en The Effect of Ethanolic Extract of <i>Salvia officinalis</i> on the Uterine Natural Killer Cells Population at Day 7 of Pregnancy فارماكوگنوزی و فارماسيوتيكس Pharmacognosy & Pharmaceutics پژوهشی Research <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Pregnancy is one of the changer agents for defensive cells, however it is unknown the effect of the ethanolic extract of the <em>Salvia officinalis</em> on the uterine Natural Killer cells population in the pregnant mice that needs to be investigated. <strong>Objective:</strong> The aim of this study was to determine the effect of the ethanolic extract of the <em>Salvia officinalis</em> on the uterine Natural Killer cells population. <strong>Methods:</strong> 10 female mice divided into two groups (control and test group). Mice in the control group mated with fertile male mice and mice in the test group received 100 mg/kg of the ethanolic extract of the <em>Salvia officinalis</em> once a day for 14 days, then mated with the fertile male mice. Mice in each group were examined at day 7 of pregnancy for ovarian hormones and evaluation of uterine Natural Killer cells. <strong>Results:</strong> Uterine Natural Killer cells population significantly decreased in the test group compare to the control group (p<0.05). Ovarian hormone levels (17-&beta; estradiol and progesterone) were significantly increased in the test group comparison with the control group (p<0.05). <strong>Conclusion:</strong> It is concluded that decline in uterine Natural Killer cells population after treatment with the ethanolic extract of the Salvia officinalis could be due to hormonal changes that may be affect the implantation and embryo development.</div> <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Pregnancy is one of the changer agents for defensive cells, however it is unknown the effect of the ethanolic extract of the <em>Salvia officinalis</em> on the uterine Natural Killer cells population in the pregnant mice that needs to be investigated. <strong>Objective:</strong> The aim of this study was to determine the effect of the ethanolic extract of the <em>Salvia officinalis</em> on the uterine Natural Killer cells population. <strong>Methods:</strong> 10 female mice divided into two groups (control and test group). Mice in the control group mated with fertile male mice and mice in the test group received 100 mg/kg of the ethanolic extract of the <em>Salvia officinalis</em> once a day for 14 days, then mated with the fertile male mice. Mice in each group were examined at day 7 of pregnancy for ovarian hormones and evaluation of uterine Natural Killer cells. <strong>Results:</strong> Uterine Natural Killer cells population significantly decreased in the test group compare to the control group (p<0.05). Ovarian hormone levels (17-&beta; estradiol and progesterone) were significantly increased in the test group comparison with the control group (p<0.05). <strong>Conclusion:</strong> It is concluded that decline in uterine Natural Killer cells population after treatment with the ethanolic extract of the Salvia officinalis could be due to hormonal changes that may be affect the implantation and embryo development.</div> ,Salvia officinalis, Ethanolic extract, Pregnancy, Uterine Natural Killer cell Salvia officinalis, Ethanolic extract, Pregnancy, Uterine Natural Killer cell 15 24 http://jmp.ir/browse.php?a_code=A-10-765-1&slc_lang=en&sid=1 N Beigi Boroujeni N Beigi Boroujeni nasim_boroujeni@yahoo.com 100319475328460041753 100319475328460041753 Yes Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran M Beigi Boroujeni M Beigi Boroujeni 100319475328460041754 100319475328460041754 No Department of Biochemistry, Payame Noor University of Tehran, Tehran, Iran Department of Biochemistry, Payame Noor University of Tehran, Tehran, Iran E Rafiei Alavi E Rafiei Alavi 100319475328460041755 100319475328460041755 No Department of Pathology, Lorestan University of Medical Sciences, Khorramabad, Iran Department of Pathology, Lorestan University of Medical Sciences, Khorramabad, Iran A Shafiei A Shafiei 100319475328460041756 100319475328460041756 No Department of Biochemistry, Payame Noor University of Tehran, Tehran, Iran Department of Biochemistry, Payame Noor University of Tehran, Tehran, Iran