en Evaluation Effects of Quercetin on Liver Apoptosis in Streptozotocin-induced Diabetic Rat فارماكولوژی و سم شناسی Pharmacology & Toxicology پژوهشی Research <p dir="ltr" style="text-align: justify;"><strong>Background:</strong> Quercetin is a strong antioxidant and long-term treatment of STZ-diabetic animals and it has been shown to reduce oxidative stress.</p> <p dir="ltr" style="text-align: justify;"><strong>Objective:</strong> Antioxidants have essential effect on spermatogenesis and sperm parameters. Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus.</p> <p dir="ltr" style="text-align: justify;"><strong>Methods:</strong> Wistar male rat (n=40) were allocated into three groups, control group (n=10) and Quercetin (QR) group that received 15mg/kg (IP) QR, (n=10), and Diabetic group that received 55mg/kg (IP) streptozotocin (STZ) (n=20) which was subdivided to two groups of 10 STZ group and treatment group. Treatment group received 55mg/kg (IP) STZ plus15mg/kg QR, daily for,4 weeks, respectively however, the control group just received an equal volume of distilled water daily(IP) . Diabetes was induced by a single (IP) injection of streptozotocin (55mg/kg) .Animals were kept in standard condition. In 28day after inducing diabetic 5cc blood were collected for TAC,MDA and Ox-LDL levels and Liver tissues of Rat in whole groups were removed then prepared for Apoptosis analysis by Tunel method.</p> <p dir="ltr" style="text-align: justify;"><strong>Results:</strong> Apoptotic cells significantly decreased in group that has received 15mg/kg (IP) Quercetin (P<0.05) in comparison to experimental groups (P<0.05).</p> <div dir="ltr" style="text-align: justify;"><strong>Conclusion:</strong> Since in our study 15mg/kg (IP) Quercetin have significantly Preventive effect on liver cells damages by reducing number of Apoptotic cells in liver, so it seems that using it can be effective for treatment in Diabetic Rat.</div> <p dir="ltr" style="text-align: justify;"><strong>Background:</strong> Quercetin is a strong antioxidant and long-term treatment of STZ-diabetic animals and it has been shown to reduce oxidative stress.</p> <p dir="ltr" style="text-align: justify;"><strong>Objective:</strong> Antioxidants have essential effect on spermatogenesis and sperm parameters. Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus.</p> <p dir="ltr" style="text-align: justify;"><strong>Methods:</strong> Wistar male rat (n=40) were allocated into three groups, control group (n=10) and Quercetin (QR) group that received 15mg/kg (IP) QR, (n=10), and Diabetic group that received 55mg/kg (IP) streptozotocin (STZ) (n=20) which was subdivided to two groups of 10 STZ group and treatment group. Treatment group received 55mg/kg (IP) STZ plus15mg/kg QR, daily for,4 weeks, respectively however, the control group just received an equal volume of distilled water daily(IP) . Diabetes was induced by a single (IP) injection of streptozotocin (55mg/kg) .Animals were kept in standard condition. In 28day after inducing diabetic 5cc blood were collected for TAC,MDA and Ox-LDL levels and Liver tissues of Rat in whole groups were removed then prepared for Apoptosis analysis by Tunel method.</p> <p dir="ltr" style="text-align: justify;"><strong>Results:</strong> Apoptotic cells significantly decreased in group that has received 15mg/kg (IP) Quercetin (P<0.05) in comparison to experimental groups (P<0.05).</p> <div dir="ltr" style="text-align: justify;"><strong>Conclusion:</strong> Since in our study 15mg/kg (IP) Quercetin have significantly Preventive effect on liver cells damages by reducing number of Apoptotic cells in liver, so it seems that using it can be effective for treatment in Diabetic Rat.</div> Apoptosis, Diabetic, Quercetin, Streptozotocin, Liver, Rat Apoptosis, Diabetic, Quercetin, Streptozotocin, Liver, Rat 70 78 http://jmp.ir/browse.php?a_code=A-10-176-11&slc_lang=en&sid=1 AA Khaki AA Khaki 100319475328460038548 100319475328460038548 Yes Department of Anatomy, Islamic Azad University, Branch Bonab, Iran Department of Anatomy, Islamic Azad University, Branch Bonab, Iran A Khaki A Khaki 100319475328460038549 100319475328460038549 No Department of Veterinary Pathology Islamic Azad University, Branch Tabriz, Tabriz, Iran Department of Veterinary Pathology Islamic Azad University, Branch Tabriz, Tabriz, Iran M Nouri M Nouri 100319475328460038550 100319475328460038550 No Department of Biochemistry, Tabriz Medical Sciences University, Tabriz, Iran Department of Biochemistry, Tabriz Medical Sciences University, Tabriz, Iran HR Ahmadi-Ashtiani HR Ahmadi-Ashtiani 100319475328460038551 100319475328460038551 No Biochemistry & Nutrition Department of Zanjan Medical University, Clinical Biochemistry, Tarbiat-e-Modarres University, School of Medical Science, Department of Clinical Biochemistry, Tehran, Iran Biochemistry & Nutrition Department of Zanjan Medical University, Clinical Biochemistry, Tarbiat-e-Modarres University, School of Medical Science, Department of Clinical Biochemistry, Tehran, Iran H Rastegar H Rastegar 100319475328460038552 100319475328460038552 No Ministry of Health and Medical Education, Food & drug laboratory Research Center, FDLRC, Tehran, Iran Ministry of Health and Medical Education, Food & drug laboratory Research Center, FDLRC, Tehran, Iran F Fathiazad F Fathiazad 100319475328460038553 100319475328460038553 No Department of Pharmacognosy. Tabriz Medical Sciences University, Tabriz, Iran Department of Pharmacognosy. Tabriz Medical Sciences University, Tabriz, Iran M Ghanbari M Ghanbari 100319475328460038554 100319475328460038554 No Medical student, Tabriz Medical Sciences University Medical student, Tabriz Medical Sciences University