en The Effect of Aerobic Training Combined and Green tea (<i>Camellia sinensis</i> L.) Extract Consumption on Blood Glucose and Lipid Profile in Streptozotocin Induced Diabetic Rats فارماكولوژی و سم شناسی Pharmacology & Toxicology پژوهشی Research <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Type 2 diabetes is a global health problem and a major cause of illness. Exercise, diet and medication are the three pillars in the treatment of type 2 diabetes. <strong>Objective:</strong> The aim of the present study was to investigate the effect of aerobic training combined with green tea hydroalcoholic extract consumption on blood glucose and lipid profile on diabetic rats. <strong>Methods:</strong> Diabetes was induced in 40 male Wistar rats by intraperitoneal injection of 50 ml/kg streptozocin. After two weeks the diabetic rats with fasting blood glucose of 150 to 300 mg/dl were divided into 4 groups of 10 rats each and named as: aerobic exercise, aerobic exercise with green tea, green tea, and control. Aerobic exercise was performed as running on Treadmill for 5 days a week daily for 30-90 minutes with Treadmill speed of 18 -24 meters per minute. Green tea extract (100 mg/kg) was gavages once a day for 5 weeks. At baseline and endpoint fasting blood glucose, cholesterol, HDL-c, LDL-c and triglyceride levels were determined in all groups. <strong>Results:</strong> Fasting blood glucose level decreased significantly in all groups but triglyceride and cholesterol decreased in aerobic exercise and aerobic exercise + green tea groups at end point compared with baseline and also compared with control group. Fasting blood LDL-c level significantly decreased and HDL-c level significantly increase, in aerobic exercise and aerobic exercise with green tea at end point compared with baseline and also compared with control and green tea group. <strong>Conclusion:</strong> Aerobic exercise favorably affects glucose and lipid profile and in combination with green tea it has synergistic effects.</div> <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Type 2 diabetes is a global health problem and a major cause of illness. Exercise, diet and medication are the three pillars in the treatment of type 2 diabetes. <strong>Objective:</strong> The aim of the present study was to investigate the effect of aerobic training combined with green tea hydroalcoholic extract consumption on blood glucose and lipid profile on diabetic rats. <strong>Methods:</strong> Diabetes was induced in 40 male Wistar rats by intraperitoneal injection of 50 ml/kg streptozocin. After two weeks the diabetic rats with fasting blood glucose of 150 to 300 mg/dl were divided into 4 groups of 10 rats each and named as: aerobic exercise, aerobic exercise with green tea, green tea, and control. Aerobic exercise was performed as running on Treadmill for 5 days a week daily for 30-90 minutes with Treadmill speed of 18 -24 meters per minute. Green tea extract (100 mg/kg) was gavages once a day for 5 weeks. At baseline and endpoint fasting blood glucose, cholesterol, HDL-c, LDL-c and triglyceride levels were determined in all groups. <strong>Results:</strong> Fasting blood glucose level decreased significantly in all groups but triglyceride and cholesterol decreased in aerobic exercise and aerobic exercise + green tea groups at end point compared with baseline and also compared with control group. Fasting blood LDL-c level significantly decreased and HDL-c level significantly increase, in aerobic exercise and aerobic exercise with green tea at end point compared with baseline and also compared with control and green tea group. <strong>Conclusion:</strong> Aerobic exercise favorably affects glucose and lipid profile and in combination with green tea it has synergistic effects.</div> Aerobic exercise, Green tea, Lipid profile, Glucose, Rat Aerobic exercise, Green tea, Lipid profile, Glucose, Rat 84 92 http://jmp.ir/browse.php?a_code=A-10-90-10&slc_lang=en&sid=1 F Hovanloo F Hovanloo 100319475328460036394 100319475328460036394 No Phisical Education and Sport Science College, Shahid Beheshti University, Tehran, Iran Phisical Education and Sport Science College, Shahid Beheshti University, Tehran, Iran Y Shahvali Koohshoori Y Shahvali Koohshoori 100319475328460036395 100319475328460036395 No Phisical Education and Sport Science College, Shahid Beheshti University, Tehran, Iran Phisical Education and Sport Science College, Shahid Beheshti University, Tehran, Iran M Teimoorian M Teimoorian 100319475328460036396 100319475328460036396 No Phisical Education and Sport Science College, Shahid Beheshti University, Tehran, Iran Phisical Education and Sport Science College, Shahid Beheshti University, Tehran, Iran M Saadati M Saadati 100319475328460036397 100319475328460036397 No Phisical Education and Sport Science College, Shahid Beheshti University, Tehran, Iran Phisical Education and Sport Science College, Shahid Beheshti University, Tehran, Iran H Fallah Huseini H Fallah Huseini h.fallah@acecr.ac.ir 100319475328460036398 100319475328460036398 Yes Pharmacology & Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Pharmacology & Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran