en Protective Effects of <i>Vaccinium arctostaphylos</i> L., <i>Berberis thunbergii</i> var. <i>atropurpurea</i> Chenault, <i>Elaeagnus angustifolia</i> L. and <i>Launaea acanthodes</i> (Boiss.) O. Kuntze against Indomethacin-Induced Gastric Ulcers in Rats فارماكولوژی و سم شناسی Pharmacology & Toxicology پژوهشی Research <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Data suggest that <em>V. arctostaphylos</em>, <em>B. thunbergii</em> var. <em>atropurpurea</em>, <em>E. angustifolia</em> and <em>L. acanthodes</em> may prevent gastric ulcers induced by Non-steroidal anti-inflammatory drugs (NSAIDs). <strong>Objective:</strong> To explore the ulcer-protective potential of these plants in indomethacin-induced gastric ulcers in rats. <strong>Methods:</strong> Saline, hydro-alcoholic extract of each plant (100, 400, 800 mg/kg) and omeprazole (30 mg/kg) were gavaged to the groups of animals for 4 consecutive days. Gastric ulcers were induced by the onetime gavage of indomethacin (30 mg/kg, p.o.). On the fifth day, each group was pretreated with physiological saline as control, extract (100, 400 or 800 mg/kg, p.o.) or omeprazole (30 mg/kg, p.o.) 30 min before the indomethacin administration. The animals were killed 6 h after the indomethacin administration. The stomachs were removed, opened along the greater curvature and washed in physiological saline. A person unaware of the type of treatment received by the animals examined the stomachs under a 3-fold magnifier. The areas and lengths of hemorrhagic lesions induced by indomethacin were measured using a dial caliper and the sum of measurements for each animal was referred to as the ulcer index. <strong>Results:</strong> All extracts reduced the ulcer index significantly compared to the control group (p < 0.05). <strong>Conclusion:</strong> These plants prevent NSAID-induced gastric ulcers in rats. The efficacy and potency of the gastro-protective effect of <em>L. acanthodes</em> appears to be higher than the other 3 plants.</div> <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Data suggest that <em>V. arctostaphylos</em>, <em>B. thunbergii</em> var. <em>atropurpurea</em>, <em>E. angustifolia</em> and <em>L. acanthodes</em> may prevent gastric ulcers induced by Non-steroidal anti-inflammatory drugs (NSAIDs). <strong>Objective:</strong> To explore the ulcer-protective potential of these plants in indomethacin-induced gastric ulcers in rats. <strong>Methods:</strong> Saline, hydro-alcoholic extract of each plant (100, 400, 800 mg/kg) and omeprazole (30 mg/kg) were gavaged to the groups of animals for 4 consecutive days. Gastric ulcers were induced by the onetime gavage of indomethacin (30 mg/kg, p.o.). On the fifth day, each group was pretreated with physiological saline as control, extract (100, 400 or 800 mg/kg, p.o.) or omeprazole (30 mg/kg, p.o.) 30 min before the indomethacin administration. The animals were killed 6 h after the indomethacin administration. The stomachs were removed, opened along the greater curvature and washed in physiological saline. A person unaware of the type of treatment received by the animals examined the stomachs under a 3-fold magnifier. The areas and lengths of hemorrhagic lesions induced by indomethacin were measured using a dial caliper and the sum of measurements for each animal was referred to as the ulcer index. <strong>Results:</strong> All extracts reduced the ulcer index significantly compared to the control group (p < 0.05). <strong>Conclusion:</strong> These plants prevent NSAID-induced gastric ulcers in rats. The efficacy and potency of the gastro-protective effect of <em>L. acanthodes</em> appears to be higher than the other 3 plants.</div> Anti-ulcer, Herbal, Medicine, Rat, Traditional Anti-ulcer, Herbal, Medicine, Rat, Traditional 62 69 http://jmp.ir/browse.php?a_code=A-10-71-2&slc_lang=en&sid=1 H Fallah Huseini H Fallah Huseini 100319475328460036648 100319475328460036648 No Pharmacology & Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR Pharmacology & Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR S Kianbakht S Kianbakht skianbakht@yahoo.com 100319475328460036649 100319475328460036649 Yes Pharmacology & Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR Pharmacology & Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR M Hoormand M Hoormand 100319475328460036650 100319475328460036650 No Pharmacology & Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR Pharmacology & Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR