en Effect of <i>Rubia tinctorum</i> L. Extractson Carrageenan-Induced Paw Edema in Rats فارماكولوژی و سم شناسی Pharmacology & Toxicology پژوهشی Research <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Inflammation is a dynamic process that is elicited in response to various harmful stimulantsthat may threaten the well-being of the host. Herbs have been traditionally used as anti-inflammatory agents since very early times. <em>Rubia tinctorum</em> L. is one of these herbs that havebeen used for treating inflammatory diseases in Iranian traditional medicine. <strong>Objective:</strong> This study aims at considering anti-inflammatory effects of <em>R. tinctorum</em> and comparing its extracts in this property. <strong>Methods:</strong> The root of <em>Rubia tinctorum</em> (Rubiaceae) was collected from Yazd province, in the center of Iran. The root extracts of plant were studied for their anti-inflammatory activity by using carrageenan-induced hind paw edema in Wistarmale rats. Indomethacin and normal saline were used as positive and negative controls, respectively. Different concentrations of aqueous, ethanolic, and 50% aq. ethanolic extracts (600, 800, 1000 mg/kg) were given orally before carrageenan injection. The paw thickness was measured at 1, 3 and 5 hours after injection. <strong>Results:</strong> Both, aqueous and 50% eq. ethanolic extracts reduced paw edema at 600 and 800 mg/kg concentrations. Moreover, ethanolic extract showed significant effect only in1sthour after carrageenan injection. <strong>Conclusion:</strong> The results indicated that the aqueous extract were exhibited higher anti-inflammatory effect compared with other extracts. Accordingly, the potent anti-inflammatory effect of the root extracts is attributed to the polar compounds which are extracted in the water.</div> <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Inflammation is a dynamic process that is elicited in response to various harmful stimulantsthat may threaten the well-being of the host. Herbs have been traditionally used as anti-inflammatory agents since very early times. <em>Rubia tinctorum</em> L. is one of these herbs that havebeen used for treating inflammatory diseases in Iranian traditional medicine. <strong>Objective:</strong> This study aims at considering anti-inflammatory effects of <em>R. tinctorum</em> and comparing its extracts in this property. <strong>Methods:</strong> The root of <em>Rubia tinctorum</em> (Rubiaceae) was collected from Yazd province, in the center of Iran. The root extracts of plant were studied for their anti-inflammatory activity by using carrageenan-induced hind paw edema in Wistarmale rats. Indomethacin and normal saline were used as positive and negative controls, respectively. Different concentrations of aqueous, ethanolic, and 50% aq. ethanolic extracts (600, 800, 1000 mg/kg) were given orally before carrageenan injection. The paw thickness was measured at 1, 3 and 5 hours after injection. <strong>Results:</strong> Both, aqueous and 50% eq. ethanolic extracts reduced paw edema at 600 and 800 mg/kg concentrations. Moreover, ethanolic extract showed significant effect only in1sthour after carrageenan injection. <strong>Conclusion:</strong> The results indicated that the aqueous extract were exhibited higher anti-inflammatory effect compared with other extracts. Accordingly, the potent anti-inflammatory effect of the root extracts is attributed to the polar compounds which are extracted in the water.</div> ,Rubia tinctorum, Rubiaceae, Anti-inflammatory, Carrageenan, Paw edema Rubia tinctorum, Rubiaceae, Anti-inflammatory, Carrageenan, Paw edema 62 70 http://jmp.ir/browse.php?a_code=A-10-149-6&slc_lang=en&sid=1 M Sharifzadeh M Sharifzadeh 100319475328460041801 100319475328460041801 No Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran N Ebadi N Ebadi 100319475328460041802 100319475328460041802 No Department of Traditional Pharmacy, Faculty of Traditional Medicine andPersian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran Department of Traditional Pharmacy, Faculty of Traditional Medicine andPersian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran A Manayi A Manayi 100319475328460041803 100319475328460041803 No Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran M Kamalinejad M Kamalinejad 100319475328460041804 100319475328460041804 No Department of Pharmacognosy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran Department of Pharmacognosy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran H Rezaeizadeh H Rezaeizadeh 100319475328460041805 100319475328460041805 No Student Scientific Research Center, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Iran Student Scientific Research Center, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Iran M Mirabzadeh M Mirabzadeh 100319475328460041806 100319475328460041806 No Department of Traditional Pharmacy, Faculty of Traditional Medicine andPersian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran Department of Traditional Pharmacy, Faculty of Traditional Medicine andPersian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran B Bonakdar Yazdi B Bonakdar Yazdi 100319475328460041807 100319475328460041807 No Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran M Khanavi M Khanavi khanavim@tums.ac.ir 100319475328460041808 100319475328460041808 Yes Department of Traditional Pharmacy, Faculty of Traditional Medicine andPersian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran Department of Traditional Pharmacy, Faculty of Traditional Medicine andPersian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran