en Comparison of Super Critical Fluid Extraction and Hydrodistillation Methods on Lavander΄s Essential Oil Composition and Yield فارماكوگنوزی و فارماسيوتيكس Pharmacognosy & Pharmaceutics پژوهشی Research <p dir="ltr" style="text-align: justify;"><strong>Background:</strong> Lavender&rsquo;s essential oil is commonly used in aromatherapy and massage. Its major clinical benefits are on the central nervous system. Linalyl acetate and linalool are the most predominant chemical constituents in the essential oil of <i>Lavandula angustifolia</i>.</p> <p dir="ltr" style="text-align: justify;"><strong>Objective:</strong> Comparison of super critical fluid extraction (SCFE) and hydrodistillation (HD) methods on Lavander΄s essential oil composition and yield methods.</p> <p dir="ltr" style="text-align: justify;"><strong>Method:</strong> In this work we extracted essential oil of this plant with two different methods SCFE and HD and further analyzed by GC and GC-MS method.</p> <p dir="ltr" style="text-align: justify;"><strong>Results:</strong> seventeen compounds were identified in the oil which prepared by HD, the major components of them were j. pinene (35.9%) and lavandulyl acetate (14.1%). In the SCFE extracted sample, the most frequent components were linalyl acetate (73.5%) and lavandulyl acetate (7.5%).</p> <div dir="ltr" style="text-align: justify;"><strong>Conclusion:</strong> According to obvious difference in the composition of the essential oils prepared by two different methods (SCFE & HD), it seems that extraction method differ chemical composition of the oil and probably affects pharmacological properties.</div> <p dir="ltr" style="text-align: justify;"><strong>Background:</strong> Lavender&rsquo;s essential oil is commonly used in aromatherapy and massage. Its major clinical benefits are on the central nervous system. Linalyl acetate and linalool are the most predominant chemical constituents in the essential oil of <i>Lavandula angustifolia</i>.</p> <p dir="ltr" style="text-align: justify;"><strong>Objective:</strong> Comparison of super critical fluid extraction (SCFE) and hydrodistillation (HD) methods on Lavander΄s essential oil composition and yield methods.</p> <p dir="ltr" style="text-align: justify;"><strong>Method:</strong> In this work we extracted essential oil of this plant with two different methods SCFE and HD and further analyzed by GC and GC-MS method.</p> <p dir="ltr" style="text-align: justify;"><strong>Results:</strong> seventeen compounds were identified in the oil which prepared by HD, the major components of them were j. pinene (35.9%) and lavandulyl acetate (14.1%). In the SCFE extracted sample, the most frequent components were linalyl acetate (73.5%) and lavandulyl acetate (7.5%).</p> <div dir="ltr" style="text-align: justify;"><strong>Conclusion:</strong> According to obvious difference in the composition of the essential oils prepared by two different methods (SCFE & HD), it seems that extraction method differ chemical composition of the oil and probably affects pharmacological properties.</div> Lavender, Supercritical extraction, Hydrodistilation, Essential oil Lavender, Supercritical extraction, Hydrodistilation, Essential oil 63 68 http://jmp.ir/browse.php?a_code=A-10-241-7&slc_lang=en&sid=1 Sh Rezazadeh Sh Rezazadeh 100319475328460038856 100319475328460038856 No Pharmacognosy Department, Institute of Medicinal Plants, ACECR, Tehran Pharmacognosy Department, Institute of Medicinal Plants, ACECR, Tehran B. Z. B.F. Baha - aldini B. Z. B.F. Baha - aldini 100319475328460038857 100319475328460038857 No Pharmacology Department, School of Medicine, Shiraz University of Medical Sciences Pharmacology Department, School of Medicine, Shiraz University of Medical Sciences A Vatanara A Vatanara 100319475328460038858 100319475328460038858 No Pharmaceutics Department, School of Pharmacy, Medical Sciences /University of Tehran Pharmaceutics Department, School of Pharmacy, Medical Sciences /University of Tehran B Behbahani B Behbahani 100319475328460038859 100319475328460038859 No Pharmacology Department, School of Medicine, Shiraz University of Medical Sciences Pharmacology Department, School of Medicine, Shiraz University of Medical Sciences A Rouholamini Najafabadi A Rouholamini Najafabadi 100319475328460038860 100319475328460038860 No Pharmaceutics Department, School of Pharmacy, Medical Sciences /University of Tehran Pharmaceutics Department, School of Pharmacy, Medical Sciences /University of Tehran M Maleky-Doozzadeh M Maleky-Doozzadeh 100319475328460038861 100319475328460038861 No Pharmacognosy Department, Institute of Medicinal Plants, ACECR, Tehran M Yarigar-Ravesh M Yarigar-Ravesh 100319475328460038862 100319475328460038862 No Pharmacognosy Department, Institute of Medicinal Plants, ACECR, Tehran Pharmacognosy Department, Institute of Medicinal Plants, ACECR, Tehran M Pirali Hamedani M Pirali Hamedani mpirali@fdo.ir 100319475328460038863 100319475328460038863 Yes Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences and Food and Drug Laboratory Research Center, Tehran Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences and Food and Drug Laboratory Research Center, Tehran