en Effects of <i>Nigella sativa</i> L. Seed Oil in Type II Diabetic Patients: a Randomized, Double-Blind, Placebo - Controlled Clinical Trial فارماكولوژی و سم شناسی Pharmacology & Toxicology پژوهشی Research <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> <em>Nigella sativa</em> (<em>N. sativa</em>) seeds are used to treat diabetes mellitus in traditional medicine. Moreover, <em>N. sativa</em> oil has reduced the fasting blood glucose level in non-diabetic volunteers. <strong>Objective:</strong> The present study was undertaken to explore the possible anti-hyperglycemic effect of <em>N. sativa</em> oil in type II diabetic patients. <strong>Methods:</strong> A randomized clinical trial was conducted in 70 type II diabetic patients referring to Baqiyatallah Hospital. The subjects were enrolled into two groups of 35 each. One group received 2.5 ml <em>N. sativa</em> oil and the other group received similarly 2.5 ml mineral oil two times a day for three months. The fasting and 2 hour postprandial blood glucose, glycosylated hemoglobin (HbA1c), lipid profile, BMI (body mass index), liver and renal function test were determined at the baseline and after three months. <strong>Results: </strong>The blood levels of fasting and 2 hours postprandial glucose and HbA1c were significantly decreased in the <em>N. sativa</em> group compared with the placebo group at the end of the study. The BMI of the <em>N. sativa</em> group was decreased significantly from baseline. No side effects were reported. <strong>Conclusion: </strong><em>N. sativa</em> oil improves glycemic control in type II diabetic patients without any side effects.</div> <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> <em>Nigella sativa</em> (<em>N. sativa</em>) seeds are used to treat diabetes mellitus in traditional medicine. Moreover, <em>N. sativa</em> oil has reduced the fasting blood glucose level in non-diabetic volunteers. <strong>Objective:</strong> The present study was undertaken to explore the possible anti-hyperglycemic effect of <em>N. sativa</em> oil in type II diabetic patients. <strong>Methods:</strong> A randomized clinical trial was conducted in 70 type II diabetic patients referring to Baqiyatallah Hospital. The subjects were enrolled into two groups of 35 each. One group received 2.5 ml <em>N. sativa</em> oil and the other group received similarly 2.5 ml mineral oil two times a day for three months. The fasting and 2 hour postprandial blood glucose, glycosylated hemoglobin (HbA1c), lipid profile, BMI (body mass index), liver and renal function test were determined at the baseline and after three months. <strong>Results: </strong>The blood levels of fasting and 2 hours postprandial glucose and HbA1c were significantly decreased in the <em>N. sativa</em> group compared with the placebo group at the end of the study. The BMI of the <em>N. sativa</em> group was decreased significantly from baseline. No side effects were reported. <strong>Conclusion: </strong><em>N. sativa</em> oil improves glycemic control in type II diabetic patients without any side effects.</div> Nigella sativa, Blood glucose, Diabetes, Traditional medicine Nigella sativa, Blood glucose, Diabetes, Traditional medicine 93 99 http://jmp.ir/browse.php?a_code=A-10-90-1&slc_lang=en&sid=1 MS Hosseini MS Hosseini 100319475328460042068 100319475328460042068 No Religion and Medicine Research Center, Baqiyatallah University of Medical Sciences Religion and Medicine Research Center, Baqiyatallah University of Medical Sciences SA Mirkarimi SA Mirkarimi 100319475328460042069 100319475328460042069 No Religion and Medicine Research Center, Baqiyatallah University of Medical Sciences Religion and Medicine Research Center, Baqiyatallah University of Medical Sciences M Amini M Amini 100319475328460042070 100319475328460042070 No Gastroentrology and Liver diseases Research Center, Baqiyatallah University of Medical Sciences Gastroentrology and Liver diseases Research Center, Baqiyatallah University of Medical Sciences R Mohtashami R Mohtashami 100319475328460042071 100319475328460042071 No Religion and Medicine Research Center, Baqiyatallah University of Medical Sciences Religion and Medicine Research Center, Baqiyatallah University of Medical Sciences S Kianbakht S Kianbakht 100319475328460042072 100319475328460042072 No 3- Pharmacology and applied Medicine Department of Medicinal Plant Research Center, Institute of Medicinal Plants, ACECR Pharmacology and applied Medicine Department of Medicinal Plant Research Center, Institute of Medicinal Plants, ACECR H Fallah Huseini H Fallah Huseini Huseini_fallah@yahoo.com 100319475328460042073 100319475328460042073 Yes Pharmacology and applied Medicine Department of Medicinal Plant Research Center, Institute of Medicinal Plants, ACECR Pharmacology and applied Medicine Department of Medicinal Plant Research Center, Institute of Medicinal Plants, ACECR