <div dir="ltr" style="text-align: justify;"></div> Background: Evidences show that Aloe vera (A. vera), Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides may prevent gastric ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs). Objective: To examine the protective potential of these plants against indomethacin-induced gastric ulcer in the rat. Methods: Saline, A. vera leaf gel powder and 70% alcoholic extracts of the other 3 plants (100, 400, 800 mg/kg) and omeprazole (30 mg/kg) were gavaged to the groups of 10 animals for 4 consecutive days. Gastric ulcers were induced by the onetime gavage of indomethacin (30 mg/kg). On the fifth day, each group was pretreated with physiological saline as control, extract (100, 400 or 800 mg/kg) or omeprazole (30 mg/kg) 30 min before the indomethacin administration. The animals were killed 6 h after the indomethacin administration. The stomachs were removed, opened along the greater curvature and washed in physiological saline. A person unaware of the type of treatment received by the animals examined the stomachs under a 3-fold magnifier. The areas and lengths of hemorrhagic lesions induced by indomethacin were measured using a dial caliper and the sum of measurements for each animal was referred to as the ulcer index. Results: All doses of the A. vera leaf gel powder and extracts reduced the ulcer index significantly compared to the control group (p < 0.05). Conclusion: These plants have protective effect against NSAID-induced gastric ulcer in the rat. The A. vera leaf gel seems noticeably more effective than the other 3 plants in this respect. Anti-ulcer, Non-steroidal anti-inflammatory drug, Rat Anti-ulcer, Non-steroidal anti-inflammatory drug, Rat. 58 65 http://jmp.ir/browse.php?a_code=A-10-71-19&slc_lang=en&sid=1 H Fallah Huseini Hasan Fallah Huseini huseini_fallah@yahoo.com 100319475328460041682 100319475328460041682 No Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Institute of Medicinal Plants S Kianbakht Saeed Kianbakht skianbakht@yahoo.com 100319475328460041683 100319475328460041683 Yes Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran T Rajabian Tayebeh Rajabian rajabian@shahed.ac.ir 100319475328460041684 100319475328460041684 No Department of Biology, Faculty of Science, Shahed University, Tehran, Iran. Department of Biology, Faculty of Science, Shahed University, Tehran, Iran.