en Compartments of Quercetin & <i>Allium cepa</i> (Onion) on Blood Glucose in Diabetic Rats فارماكولوژی و سم شناسی Pharmacology & Toxicology پژوهشی Research <div dir="ltr" style="text-align: justify;"> <p style="text-align: justify;"><strong>Background:</strong> The major concern in diabetes is increased oxidative stress. Maintaining a balance between reactive oxygen species (ROS) and antioxidants is a major mechanism in preventing damage from oxidative stress. Quercetin (QR) is a well-known flavonoid and a strong antioxidant derived from the onion, <i>Allium cepa</i>, and it has been shown to reduce oxidative stress in the long-term treatment of streptozotocin (STZ)-induced diabetes in animals.</p> <p style="text-align: justify;"><strong>Objective:</strong> We aimed to study on beneficial effects of QR & <i>Allium cepa</i> on regulation of blood glucose in diabetic model.</p> <p style="text-align: justify;"><strong>Methods:</strong> Seventy male 8-week-old Wistar albino rats weighing 250 &plusmn; 10 g were obtained, the rats were divided into seven groups comprising ten animals in each group. Diabetes induced with single intraperitoneal injection of STZ. Diabetic rats treated with quercetin (15mg/kg/day, started 48 hours after STZ injection) and <i>Allium cepa</i> juice (2cc/rat/day, started 48 hours after STZ injection). After 28 days treatment, analysis on blood glucose and insulin was done.</p> <p style="text-align: justify;"><strong>Results:</strong> The mean TAC showed a significant increase (p < 0.05) in the QR compared to the control, STZ and STZ + QR groups. Both QR and onion Juice had significant effect in lowering blood glucose (355.3 &plusmn; 104 mg/dl and 353.4 &plusmn; 103 mg/dl respectively) (p<0.05) in STZ induced diabetic animals. Both QR and onion juice had lowering effect in Serum insulin in healthy animals and significant increasing effect on serum insulin level in diabetic animals.</p> <div style="text-align: justify;"><strong>Conclusions:</strong><i>&nbsp;</i>Both QR and onion juice had good effect in modifying diabetes related biochemical parameters and they are recommended to be studied more in order to being used in the therapy.</div> </div> <p style="text-align: justify;"><strong>Background:</strong> The major concern in diabetes is increased oxidative stress. Maintaining a balance between reactive oxygen species (ROS) and antioxidants is a major mechanism in preventing damage from oxidative stress. Quercetin (QR) is a well-known flavonoid and a strong antioxidant derived from the onion, <i>Allium cepa</i>, and it has been shown to reduce oxidative stress in the long-term treatment of streptozotocin (STZ)-induced diabetes in animals.</p> <p style="text-align: justify;"><strong>Objective:</strong> We aimed to study on beneficial effects of QR & <i>Allium cepa</i> on regulation of blood glucose in diabetic model.</p> <p style="text-align: justify;"><strong>Methods:</strong> Seventy male 8-week-old Wistar albino rats weighing 250 &plusmn; 10 g were obtained, the rats were divided into seven groups comprising ten animals in each group. Diabetes induced with single intraperitoneal injection of STZ. Diabetic rats treated with quercetin (15mg/kg/day, started 48 hours after STZ injection) and <i>Allium cepa</i> juice (2cc/rat/day, started 48 hours after STZ injection). After 28 days treatment, analysis on blood glucose and insulin was done.</p> <p style="text-align: justify;"><strong>Results:</strong> The mean TAC showed a significant increase (p < 0.05) in the QR compared to the control, STZ and STZ + QR groups. Both QR and onion Juice had significant effect in lowering blood glucose (355.3 &plusmn; 104 mg/dl and 353.4 &plusmn; 103 mg/dl respectively) (p<0.05) in STZ induced diabetic animals. Both QR and onion juice had lowering effect in Serum insulin in healthy animals and significant increasing effect on serum insulin level in diabetic animals.</p> <div style="text-align: justify;"><strong>Conclusions:</strong><i>&nbsp;</i>Both QR and onion juice had good effect in modifying diabetes related biochemical parameters and they are recommended to be studied more in order to being used in the therapy.</div> Quercetin, Onion, Diabetes, Rat Quercetin, Onion, Diabetes, Rat 107 112 http://jmp.ir/browse.php?a_code=A-10-176-9&slc_lang=en&sid=1 A Khaki آرش خاکی arashkhaki@yahoo.com 100319475328460038144 100319475328460038144 Yes Department of Veterinary Pathology, Islamic Azad University, Tabriz Branch, Tabriz Department of Veterinary Pathology, Islamic Azad University, Tabriz Branch, Tabriz F Fathiazad فتحی زاد 100319475328460038145 100319475328460038145 No Department of Pharmacognosy Tabriz Medical University, Tabriz Department of Pharmacognosy Tabriz Medical University, Tabriz HR Ahmadi - Ashtiani حمیدرضا احمدی آشتیانی 100319475328460038146 100319475328460038146 No Department of Clinical Biochemistry, School of Medical Science, Tarbiat-e-Modarres University, Tehran, Iran & Biochemistry and Nutrition Department of Zanjan University of Medical Sciences, Zanjan, Institute of Medicinal Plants, ACECR, Tehran Department of Clinical Biochemistry, School of Medical Science, Tarbiat-e-Modarres University, Tehran, Iran & Biochemistry and Nutrition Department of Zanjan University of Medical Sciences, Zanjan, Institute of Medicinal Plants, ACECR, Tehran Sh Rezazadeh شمسعلی رضازاده 100319475328460038147 100319475328460038147 No Institute of Medicinal Plants, ACECR, Tehran Institute of Medicinal Plants, ACECR, Tehran H Rastegar حسین رستگار 100319475328460038148 100319475328460038148 No Ministry of Health and Medical Education, Food & Drug Laboratory Research Center, Tehran Ministry of Health and Medical Education, Food & Drug Laboratory Research Center, Tehran AM Imani ایمانی 100319475328460038149 100319475328460038149 No Department of Veterinary Pathology, Islamic Azad University, Tabriz Branch, Tabriz Department of Veterinary Pathology, Islamic Azad University, Tabriz Branch, Tabriz