en A Systematic Review on Main Chemical Constituents of <i>Papaver bracteatum</i> فارماكوگنوزی و فارماسيوتيكس Pharmacognosy & Pharmaceutics پژوهشی Research <div dir="ltr" style="text-align: justify;">Papaver bracteatum Lindly (Papaveraceae) is an endemic species of Iran which has economic importance in drug industries. The main alkaloid of the plant is thebaine which is used as a precursor of the semi-synthetic and synthetic compounds including codeine and naloxone, respectively. This systematic review focuses on main component of Papaver bracteatum and methods used to determine thebaine. All studies which assessed the potential effect of the whole plant or its extract on clinical or preclinical studies were reviewed. In addition, methods for determination of the main components, especially thebaine, which have been published from 1948 to March 2013, were included. Exclusion criteria were agricultural studies that did not assess. This study has listed alkaloids identified in P. bracteatum which reported since 1948 to 2013. Also, the biological activities of main compounds of Papaver bracteatum including thebaine, isothebaine, (-)-nuciferine have been reviewed. As thebaine has many medicinal and industrial values, determination methods of thebaine in P. bracteatum were summarized. The methods have being used for determination of thebaine include chromatographic (HPLC, GC and TLC) and non chromatographic methods. HPLC methods seem to be the best method from the angle of time consuming, cost and data accuracy and precision.</div> <div style="text-align: justify;">Papaver bracteatum Lindly (Papaveraceae) is an endemic species of Iran which has economic importance in drug industries. The main alkaloid of the plant is thebaine which is used as a precursor of the semi-synthetic and synthetic compounds including codeine and naloxone, respectively. This systematic review focuses on main component of Papaver bracteatum and methods used to determine thebaine. All studies which assessed the potential effect of the whole plant or its extract on clinical or preclinical studies were reviewed. In addition, methods for determination of the main components, especially thebaine, which have been published from 1948 to March 2013, were included. Exclusion criteria were agricultural studies that did not assess. This study has listed alkaloids identified in P. bracteatum which reported since 1948 to 2013. Also, the biological activities of main compounds of Papaver bracteatum including thebaine, isothebaine, (-)-nuciferine have been reviewed. As thebaine has many medicinal and industrial values, determination methods of thebaine in P. bracteatum were summarized. The methods have being used for determination of thebaine include chromatographic (HPLC, GC and TLC) and non chromatographic methods. HPLC methods seem to be the best method from the angle of time consuming, cost and data accuracy and precision.</div> ,Papaver bracteatum, Chemical constituents, Systematic review, Thebaine Papaver bracteatum, Chemical constituents, Systematic review, Thebaine 6 14 http://jmp.ir/browse.php?a_code=A-10-123-7&slc_lang=en&sid=1 M Soleymankhani M Soleymankhani 100319475328460041747 100319475328460041747 No Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran F Khalighi-Sigaroodi F Khalighi-Sigaroodi khalighi@imp.ac.ir 100319475328460041748 100319475328460041748 Yes Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran R Hajiaghaee R Hajiaghaee 100319475328460041749 100319475328460041749 No Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran H Naghdi Badi H Naghdi Badi 100319475328460041750 100319475328460041750 No Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran A Mehrafarin A Mehrafarin 100319475328460041751 100319475328460041751 No Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran M Ghorbani Nohooji M Ghorbani Nohooji 100319475328460041752 100319475328460041752 No Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran